Nazarbayev University

From Chronology to Physiology: A Critical Translational Assessment of Artificial Intelligence for Precision Healthspan Measurement

Healthspan, the period of life free from major chronic disease and disability, is a central geroscience outcome, yet its prediction remains difficult due to its multidimensional and heterogeneous nature. In this review, we synthesize advances in artificial intelligence (AI) for p...

Adsorption and Photocatalytic Activity of Covalent Organic Frameworks for Environmental Remediation: A Review of Density Functional Theory Studies

The contamination of water resources by heavy metals, radionuclides, and organic pollutants demands efficient materials for water treatment. Covalent organic frameworks (COFs) are promising candidates owing to their tunable porosity and functionalizable frameworks. This review ex...

The Effects of Cognitive–Perceptual Style on the Multilevel Organization of Postural Control During Motor Imagery and Immersive Virtual Reality

Understanding the central nervous system responses to different threats of balance loss is instrumental for developments in behavioral neurophysiology and rehabilitation. Motor imagery (MI) and virtual reality (VR) are used to model postural threats. Cognitive–perceptual style, s...

Cdc42 in Tumor Hypoxia: Molecular Mechanisms of Cellular Adaptation

Tumor hypoxia is a hallmark of solid tumors that promotes aggressiveness and resistance to therapy. Within hypoxic tumors, hypoxia-inducible factor (HIF)-dependent transcriptional programs drive metabolic reprogramming, lactate accumulation, extracellular acidosis, angiogenesis,...

Chronic Ultrasound (‘Emotional’) Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention

Background: Growing evidence supports a bidirectional relationship between ‘emotional’ (psychological) stress and intestinal inflammation. ‘Emotional stress’, a form of stress that is triggered by negative information and experiences of non-physical nature, is an established risk...

Improved Existence Time for the Whitham Equation and a Whitham–Boussinesq System

Abstract. In this paper, we investigate the time of existence of the solutions to two full dispersion models derived from the water waves equations in the shallow water regime: the Whitham equation and a Whitham–Boussinesq system in dimensions one and two. The regime is character...

Long-Term Tuberculosis Mortality Trends in Kazakhstan, 1998–2024: Regional Inequalities, Associated Factors and Health System Reforms

Background: Tuberculosis (TB) mortality remains an important indicator of disease burden, health system performance, and progress toward global TB control targets. This study aimed to assess long-term trends in TB mortality in Kazakhstan from 1998 to 2024 and to examine regional...

Low-cost single-beam SONAR localization in AUVs: Systematic experiments with acoustic and optical perception

This work presents a low-cost acoustic sensing framework for underwater robot (UWR) localization and perception, using single-beam sonars (SBS) and an external forward-looking sonar (FLS) for confined environments in place of costlier Doppler velocity logs (DVL) and onboard imagi...

Escherichia coli -derived enterobactin is associated with delayed gut microbiome maturation in infants born to mothers with obesity

ABSTRACT Maternal obesity has been increasingly recognized as a factor influencing early-life microbiome development. However, its impact on the infant gut resistome and virulome remains insufficiently characterized. In this prospective longitudinal study, we investigated gut mic...

Next-Generation Pharmacotherapy for Uterine Leiomyomas: Combining Metformin and Ulipristal Acetate as Neoadjuvant and Adjuvant Interventions to Minimally Invasive Procedures

Uterine fibroids (leiomyomas) are the most common benign tumors of the myometrium in women of reproductive age. They are a major cause of heavy menstrual bleeding, pelvic pressure and pain, and reduced fertility in women of reproductive age. This scoping review aims to examine th...

Genetic Basis of Social Structure in the Pastoral Nomads of Central Eurasia

Abstract Although the social structure of Central Eurasian pastoral nomads has been described as fluid and ad hoc by historians and anthropologists, its potential genetic basis remains poorly understood. To evaluate whether kinship based social organization has biological foundat...

Concordance of next-generation sequencing and conventional microbiology for pathogen detection and antimicrobial resistance prediction in pneumonia

Abstract Delays in pathogen and antimicrobial resistance (AMR) profiling adversely affect patient outcomes. Next-generation sequencing (NGS) may complement conventional microbiology (CM), yet real-world value of NGS in pneumonia diagnosis remains unclear. We quantified concordanc...

UAV-based deep learning and spatial analysis for mapping coastal plastic debris distribution

Plastic waste accumulation is a major environmental challenge in enclosed and semi-enclosed coastal basins where restricted hydrodynamic exchange can promote long-term litter retention. This study assesses surface macroplastic litter along the Neftchala shoreline of the western C...

Inkjet Printing of MXene Gas Sensors for Agricultural Monitoring

Abstract Inkjet printing enables scalable fabrication of nanomaterial-based devices, but stable droplet formation and reproducible deposition remain challenging for emerging nanosheet inks. In this work, we develop a model-guided inkjet printing framework that monitors and optimi...

Institutional trust in authoritarian regimes: evidence from Central Asia

Authoritarian regimes must cultivate forms of political legitimacy that compensate for the absence of competitive electoral accountability. Institutional trust is a central component of this legitimacy, shaping citizen compliance, regime support, and political stability. This art...

Evidentiality at the crossroads of temporality and modality in Kazakh: a fieldwork based study

Abstract This paper investigates the interface of evidentiality with tense, aspect, and modality in Kazakh. Recent fieldwork data from several regions of Kazakhstan reveal that non-firsthand inferential and firsthand direct perceptive evidentials are gradually being supplanted by...

The Role of TiO2 Powder Concentration in Spin-Coated WO3 Photoanodes

Abstract Photoactive tungsten oxide-based coatings were fabricated via a liquid-phase spin-coating method, with the addition of commercial TiO2 powder to make a composite. TiO2-added WO3 thin-film photoanodes (WO3–TiO2 composite) were investigated to identify the optimal concentr...

Plant-Derived Dipeptidyl Peptidase-4 Inhibitors in Cardiometabolic Disorders: A Critical Review of Natural Scaffolds and Experimental Evidence

Cardiometabolic disorders, including obesity, insulin resistance and type 2 diabetes mellitus, remain major biomedical problems closely linked to vascular complications. Dipeptidyl peptidase-4 (DPP-4) is a clinically validated therapeutic target because inhibition of this enzyme...

Discovery of a Compact Hub-Filament System in G286.21+0.17 with JWST and ALMA: Insights into Protocluster Formation and Competitive Accretion

Abstract We present a multi-wavelength study of the massive protocluster G286.21+0.17 (G286) using JWST near-infrared (NIR) imaging and ALMA H13CO+(1–0) observations. The JWST images uncover a compact (∼0.5 pc) hub-filament system (HFS), comprising a dense central hub connected b...

Integrative analysis of lncRNA-miRNA-mRNA expression profiles in esophageal squamous cell carcinoma tissues

Esophageal cancer represent a major global health concern. Esophageal squamous cell carcinoma (ESCC) is the most prevalent histological subtype and exhibits pronounced population-specific variation in incidence. Unfortunately, the main cause of this geographical difference in dis...