National Research Council

Rationally Designed Phenyl- and Phenanthryl-Based Imidazole Hybrids for the Treatment of Breast Cancer—A Structure–Activity Relationship Study

A series of 11 compounds of phenyl–imidazole–pyrrole and 9 compounds of phenanthryl–imidazole–pyrrole were synthesized and evaluated against breast cancer cell lines differing in the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth facto...

Unveiling the Microbial Community of Naturally Fermented Bella di Cerignola PDO Table Olives Integrating Culture-Dependent, MALDI-TOF MS Identification and Long-Read Metabarcoding Approaches

Spontaneous fermentation of table olives is driven by complex microbial communities that influence product quality and safety. This study investigated the microbial community during the intermediate and late stages (from 3 to 6 months) of spontaneous fermentation of Bella di Ceri...

A GPRC5B–Fyn signaling axis regulates VRAC activity by targeting LRRC8A

The mechanisms by which physiological signals gate the volume-regulated anion channel (VRAC) remain poorly understood. Here, we identify a GPRC5B–Fyn signaling axis that directly controls VRAC activation by targeting the essential subunit LRRC8A. We found that the orphan G protei...

A Machine Learning Framework for Objective Definition and Projection of Meteorological Seasons: An Application to the Indian Subcontinent

Abstract Meteorological seasons are typically defined through fixed calendar intervals or region‐specific thresholds, yet such approaches fail to capture the actual variability of the annual cycle. Here we present a machine learning framework that objectively detects meteorologic...

Airflows redefine the cost of aerial transport in the wild

Fuel economy matters to both animals and machines, as the cost of transport can determine where, when, and how far locomotion is possible. However, established estimates of these values for animal flight come from laboratories and treat the atmosphere as constant, even though fre...

The OpenSat4Weather dataset: Ku-band satellite link data for precipitation monitoring

Abstract. The TV-SAT signals received by the ground antennas of Satellite Microwave Links (SMLs) can be opportunistically used for identifying and quantifying precipitation. Hence, SMLs can serve as low-cost rainfall sensors complementary to conventional instruments. However, a s...

Characterizing End-User Auditing of Recommender System Behaviors Affecting Music Discoverability: a Diary Study

Recommender systems shape what people encounter online, yet their role in facilitating or constraining music discoverability is rarely examined from the listener’s perspective. To help address this gap, we present a two-week diary study with nine Italian young adults who reported...

Microplastics and the Kidney: A Narrative Review of Human Evidence, Molecular Mechanisms of Cell Injury, and Future Directions

Microplastics (MPs) are widespread environmental contaminants, but their potential effects on kidney health remain poorly defined. As an organ continuously exposed to circulating particles and involved in their urinary elimination, the kidney may represent both a target of MP tox...

Structural and functional insights into the recombinant PR-10 tomato allergen Sola l 4.02

Abstract Sola l 4.02 is a major tomato allergen of the PR-10 family and a Bet v 1 homolog implicated in pollen–food cross-reactivity, yet its molecular properties remain poorly defined. Here, we report the recombinant production and its comprehensive structural and functional cha...

Wax-treated hemp fabrics to reduce water absorption in PLA/PBSA laminated composites

Biocomposites with natural fibres have generated considerable interest thanks to their environmental sustainability. Nevertheless, their use in humid environments remains limited. This study investigates a blend of poly(lactic acid) (PLA) and poly(butylene succinate) (PBSA) reinf...

Reconciling intrinsic and ecosystem water-use efficiency reveals physiological mechanisms underlying carbon-water coupling across biological scales

Understanding how carbon-water coupling scales from leaves to ecosystems remains a major challenge because water-use efficiency (WUE) metrics integrate physiological, hydrological, and ecological processes. We integrated tree-ring width, triple stable isotopes (δ13C, δ18O and δ2H...

Provenance and competence for CHIKV and DENV of Aedes albopictus populations

Aedes albopictus is one of the world’s most hazardous invasive species, increasingly implicated in the autochthonous transmission of Chikungunya (CHIKV) and Dengue (DENV) viruses in newly colonized areas. Since invading the Mediterranean Basin several in the early 1980s, recurren...

Plant Proteins and Bioactive Peptides: Distinguishing Nutritional Quality from Sequence-Dependent Bioactivity

Plant proteins represent both important nutritional resources and reservoirs of encrypted bioactive peptide sequences. However, protein nutritional quality and peptide bioactivity are distinct properties: a favorable indispensable amino acid profile or high digestibility does not...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

Drivers governing the seasonality of new particle formation in the Arctic

New particle formation (NPF) is the phenomenon wherein gaseous precursors form critical clusters of barely a few nanometres in diameter, after which, under favourable conditions, these particles can grow to climate-relevant sizes. Here we present measurements from 2022 to 2024 of...

I casi studio per testare utilità e validità dell'Atlante Aria Salute: definizione del quadro concettuale.

OBJECTIVES: to describe the process of selecting and applying a shared conceptual model for the analysis of case studies designed to test the usefulness and validity of the Air and Health Atlas in supporting decision-making, in its current version and in its potential future deve...

Exogenous L-Citrulline Increases Tolerance to Tomato Brown Rugose Fruit Virus in Tomato Plants

Tomato brown rugose fruit virus (ToBRFV) is one of the most aggressive viral pathogens affecting commercial tomato cultivars, causing severe economic losses worldwide. Since plant viral diseases cannot be effectively controlled with pesticides, alternative strategies aimed at red...

Adeno‐associated virus ‐mediated restoration of Na V 1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of Na V 1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures,...

Structural dynamics and pH ‐regulated membrane binding of the TRAF2 ‐ NC trimer

Tumor necrosis factor receptor-associated factor 2 (TRAF2) is a key adaptor in TNF receptor-signaling that operates as a trimeric assembly. Here we investigate the structural and functional properties of a TRAF2 construct spanning the trimerization and receptor-binding domains (T...

Federated EGA in the European and Global Human Data Ecosystem

This Federated EGA in the European and Global Human Data Ecosystem white paper sets out our vision for the future role of Federated EGA (FEGA) in supporting secure, responsible and FAIR reuse of controlled-access human data. It describes how FEGA has developed into an operational...