National Taiwan University

A population-specific genomic reference panel for Taiwan: NHRI-RP-1

Abstract Background To enhance the efficiency of identifying rare variants within the Taiwanese population and to support genome-wide association studies (GWAS) and imputation studies for genetic risk prediction in the Han population, we have developed the National Health Researc...

A Thrombosed Popliteal Artery Aneurysm Masquerading as a Benign Soft-Tissue Mass: A Case Report Emphasizing the Role of Multimodal Imaging

Popliteal artery aneurysms (PAA) lose their pulsatility once thrombosed and may therefore be mistaken for a Baker cyst or a soft-tissue tumor. A 58-year-old male presented with a 6-month history of progressive right popliteal swelling and pain, accompanied by right foot paresthes...

Tirzepatide Use Is Associated with Reduced Risk of Carpal Tunnel Syndrome in Overweight and Obese Adults

This study aimed to evaluate the association between tirzepatide use and the risk of carpal tunnel syndrome (CTS) and CTS surgery compared with both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and other anti-obesity medications in individuals who are overweight or obese....

Genomic Characterization of Colistin and Fluoroquinolone Resistance in Multidrug-Resistant Escherichia coli from Diseased Food-Producing Animals in Taiwan

Background: The global spread of antimicrobial resistance in Escherichia coli (E. coli) from food-producing animals is a critical concern within the One Health framework, particularly because of the potential transmission of clinically relevant resistance determinants across the...

Integrative analysis of bulk, single-cell, and spatial transcriptomes reveals a clinically relevant transcriptional program from hepatocellular carcinoma to pan-cancer

Abstract Background Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, underscoring the urgent need for robust molecular signatures that support multiple clinical tasks and generalize across diverse transcriptomic platforms. Results We p...

Development and evaluation of a hybrid clinical and deep-learning ECG model for predicting in-hospital cardiac arrest

In-hospital cardiac arrest (IHCA) is often unexpected, and existing early warning scores based mainly on vital signs have limited predictive performance. We developed and internally evaluated clinical, deep-learning electrocardiographic, and hybrid models for IHCA prediction in a...

Modeling suicidal thoughts and behaviors in university students: integrating suicide theory with interpretable machine learning

University students are at risk of suicidal thoughts and behaviors (STB), with prevalence rates higher than those in the general population. Machine learning (ML) enhances the accuracy of STB prediction and provides new possibilities and explanatory frameworks for this issue. Thi...

Vancomycin enriches P arabacteroides goldsteinii in the gut and promotes reconstruction of the hepatobiliary system in cholestasis

Impaired bile secretion disrupts the gut microbiome and perpetuates cholestatic liver injury. Vancomycin (VCM) has been shown to improve cholestasis in human patients, but its biological effects remain unclear. This study aimed to investigate the therapeutic effects of VCM on mic...

Low‐intensity focused ultrasound neuromodulation for drug‐resistant epilepsy: A randomized, sham‐controlled crossover trial

Abstract Objective This study was undertaken to evaluate the safety, feasibility, and efficacy of low‐intensity focused ultrasound (LIFU) as a noninvasive neuromodulation technique in patients with drug‐resistant epilepsy (DRE). Methods In this pilot, single‐blind, randomized sha...

Explaining divergent sustainable finance taxonomies: comparing Taiwan and South Korea

Sustainable finance taxonomies are increasingly used by governments as policy instruments to define environmentally sustainable activities and guide economic transition. How these frameworks are translated into domestic governance arrangements outside Europe remains underspecifie...

Plants, soil, and coexistence: an alternative approach to modelling plant-soil feedback

Abstract Background and Aims Plant-soil feedback (PSF) affects plant coexistence and diversity. Although the current paradigm provides a direct experimental method to quantify PSF and explains coexistence with varying levels of success, the emphasis on pairwise interactions hinde...