National Institute of Health Sciences

Development of YO-01027-Derived Signal Peptide Peptidase Inhibitors with Reduced γ-Secretase Inhibition

Abstract Signal peptide peptidase (SPP) is an endoplasmic-reticulum intramembrane aspartyl protease required for hepatitis C virus (HCV) core protein maturation, but many SPP inhibitors also inhibit γ-secretase. Here, we designed YO-01027-derived dibenzazepinone analogs to retain...

Comparison of the Sensitivity of Histopathological and Immunohistochemical Analyses With That of Serum Hormone Measurements for Early Detection of Antithyroid Effects in Rats Treated With Iodide Uptake Inhibitors

ABSTRACT Serum thyroxine (T4), triiodothyronine (T3), and thyroid‐stimulating hormone (TSH) measurements are widely used to detect antithyroid effects in rodent toxicity studies. However, the assays used to measure these hormones are costly and highly variable depending on the bl...