Ningxia Medical University

Preoperative aggregate index of systemic inflammation and cause-specific 1-year mortality after surgery for geriatric intertrochanteric fracture

Older adults undergoing intertrochanteric-fracture surgery have high 1-year mortality. Routine preoperative complete blood count indices may provide readily available prognostic information before surgery. This prospective single-center cohort enrolled consecutive patients aged ≥...

How medical students experience disease-related information processing when a family member has cancer: a qualitative study

Communication of disease-related information in cancer care involves not only patients but also family members. In the Chinese family context, family members are often involved in obtaining, communicating, and processing illness-related information. However, little is known about...

Ligand-Dependent Affinity but State-Dominated Efficacy in Structure-Based GPCR Pharmacology Prediction

Abstract High accuracy in structure-based prediction of G protein-coupled receptor (GPCR) efficacy may reflect the receptor state rather than ligand-specific information. We addressed these information sources using state rules, ligand-blind baselines, matched receptor-state cont...

Untangling the Molecular Mechanism of SpCas9 HNH Domain Checkpoint Activation: A Gear-and-Wedge Fitting Model

Abstract The CRISPR-associated endonuclease Streptococcus pyogenes Cas9 (SpCas9) facilitates site-specific DNA cleavage, with structural transition from the checkpoint state to the catalytic conformation representing a critical activation step. This transition involves an approxi...

Cell-resolved spatial mapping of antibody-drug conjugate targets in breast cancer

Background Antibody-drug conjugate (ADC) activity and target-dependent on-target/off-tumor toxicity depends in part on which cells express the target antigen, a feature that bulk assays cannot resolve. Methods We analyzed a publicly available whole-transcriptome CosMx breast tumo...

The Toxic Effects and Mechanism of Acetamiprid Exposure on Testicular Tissue: ALKBH5 Regulates m6A Modification to Affect PI3K-AKT-Mediated Apoptosis

(1) Background: Acetamiprid, a widely used neonicotinoid insecticide, has increasingly drawn people’s attention to its potential reproductive toxicity risks. Although existing studies have shown that exposure to acetamiprid can cause testicular damage, its underlying molecular me...

A Simple Platelet-Centered Coagulation–Inflammation Combined Score for Predicting In-Hospital Mortality in Sepsis

OBJECTIVE: Accurate mortality prediction in sepsis requires assessing coagulation and inflammatory disturbances, yet existing scores are complex or incompletely capture these interconnected processes. We developed and internally validated a simple score combining inflammatory and...

1D/3D CdS NRs/Zn-MOF S-scheme heterostructure for highly efficient photocatalytic hydrogen evolution

Finding extremely effective and robust photocatalysts is crucial to achieving solar-driven hydrogen evolution. This study successfully constructed CdS NRs/Zn-MOF S-scheme heterojunctions with a built-in electric field by physically blending one-dimensional CdS nanorods with three...

Immunogenic effects of a combined recombinant protein formulation based on Brucella Omp19, Omp2b, Omp31, and BP26

Brucellosis is a neglected zoonotic disease for which no approved human vaccine is currently available. For Brucella , a typical intracellular pathogen, the success of recombinant protein vaccine development largely depends on whether it can effectively induce immune responses wi...

Living environmental quality and incident depressive symptoms among middle-aged and older adults in China: a national longitudinal study

Depressive symptoms are common in mid-to-late adulthood in China. Evidence linking living environments to depression has often focused on single exposures, and prospective evidence on the association between an integrated measure of living environmental quality (LEQ) and subseque...

Effectiveness and implementation of task-sharing cognitive-behavioral interventions for perinatal mental health: Protocol for a systematic review and meta-analyses

Cognitive behavioural interventions (CBIs) delivered by nonspecialist providers (NSPs) offer a scalable strategy to address the global mental health workforce gap, enhancing access to evidence-based care for perinatal depression and anxiety. The objective of this systematic revie...

Non-volatile metabolomic differentiation of geographical origin and quality grade in pre-Qingming Xihu Longjing green tea using in-source fragment ion-assisted annotation

Xihu Longjing green tea (XHLJT) faces challenges in origin and grade authentication due to mislabeling and limited chemical interpretability of sensory evaluation. Here, an enhanced untargeted metabolomics workflow integrating in-source fragment ion (ISFI) identification was deve...

Dose-conditioned machine-learning prediction of a composite target sedation state in patients undergoing propofol-sedated gastrointestinal endoscopy

BACKGROUND: During propofol-sedated gastrointestinal endoscopy, adequate sedation must be achieved without compromising hemodynamic stability or oxygenation. We developed and temporally validated dose-conditioned machine-learning models to predict a composite target sedation stat...

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

ABSTRACT Diabetic Foot Ulcer (DFU), a severe chronic diabetes complication with low healing and high recurrence rates, is a major global health challenge. Overexpression of matrix metalloproteinase‐9 (MMP‐9) and the consequent MMP‐9/TIMP1 (tissue inhibitor of metalloproteinase 1)...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

Prenatal paraben exposure and neonatal birth outcomes: The modifying role of mid‑to‑late pregnancy weight gain rate

Parabens are ubiquitous endocrine-disrupting chemicals. However, the effects of paraben mixtures on neonatal growth and the modifying role of post‑blood‑collection gestational weight gain rate (GWG_after) remain unclear. This prospective cohort included 934 mother-infant pairs fr...

Shifting from Systemic Absorption to Local Interactions: The Bidirectional Role of Gut Microbiota in Curcumin’s Health Benefits

Curcumin, a natural polyphenol, has garnered considerable attention owing to the paradox between its low oral bioavailability and reported pharmacological effects. Traditional paradigms centered on systemic absorption and plasma exposure may not fully explain its broad actions in...

MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism

The molecular mechanisms governing mRNA accumulation during oocyte growth, essential for developmental competence, remain poorly understood. This study investigates the role of Matrin-3 (MATR3), a highly expressed RNA-binding protein in growing oocytes (GOs), using oocyte-specifi...

Integrated multi-omics analyses reveal the role of PAXX in colorectal cancer progression and the tumor immune microenvironment

Abstract PAXX is a DNA double-strand break repair factor involved in classical non-homologous end joining. Although elevated PAXX expression has been reported in colon cancer, its functional role and downstream mechanisms in colorectal cancer (CRC) remain incompletely defined. Th...

The ALDW classification for fetal insular morphology: gestational norms and screening utility

To observe the changes in fetal insular morphology with gestational age using the transverse thalamic view, and to preliminarily explore the value of this approach in cases with nervous system abnormalities. Pregnant women between 18 and 34 weeks of gestation who attended the Pek...