Ningxia Medical University

Infrapopliteal runoff status predicts mid-term outcomes after endovascular popliteal artery aneurysm repair

This study aimed to evaluate mid-term outcomes after endovascular repair (EPAR) for popliteal artery aneurysms (PAAs), with a specific focus on identifying prognostic factors for adverse events after EPAR, particularly the impact of infrapopliteal runoff status. Open surgical rep...

Serum amyloid A on postoperative day 3 for early prediction of deep surgical site infection after degenerative spine surgery

Deep surgical site infection (dSSI) is a serious complication after degenerative spine surgery, and early postoperative risk identification remains challenging. This prospective single-center cohort study serially measured C-reactive protein (CRP), procalcitonin (PCT), and serum...

l-rhamnose suppresses triple-negative breast cancer via GSTM5-mediated ferroptosis

Triple-negative breast cancer lacks effective targeted therapies, necessitating novel treatment approaches.To evaluate the antitumor efficacy and molecular mechanisms of l -rhamnose in TNBC. We employed an integrated approach combining in vitro cell-based assays and in vivo xenog...

Sexual health as an overlooked dimension of holistic recovery after adult spine surgery: an evidence-informed narrative review

Abstract Background Sexual health is a meaningful but under-recognized dimension of recovery after spine surgery. Pain, neurological impairment, mobility, body image, psychological distress, relationship context, and procedure-specific injury may all affect postoperative sexual w...

Multidimensional analysis of pulmonary blastoma: clinical, bibliometric and bioinformatic insights

Abstract Objective Pulmonary blastoma (PB) is a rare primary lung tumor, accounting for less than 0.5% of all lung cancers. Its epidemiological and clinical characteristics remain unclear, and the molecular pathogenesis had not been fully elucidated, which poses challenges to sta...

Seminiferous Tubules‐Targeted Resveratrol Carbon Dots With Sertoli Cell Biomimetic Vesicles Fusion for Improving Spermatogenesis of Cryptorchidism

ABSTRACT Impaired blood‐testis barrier (BTB) integrity, induced by oxidative stress, is one of the primary factors leading to spermatogenic disorders in cryptorchidism. Therefore, the targeted elimination of testicular oxidative stress and repair of the BTB are promising strategi...

EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy

Purpose EIF1, an RNA-binding protein implicated in multiple diseases, remains poorly characterized in diabetic retinopathy (DR). This study therefore investigated EIF1 expression and function in an in vitro model of DR pathogenesis. Methods Human retinal pigment epithelial cells...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

UBE2S Promotes KIRC Progression by Regulating CDC20 Expression and Suppressing FDX1‐Mediated Cuproptosis, While Promoting M2 Macrophage Polarization

ABSTRACT This study aims to investigate the biological function, molecular mechanisms, and impact on the tumor microenvironment of the ubiquitin‐conjugating enzyme E2S (UBE2S) in the progression of kidney renal clear cell carcinoma (KIRC). Based on the TCGA and GEPIA databases, t...

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re-epithelial...

Paulownin: a promising agent In the fight against the invasion and immune escape in triple-negative breast cancer

Background Breast cancer is the most prevalent malignancy among females. Paulownin has anti-tumor properties and immune-modulating activities in various cancers; however, its effects on breast cancer remain inadequately understood.Aims This study aimed to elucidate the impact of...

Study on the role and mechanism of CIH-activated ferroptosis in secondary cognitive impairment due to OSAHS

Objective This study investigates whether chronic intermittent hypoxia (CIH) induces cognitive deficits through IL-6/hepcidin-mediated ferroptosis in patients and animal models with obstructive sleep apnea-hypopnea syndrome (OSAHS). Clinical and animal research demonstrates that...

Prohibitin 1 orchestrates mitochondrial-ER crosstalk via the VDAC1-GRP75-IP3R axis to drive malignancy in gastric cancer

<title>Abstract</title> <bold>Background</bold>: Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), serving as critical hubs for mitochondrial- ER interactions, play a pivotal role in cancer progression. Prohibitin 1 (PHB1), an inner mitochondrial membrane prote...

Preparation of a new fixed-combination carteolol-netarsudil ophthalmic solution via one-pot pH-adjusting solubilization strategy for glaucoma treatment

Currently, the commercial fixed-combination of two agents is facing several clinical challenges, including suboptimal intraocular pressure (IOP) reduction, which requires multiple daily administrations, compromised bioavailability due to rapid tear film clearance and nasolacrimal...

A retrospective comparative study of chronic subdural hematoma in patients with or without decreased level of consciousness

Abstract Background In this retrospective cross-sectional study, we aimed to investigate the effects of preoperative decreased level of consciousness (DOC) on 6-month outcome and the risk factors that compromised the consciousness at admission in patients with chronic subdural he...

Translational insights and clinical challenges of targeting cancer stem cells

Abstract Cancer stem cells (CSCs) are tumor cell subsets with self-renewal, multilineage differentiation, and tumor-initiating capacity that sustain cancer initiation, progression, metastasis, and relapse. Targeting CSCs therefore represents a promising route to improve the durab...

Latent Profiles of Post-Stroke Fatigue and Their Association with Anxiety, Depression, and Sleep in Patients with First-Ever Stroke: A Cross-Sectional Study

Objectives: This study aimed to identify latent profiles of post-stroke fatigue (PSF) and examined their associations with anxiety symptoms, depressive symptoms, and sleep quality among first-ever stroke survivors. Methods: From December 2023 to May 2024, participants were recrui...

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Abstract Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape...