National Institute of Health

Umbilical cord red blood cell transfusions in very premature neonates: A physiologically aligned transfusion strategy

The authors have disclosed no conflicts of interest. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Comparative pathogenicity study of monkeypox virus Clade Ib and Clade IIb in a rabbit model

Manuscript data for review

Antidepressants and breast cancer risk: a meta-analysis of exposure windows and cumulative use in nearly two million women

Abstract Background The use of antidepressants is steadily increasing worldwide. This trend has a significant impact on public health and socioeconomic conditions. Although studies have looked for a possible link between antidepressants and breast cancer risk, findings remain unp...

Advanced molecular poliovirus diagnostics across multiple real-time PCR platforms with locked nucleic acids and primer overhangs

This study details the development and validation of five real-time RT-PCR assays for the intratypic differentiation (ITD) of polioviruses and the discrimination of vaccine-derived polioviruses (VDPVs) utilizing locked nucleic acid (LNA) technology and primer overhangs. Updated a...

Patient-centred and fit-for-purpose clinical trials in rare cancers: lessons from sarcomas for operationalising 2024 WHO Guidance and ICH E6(R3)

Rare cancers account for approximately one quarter of cancer diagnoses in Europe, yet prevailing clinical trial governance frameworks were developed for common malignancies and conventional randomised designs. The 2024 WHO Guidance for best practices for clinical trials and ICH E...

Post-tuberculosis lung disease in children and adolescents: Myth or reality – A narrative review

Childhood tuberculosis (TB) remains a major cause of morbidity and mortality in high-burden settings, with Africa carrying a disproportionate share of incident and undiagnosed disease. A longstanding cure-centered paradigm has reinforced the notion that post-TB lung disease (PTLD...

A Programmable Nanovesicle Platform for MegapascalPressure Sensing

Abstract Hydrostatic pressure (HP) is a subtle yet pervasive force that shapes chemistry and biology from the ocean floor to living cells─yet real-time HP sensing at the microscale remains elusive. Here, we report pyrene-modified polyionic complex vesicles (Pyr-PICsomes) as a cla...