National Taiwan University

Hepatocellular Carcinoma With JAK1 Mutations Harbors Distinct Histologic Features and Specific Mutational Hotspots in an Asian Cohort

The pathogenesis and clinicopathological features of hepatocellular carcinoma (HCC) harboring JAK1 mutation have not been reported. Sixty inflammatory hepatocellular adenoma-like HCCs (IHA-like HCCs) and 16 IHAs were analyzed using targeted next-generation sequencing. Nearly all...

Developing deep-learning models guided by semantics to colorize historical grayscale aerial imagery for land-cover classification

High-resolution historical aerial imagery is valuable for analyzing long-term land-cover and environmental change, but most deep-learning methods rely on multispectral or color data and cannot fully use grayscale archives. We developed a semantically guided framework that uses Op...

Synoptic and large‐scale drivers of extreme precipitation events in the Himalayas

Abstract Extreme precipitation events (EPEs) in the Western Himalayas (WH) have significant cross‐sector impacts, yet understanding of their seasonal characteristics and synoptic drivers remains inadequate. This study presents an analysis of EPEs across the full annual cycle of t...

Total Syntheses and Structural Reassignment of Ugonin T and Neougonin B: Anti-inflammatory Flavonoids Related to Helminthostachys zeylanica

Abstract This study reports the first total syntheses of the naturally occurring flavonoids ugonin C (1), ugonin F (2), and, based on the originally proposed structures, compounds 3 and 4 (corresponding to the structures first assigned to ugonin T and neougonin B, respectively),...

Interface Modulation of rGO/Bi 0 /BiOCl Enables Efficient Electron Utilization for CO 2 Photoreduction

ABSTRACT Engineering interfacial electronic structure is critical for enhanced charge utilization and product selectivity in photocatalytic CO 2 reduction toward multi‐electron hydrocarbon products. Herein, we report a one‐step glycerol‐assisted solvothermal strategy to construct...

Robust valley-polarized excitonic Mott states and doublons enabled by stacking-controlled moiré geometry

Atomically-thin moiré superlattices offer a platform for interacting bosons, where strong onsite repulsion $${U}_{{{\rm{xx}}}}$$ suppresses double occupancy and supports excitonic Mott states at unit filling. However, moiré confinement also enhances phonon- and disorder-assisted...

Association Between Unenhanced CT Features and Perioperative Outcomes in Bronchogenic Cyst Resection

Background: Reliable predictors of perioperative risk beyond symptomatology in bronchogenic cyst (BC) resection are lacking. We aimed to compare perioperative outcomes across different imaging features to identify perioperative risk factors. Methods: We conducted a retrospective...

Efficient power generation near room temperature in earth-abundant thermoelectric tin sulfide via lattice ordering

The inefficient carrier transport of earth-abundant tin sulfide (SnS), arising from its intrinsically low crystal symmetry, limits its thermoelectric performance at low temperatures. Here, the substitutional Ag+ doping modifies the Na-doped SnS crystal structure by reinforcing la...

Comparative outcomes of Bernese periacetabular osteotomy in adolescents, young adults, and middle-aged adults

Aims: Bernese periacetabular osteotomy (PAO) is a well-established procedure for symptomatic hip dysplasia in adolescents and young adults. Its application in middle-aged patients remains debated due to concerns regarding complications and uncertain outcomes. This study evaluated...

Fluorescent Advanced Glycation End Products and Their Implications in Diabetes Mellitus

ABSTRACT Elevated blood glucose levels are a key contributor to clinical pathologies of diabetes. Prolonged hyperglycemia accelerates the Maillard reaction in tissues and results in the physiological production of advanced glycation end products (AGEs). AGEs promote biochemical p...

Age-dependent performance of conventional trauma scores in older trauma patients: A retrospective trauma registry study

Population aging has increased the burden of trauma among older adults. Accurate risk stratification remains challenging because age-related physiological vulnerability may reduce the predictive accuracy of conventional trauma scoring systems. Evidence regarding the clinical util...

The Role of Convection–Circulation Coupling in Abrupt South Asian Monsoon Onset: Insights From SP‐CAM

Abstract This study investigates the effects of convection‐circulation coupling on the onset of the South Asian monsoon from a sectorial zonal‐mean perspective, using the Super‐parameterized Community Atmospheric Model (SP‐CAM), which couples Community Earth System Model version...

The effects of repetitive transcranial magnetic stimulation on executive functions in healthy and at-risk older adults: a systematic review and meta-analysis

Cognitive flexibility, inhibitory control, and working memory are core executive functions and early vulnerable cognitive domains across the continuum from healthy aging to mild cognitive impairment, highlighting the need for preventive interventions before substantial neurodegen...

Young minds in distress: Exploring the global rise in youth mental health diagnoses

Adolescence represents a critical neurobiological period marked by a developmental “mismatch” between early-maturing limbic systems and the later-maturing prefrontal cortex, conferring heightened vulnerability to the onset of psychiatric disorders. This review synthesizes global...

Linking the Abruptness of South Asian Summer Monsoon Onset to Convection Aggregation Using SP‐CAM

Abstract A key challenge in understanding South Asian summer monsoon (SASM) onset is to identify how convection–circulation coupling redistributes moist static energy (MSE) before the mature cross‐equatorial monsoon circulation is established. This study aims to explain the varia...

Molecular Engineering of Redox‐Induced Conformational Entropy in Polyviologens for Organic Thermogalvanic Cells

ABSTRACT Thermogalvanic cells are attractive for harvesting low‐grade thermal energy because of their strong thermoelectrochemical response and simple architecture. Because the redox entropy change directly governs their Seebeck coefficient, engineering redox entropy offers an ef...

CYP2D6 as an Emerging Endogenous Oxidative Stress Modulator in Cardiovascular Disease: Genetic, Pharmacological, and Redox Perspectives

Oxidative stress is a central and well-established driver of cardiovascular disease, contributing to mitochondrial dysfunction, endothelial injury, inflammatory activation, and progressive myocardial and vascular remodeling. Although the major endogenous sources of cardiovascular...

Beyond aerosolization: How antibiotic concentration and redox cycling amplify antibiotic resistance genes in wastewater treatment plant bioaerosols

Abstract Wastewater treatment plants are emission hotspots of airborne antibiotic resistance genes, yet the physicochemical drivers of their amplification remain unclear. Here, we quantified airborne antibiotics and oxidative potential (OP) in particulate matter above an aeration...

A Numerical Study on the Motion of Snow Aggregates Freely Falling in Air

Abstract This paper reports the results of the first quantitative study on the flow fields of freely falling snow aggregates. The motions are investigated by performing numerical simulations of four snow aggregate models consisting of 2, 3, 4, and 5 conformally shaped dendrites o...

Selectivity Filter KCND3 Variant Causes Spinocerebellar Ataxia 19/22 and K V 4 .3 Functional Loss

Abstract Background Spinocerebellar ataxia type 19/22 (SCA19/22) is a rare autosomal dominant neurodegenerative disorder caused by KCND3 variants encoding the K V 4.3 potassium channel. While most pathogenic variants result in loss‐of‐function (LOF), no pathogenic variants were p...