Ningbo University

Hepatic GPR110 plays a complex and context-dependent role in metabolic dysfunction-associated steatotic liver disease

Metabolically-dysfunction-associated steatotic liver disease (MASLD)—formerly known as nonalcoholic fatty liver disease (NAFLD) —is now the most common chronic liver disease worldwide, affecting more than 30% of the global population. Recent studies have documented seemingly cont...

Potential mediating role of triglycerides in the nonlinear association between body roundness index and MASLD in nondiabetic adults

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, with visceral adiposity and dyslipidemia as key drivers. The body roundness index (BRI) is a novel anthropometric marker of visceral adiposity. Still, its nonlin...

Nicotinamide adenine dinucleotide phosphate hydrogen oxidase 2 exacerbates abdominal aortic aneurysm formation by inducing oxidative stress through autophagy inhibition.

, primary mouse vascular smooth muscle cells (VSMCs) were randomly divided into Control, AngII, AngII+GSK2795039, AngII+rapamycin (autophagy agonist, RA), and AngII+GSK2795039+RA groups. EDU assay, cell scratch assay, and mRFP-GFP-LC3 detection were conducted. ROS was measured by...

Early-life high-dose omega-3 polyunsaturated fatty acid supplementation reduces risk of childhood asthma/wheezing: A meta-analysis of randomized controlled trials.

BACKGROUND AND OBJECTIVES: Asthma, a chronic inflammatory airway disease characterized by wheezing, imposes a substantial global health burden on children. Given the potential of early-life omega-3 polyunsaturated fatty acid (omega-3 PUFA) supplementation as an anti-inflammatory...