National Taiwan University Hospital

Psychometric properties of the paternal breastfeeding self-efficacy scale-short form: a confirmatory factor analysis of fathers in Taiwan

Abstract Background Fathers’ confidence in supporting their partners’ breastfeeding is crucial for successful breastfeeding outcomes. The paternal version of the Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF) is a globally recognised tool for measuring fathers’ perceived...

Optimization of Highway EV Charging Infrastructure Considering Station Attractiveness and User Equilibrium

Abstract The growing adoption of electric vehicles (EVs) has created an urgent need for efficient and user-friendly charging infrastructure. While many studies focus on minimizing costs and travel times, they often overlook the influence of station-specific factors, such as ameni...

Asian Computed Tomography Criteria for Cerebral Amyloid Angiopathy–Related Intracerebral Hemorrhage: Magnetic Resonance Imaging and Pathology Validations

Background The simplified Edinburgh criteria enable diagnosis of cerebral amyloid angiopathy–associated lobar intracerebral hemorrhage when magnetic resonance imaging is unavailable. However, their applicability to Asian populations, which have higher frequencies of deep perforat...

Multifocal mucocutaneous herpes simplex virus type 1 infection temporally associated with seasonal influenza vaccination in a young adult without a known immunocompromising condition: A case report

Seasonal influenza vaccination is widely implemented and generally safe; however, rare immunological adverse events have been reported. We describe a case of multifocal mucocutaneous Herpes simplex virus type 1 (HSV-1) infection temporally associated with seasonal influenza vacci...

Hepatocellular Carcinoma With JAK1 Mutations Harbors Distinct Histologic Features and Specific Mutational Hotspots in an Asian Cohort

The pathogenesis and clinicopathological features of hepatocellular carcinoma (HCC) harboring JAK1 mutation have not been reported. Sixty inflammatory hepatocellular adenoma-like HCCs (IHA-like HCCs) and 16 IHAs were analyzed using targeted next-generation sequencing. Nearly all...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Association Between Unenhanced CT Features and Perioperative Outcomes in Bronchogenic Cyst Resection

Background: Reliable predictors of perioperative risk beyond symptomatology in bronchogenic cyst (BC) resection are lacking. We aimed to compare perioperative outcomes across different imaging features to identify perioperative risk factors. Methods: We conducted a retrospective...

Comparative outcomes of Bernese periacetabular osteotomy in adolescents, young adults, and middle-aged adults

Aims: Bernese periacetabular osteotomy (PAO) is a well-established procedure for symptomatic hip dysplasia in adolescents and young adults. Its application in middle-aged patients remains debated due to concerns regarding complications and uncertain outcomes. This study evaluated...

Bioactive Gold Plasmonic Interfaces Meet Artificial Intelligence: Advancing Saliva‐Based Surface‐Enhanced Raman Spectroscopy Diagnostics

Bioactive gold plasmonic nanostructures are enabling non-invasive saliva diagnostics by amplifying weak Raman signals and converting complex biofluid chemistry into information-rich spectral fingerprints. This Review examines saliva-based Raman and surface-enhanced Raman spectros...

Age-dependent performance of conventional trauma scores in older trauma patients: A retrospective trauma registry study

Population aging has increased the burden of trauma among older adults. Accurate risk stratification remains challenging because age-related physiological vulnerability may reduce the predictive accuracy of conventional trauma scoring systems. Evidence regarding the clinical util...

Young minds in distress: Exploring the global rise in youth mental health diagnoses

Adolescence represents a critical neurobiological period marked by a developmental “mismatch” between early-maturing limbic systems and the later-maturing prefrontal cortex, conferring heightened vulnerability to the onset of psychiatric disorders. This review synthesizes global...

Management of Soft Tissue and Visceral Leiomyosarcomas

Importance Leiomyosarcoma is a rare and heterogeneous malignant mesenchymal neoplasm associated with substantial morbidity and mortality. Given recent advances in biologic understanding and the complexity of leiomyosarcoma, a consensus-driven approach is needed to harmonize manag...

Sodium-glucose cotransporter-2 inhibitors, severe sepsis, and infection-related outcomes in patients with chronic kidney disease and type 2 diabetes

Background: Patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) are vulnerable to infections. While sodium-glucose cotransporter-2 (SGLT-2) inhibitors provide established cardiorenal benefits, their effects on infection remain unclear. This study aimed to evaluat...

Genome-wide association study of estimated glomerular filtration rate using repeated measurements in the Taiwan Biobank

Background: Chronic kidney disease (CKD) is a major global public health issue, with genetic factors playing a significant role in kidney function. Although genome-wide association studies (GWAS) have identified numerous loci associated with estimated glomerular filtration rate (...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

A Scoping Review of Digital Behavioral Approaches to Improve Medication Adherence in Type 2 Diabetes

Abstract Purpose of Review Consistent medication adherence is fundamental for achieving favorable health outcomes in diabetes care; however, attaining optimal adherence remains a challenge. This review summarized recent evidence on digital behavioral interventions designed to imp...

Synthesis and Application of 3,3-Difluoro Sialic Acid as a Sialyltransferase and Neuraminidase Inhibitor

Abstract Sialic acid (Neu5Ac) is a monosaccharide terminating glycoconjugates, serving as ligands for lectins in health and disease. Tools to target sialyltransferases (STs) and neuraminidases (NEUs) are important in the study of sialoglycans. 3FaxNeu5Ac is a common ST inhibitor,...

Hydrothermally Grown NiFe Layered Double Hydroxide on Hastelloy Fiber Paper for the Oxygen Evolution Reaction in Anion-Exchange Membrane Water Electrolysis

Abstract Hastelloy fiber paper (HAP) exhibits excellent corrosion resistance, electrical conductivity, and structural robustness; however, its application as a porous transport layer (PTL) in water electrolysis systems remains relatively underexplored. In this study, a highly act...

Cilostazol Treatment for Intracerebral Hemorrhage: Targeting Dural Lymphatics

BACKGROUND: The meningeal lymphatic system contributes to hematoma resolution and neurological recovery after intracerebral hemorrhage (ICH). We previously demonstrated that intraperitoneal cilostazol administration promotes dural lymphatic growth and enhances clearance of intrac...

Impact of Baseline Synchronous Adenoma Burden on the Risk of Metachronous Advanced Neoplasia

Background and study aim: Individuals classified as “high-risk” at initial colonoscopy face an elevated risk of metachronous advanced colorectal neoplasms (meta-ACRN), but risk heterogeneity within this group remains unclear. We aimed to stratify meta-ACRN risk among high-risk in...