Institution
National Taiwan University Hospital
Recent research
- Health & MedicineOpen access
Abstract The adherence of chronic rhinitis patients to self-administered treatments is generally very low, which often presents a significant challenge in healthcare. The adherence of chronic rhinitis patients to regular nasal irrigation hygiene care is even lower. Therefore, in...
- Health & MedicineOpen access
Pesticide self-poisoning accounts for 14%–20% of global suicides. Paraquat, a highly lethal pesticide, is involved in a considerable number of suicides in some countries. This study investigated the burden, trends, geographic variations, and demographic characteristics of pestici...
- Biology
Abstract In nematode sperm, motility is powered by polymerization of major sperm protein (MSP) into filaments assembled from a specialized organelle (FB–MO), but how filament formation begins is unclear. We identify two sperm-specific PDZ proteins, SMZ-1 and SMZ-2 (SMZ-1/2), that...
- BiologyOpen access
Abstract Background Upadacitinib is an oral Janus kinase inhibitor approved for the treatment of moderate-to-severe Crohn’s disease (CD). This post hoc analysis reports the efficacy and safety of upadacitinib for CD in patients in East Asia enrolled in the phase 3 clinical trials...
- Health & MedicineOpen access
Nutritional status may influence the efficacy of ketogenic diet (KD) therapy in children with drug-resistant epilepsy. This study enrolled 43 children (25 girls, 18 boys) with drug-resistant epilepsy. Pre-KD nutritional status was assessed using 24-h diet recalls and 3-day food r...
- Health & MedicineOpen access
Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Adjuvant chemoradiotherapy followed by pembrolizumab (NCT03322267) has been shown to reduce relapses in patients at high risk of recurrence, including those with involved or close margins (≤1 mm), co...
- Health & MedicineOpen access
Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The clinical significance of cervical lymph node (LN) dissection in esophageal squamous cell carcinoma (ESCC) remains uncertain. This study aimed to clarify its clinical rele...
- Health & MedicineOpen access
Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Uniportal robotic-assisted minimally invasive esophagectomy has demonstrated perioperative safety in preliminary experience; however, its oncologic outcomes remain to be established....
- Health & MedicineOpen access
Background Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, but neutropenia concerns continue to limit its use. Large real-world evidence on temporal risk patterns, re-initiation, and patient-level determinants remains limited. Methods We condu...
- Materials & Energy
Abstract Arsine (AsH3) is widely used in semiconductor manufacturing yet poses severe health risks, motivating sensitive on-site monitoring for personnel safety. We report a liquid crystal (LC)-based optical sensor that translates arsine-triggered surface chemistry into an orient...
- Health & Medicine
Early Antiviral Therapy in Pediatric Outpatients and Risk of Influenza-Related Hospitalization
OBJECTIVES: Evidence on the effectiveness of antiviral therapy in preventing influenza-related severe illness and hospitalization among children remains limited. We hypothesized that early administration of antiviral therapy within 48 hours of symptom onset would significantly re...
- Engineering & Technology
Key Determinants of Willingness to Adopt Building Seismic Retrofitting in Taiwan
Abstract In earthquake-prone regions worldwide, enhancing residential seismic resilience is a critical issue, particularly in areas with aging infrastructure. Encouraging public participation in seismic evaluation and retrofitting is essential for disaster risk reduction. However...
- Health & MedicineOpen access
Abstract Background SARS-CoV-2 remains a global health threat because ongoing viral evolution and immune evasion reduce the effectiveness of existing therapies. SNS812 is an inhaled small interfering RNA targeting a highly conserved region of the viral RNA-dependent RNA polymeras...
- Health & MedicineOpen access
Popliteal artery aneurysms (PAA) lose their pulsatility once thrombosed and may therefore be mistaken for a Baker cyst or a soft-tissue tumor. A 58-year-old male presented with a 6-month history of progressive right popliteal swelling and pain, accompanied by right foot paresthes...
- Health & MedicineOpen access
In-hospital cardiac arrest (IHCA) is often unexpected, and existing early warning scores based mainly on vital signs have limited predictive performance. We developed and internally evaluated clinical, deep-learning electrocardiographic, and hybrid models for IHCA prediction in a...
- Health & Medicine
Impaired bile secretion disrupts the gut microbiome and perpetuates cholestatic liver injury. Vancomycin (VCM) has been shown to improve cholestasis in human patients, but its biological effects remain unclear. This study aimed to investigate the therapeutic effects of VCM on mic...
- Health & MedicineOpen access
PURPOSE: This prospective study is designed to test the validity of a multiple-choice question (MCQ) test in assessing theoretical knowledge of ultrasound-guided fine-needle aspiration biosy and core-needle biopsy of the head and neck. METHODS: Seven international experts reached...