National Clinical Research

Intratubular light chain amyloidosis: a comprehensive analysis of disease spectrum and clinicopathological characteristics

Abstract Background The disease spectrum of intratubular light chain amyloidosis (AL) remains unkown. Methods Patients with intratubular AL from a single center were retrospectively analyzed and stratified into 3 groups: Group 1, complicated by extra-tubular amyloidosis; Group 2,...

Functional effects of microbial metabolites in dental caries

Dental caries is a multifactorial disease primarily driven by the metabolic activity of microorganisms within oral biofilms. The carious process begins when fermentable carbohydrates are metabolized by microbes, leading to the production of organic acids that lower the local pH a...

Merging artificial intelligence and retinal vascular geometric parameters: A novel tool for diagnosis and prognosis prediction of diabetic nephropathy

Abstract Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. The retinal microvasculature, as the only directly observable microvasculature, may reflect DN progression. This study aims to construct a non-invasive diagnostic and prognostic predic...

3D-printed biochemical–biomechanical gradient scaffolds from high internal phase Pickering emulsion with dual gelatin-modulated gelling kinetics for enhanced osteochondral regeneration

Three-dimensional (3D) printing enables the precise design of biomaterials at predefined spatial locations, representing a promising strategy for constructing highly organized osteochondral tissue with multiple morphogen gradients. However, most current 3D printing strategies lim...

Immune-inflammatory biomarkers for in-hospital mortality risk stratification in older patients with sepsis: a multicentre leave-one-hospital-out validation study

Older adults with sepsis have high mortality, but whether circulating immune-inflammatory biomarkers improve prediction beyond routine clinical information across hospitals is uncertain. We analysed 816 patients aged ≥ 60 years from a prospectively assembled multicentre cohort at...

Crestal total tissue thickness as a potential predictor of early gingival recession after anterior immediate implant placement and provisionalization: a retrospective study

To preliminarily evaluate total tissue thickness at the level of the alveolar ridge crest (TT RC ) as a potential preoperative predictor of early gingival recession (GR) following immediate implant placement and provisionalization (IIPP) in the maxillary aesthetic zone. This retr...

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

ABSTRACT Epstein‐Barr virus (EBV) is a key oncogenic driver of nasopharyngeal carcinoma (NPC) and is closely associated with cisplatin resistance, but its roles in metabolic reprogramming and chemoresistance remain unclear. This study aimed to investigate the role of EBV in polya...

Association between heart rate, metoprolol use, and clinical outcomes in patients with heart failure and chronic obstructive pulmonary disease

Elevated heart rate is a recognized prognostic marker in heart failure (HF), and beta‑blockers are recommended to control heart rate. However, real-world data on discharge heart rate, beta-blocker dosing, and their prognostic associations in patients with concomitant HF and chron...

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K /Akt/ mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Clostridioides difficile infection (CDI) remains a major cause of antibiotic-associated colitis and is characterized by excessive intestinal inflammation, epithelial barrier disruption and impaired mucosal repair. Although sodium butyrate (NaB), a microbiota-derived short-chain f...

Immune profiling of chronic recurrent non-specific parotitis using CyTOF: a preliminary exploratory study

Chronic recurrent non-specific parotitis (CRNP) is characterized by recurrent parotid swelling and pain without identifiable obstructive lesions or systemic autoimmune diseases. The immunological features underlying CRNP remain poorly defined. Peripheral blood mononuclear cells (...

From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease

Panvascular diseases (PVDs) stand as the leading cause of global mortality, necessitating a paradigm shift from local anatomical repair to the systemic restoration of vascular homeostasis. While intravascular optical imaging has revolutionized diagnosis, it remains a passive obse...

Transverse V-Y Mucosal Advancement Flap for Reconstruction of Labial Mucosal Defects: A Clinical Application

OBJECTIVE: To evaluate the clinical efficacy of the transverse V-Y advancement mucosal flap for reconstruction of small- to medium-sized lip mucosal defects. METHODS: Clinical data from 17 patients who underwent reconstruction of lip mucosal defects following resection of benign...

Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology

Orthodontic treatment corrects various craniofacial malformations primarily through triggering active alveolar bone remodeling, however the potential impacts of this intervention on the systemic immune state have long been insufficiently explored. Here, we show that mechanical fo...

Hepatic GPR110 plays a complex and context-dependent role in metabolic dysfunction-associated steatotic liver disease

Metabolically-dysfunction-associated steatotic liver disease (MASLD)—formerly known as nonalcoholic fatty liver disease (NAFLD) —is now the most common chronic liver disease worldwide, affecting more than 30% of the global population. Recent studies have documented seemingly cont...