Normandie Université

Use of cardiac magnetic resonance imaging after hospitalization for acute heart failure: insights from the French nationwide OFICA-2 cohort

Abstract Background Cardiac magnetic resonance (CMR) has a central role in the management of patients with acute heart failure (AHF), but timely access remains heterogeneous. We investigated real-world CMR use in patients hospitalized for AHF and its associations with demographic...

Aliphatic Diazirines Synthesis Mediated by Mild N -Chlorosuccinimide Oxidation

Abstract Diazirines have been known for decades as effective photoreactive moieties, with valuable applications in chemoproteomics. In recent years, they have received increasing interest in synthetic chemistry. Until recently, their access required a multistep process, which may...

Oxidative Fluorination of β-Ketoamides: Guanidinium Iodides as Iodoarene Alternatives

Abstract A guanidinium iodide-catalyzed oxidative fluorination of β-ketoamides enables umpolung α-fluorination, replacing iodoarenes with a simple iodide source. Using HF·pyridine as the fluoride source and mCPBA as the oxidant in dichloroethane, quaternary α-fluoro-β-ketoamides...

Tracking Base Note Persistence in Fragrances by Time‐Resolved Analysis: Revealing Ingredient Contributions

ABSTRACT The persistence of fragrance raw materials on substrates is a key parameter in fine perfumery. However, the analytical investigation of fragrance longevity remains challenging, particularly for base‐note ingredients characterized by low volatility and high substantivity....

Targeting Both Oncogenic Signaling and Dependence Receptor Function is Required to Fully Suppress MET Exon 14 Skipping-Driven tumorigenesis

Abstract Receptor tyrosine kinases (RTKs) classically function as oncogenic drivers that promote survival and proliferation upon ligand binding. A subset of RTKs can also function as dependence receptors, inducing apoptosis in the absence of their ligands. Genetic alterations tha...

Mechanistic insights into Nrf2- and PARP1-mediated radioresistance of glioblastoma stem cells under photon, proton, and carbon ion irradiation: An in vitro study

Glioblastoma multiforme (GBM) exhibits strong resistance to radiotherapy, partly driven by glioblastoma stem-like cells (GSCs) with enhanced redox homeostasis and DNA repair capacity. This study evaluated whether targeting Nrf2-mediated antioxidant signaling and PARP1-dependent D...

Hippocampal volume changes in astronauts and bilateral vestibulopathy patients

Abstract The hippocampus is a particularly plastic and vulnerable brain structure. Given the modulatory role of the vestibular system on hippocampal function, we hypothesized that altered vestibular stimulation associated with prolonged spaceflight could lead to similar hippocamp...

Evaluation of Disease Severity Using CSF Biomarkers in Patients With Probable Cerebral Amyloid Angiopathy

Cerebral amyloid angiopathy (CAA) is currently diagnosed using MRI-based Boston criteria. However, imaging markers represent downstream consequences of vascular injury and may not fully reflect disease severity. CSF biomarkers, particularly β-amyloid 1–42 (Aβ42) and β-amyloid 1–4...

Synergistic Grain Boundary and Phonon Engineering Enables Ultrahigh Thermoelectric Performance in Mg 3 (Sb, Bi) 2 ‐Based Materials

ABSTRACT Thermoelectric Mg 3 (Sb, Bi) 2 has emerged as a rising star in virtue of its promising thermoelectric performance and abundant constituent elements. However, its practical application is hindered by challenges in synthesis and the strong coupling between electrical and t...

New mechanistic insights into the widely used LiPO2F2 additive enabled by ultra-high-resolution FTICR-MS

Understanding how electrolyte additives influence the formation and evolution of the solid electrolyte interphase (SEI) is essential for improving the durability of lithium‑ion batteries. In this work, we investigate the role of lithium difluorophosphate (LiPO2F2, LiDFP) in 1 M L...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Neutron elastic scattering at $$\varvec{30.8}$$ MeV on $$\varvec{^{\text {nat}}\textrm{Ce}}$$

Abstract Elastic scattering of fast neutrons at an incident energy of 30.8 MeV on a natural cerium target was measured during an experiment conducted at the Neutrons For Science facility at GANIL-SPIRAL2. This is the first measurement on cerium using incident neutron energy above...

Development of antibacterial wipes coated with nanofibers made from nisin and polyvinyl alcohol

Nosocomial infections caused by Staphylococcus aureus ( S. aureus ), a major pathogen that colonizes human skin, are a significant cause of morbidity and mortality. Effective management of S. aureus is essential, especially given the rising threat of antibiotic resistance. Innova...

A Lifestyle Behavior Score Predicting Cardiovascular and Other Causes of Death in a Cohort of Middle-Aged Men Followed up Until Extinction

Objective: To create and test in a population study a behavior score, using as far as possible, procedures based on the a posteriori approach. Material and Methods: Data from the Italian Rural Areas (IRAs) of the Seven Countries Study of Cardiovascular Diseases (SCS), comprising...

Melanocortin Receptor Signaling Modulates Anti-Obesity and Glucose Tolerance Effects of Hafnia alvei 4597 Probiotic Strain in Mice

The present study aimed to elucidate whether the metabolic effects of the probiotic bacterium Hafnia alvei 4597 depend on melanocortin receptor (MCR) signaling. The response to a 3-week intragastric treatment with the H. alvei bacterial suspension or total protein extract was com...