National Clinical Research

Unleashing the Potential of Autologous Platelet Concentrates in Bone Regeneration: A Focus on Their Synergy With Biomaterials

ABSTRACT Bone defects present significant clinical challenges worldwide, as conventional treatments such as autografts and allografts are constrained by limited supply, immune risks and insufficient bioactivity. Derived from the patient's own venous blood via centrifugation, auto...

Between-cohort variation in the cardiovascular association and predictive utility of the triglyceride-glucose waist circumference index among ageing adults in China, England, and the United States

Low-cost metabolic indices could support cardiovascular screening, but their utility may vary across populations. We evaluated between-cohort variation in the association, incremental predictive value, and absolute-risk performance of the triglyceride-glucose waist circumference...

Disease‐Specific Optimal Blood Glucose Control Strategies in Critically Ill Patients: Retrospective Cohort Study and Network Meta‐analysis

ABSTRACT Background Optimal glucose targets for critically ill patients are likely to vary by underlying condition, yet a ‘one‐size‐fits‐all’ approach persists. Aim Determining disease‐specific glucose thresholds may help achieve the lowest mortality rates. Study Design This stud...

Modulating Activation Strain Thresholds in Mechanochromic Polymers through the Prestretching Strategy

Abstract Mechanochromic polymers provide a powerful tool for visualizing stress distribution and signaling mechanical damage through force-induced optical responses. However, their practical applications are often restricted by the relatively high activation strain threshold, whi...

Young bone marrow mesenchymal stem cell-derived exosomes promote perfusion recovery and tissue repair via the miR-455-5p/Bach1 axis after hindlimb ischemia

Lower-limb ischemia caused by peripheral arterial disease (PAD) results in sustained perfusion impairment and tissue injury, and effective regenerative therapies remain limited. Bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos) are a promising cell-free therapeutic s...

Complex metatarsal defect reconstruction with vascularized bone and soft-tissue flaps

Complex metatarsal defects, particularly those accompanied by soft-tissue loss, are difficult to reconstruct because both skeletal continuity and durable wound coverage must be restored. Existing evidence is largely limited to isolated case reports and small series with short fol...

Development of a Self-administered Sexual Behavior Assessment Tool to Facilitate Self-reflection by Young Women in South Africa About HIV/STI Risk

Abstract Self-assessment of sexual behavior may empower adolescent girls and young women (AGYW) to reflect on HIV/STI risk and adopt prevention strategies. We developed a web-based sexual behavior self-assessment tool providing real-time feedback based on a numeric score and exam...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...

An in vitro study of a novel chitosan hydrogel blocking agent to prevent microbial leakage via abutment screws of dental implants

Microbial leakage at the implant–abutment–screw interface contributes to biological and mechanical complications in dental implant therapy. A novel chitosan hydrogel (Chitosan-Na 2 CO 3 , CS) against Candida albicans and Enterococcus faecalis to prevents microbial leakage at the...

Interferon Regulatory Factor 1 Inhibits the Adipogenic Differentiation of BMSCs via the AMPK – mTOR Signaling Axis and Induces Their Autophagy to Alleviate Osteoporosis‐Related Bone Marrow Adiposity

ABSTRACT Increased bone marrow adiposity is a characteristic of osteoporosis and negatively regulates osteogenesis. Bone marrow mesenchymal stem cells (BMSCs) give rise to bone marrow adipocytes. The transcription factor interferon regulatory factor 1 (IRF1) modulates multiple bi...

Resveratrol Maintains Hippocampal Mitochondrial Function and Inhibits Neuronal Ferroptosis to Improve Diabetes-Associated Cognitive Dysfunction via Sirt1/Shh Signaling

Background Resveratrol has been shown to play a neuroprotective role in diabetic cognitive dysfunction. We determined whether resveratrol improved diabetic cognitive dysfunction through ferroptosis regulation, and explored the potential mechanism. Methods Rats were fed with a hig...

Donor‐Site Outcomes of the Superficial Circumflex Iliac Artery Perforator Flap Versus Radial Forearm Flap in Unilateral Tongue Reconstruction: A Propensity Score Matching Analysis

ABSTRACT Background We compared the superficial circumflex iliac artery perforator (SCIP) flap with the radial forearm flap (RFF) to identify limitations restricting its widespread use. Methods We retrospectively evaluated unilateral tongue reconstruction using propensity score m...

Facilitators and barriers influencing the implementation of type 2 diabetes remission programmes: a qualitative meta-synthesis from a multi-stakeholder perspective

Although type 2 diabetes (T2D) remission has emerged as a promising therapeutic goal, its implementation in real-world settings faces considerable challenges. Understanding the perspectives of multiple stakeholders is essential to address these implementation challenges. This met...

Library strategies differentially shape microbial, functional, and host signals in clinical metagenomic sequencing

Metagenomic next-generation sequencing (mNGS) is increasingly used in infectious disease diagnostics, yet how library preparation shapes the microbial, functional, and host signals recovered from clinical samples remains poorly defined. Here, we performed a within-sample parallel...

Recent advances in delivery strategies for CRISPR-based genome editing

Abstract The rapid development of CRISPR genome editing technologies has established a transformative paradigm within biomedical research, drug discovery, and gene therapy. Despite the robust nuclease activity and programmable targeting exhibited by these systems, the clinical tr...

20-year experience of biomet stock alloplastic temporomandibular joint replacement in Chinese patients after technical modifications: a single-center retrospective study.

OBJECTIVES: To evaluate the clinical and radiographic outcomes of the Biomet stock alloplastic temporomandibular joint replacement (ATJR) after seven progressive surgical modifications in Chinese patients at a single center. MATERIALS AND METHODS: Patients who underwent ATJR from...

Ticagrelor-Aspirin With Thrombolysis by Infarct Patterns in Moderate Ischemic Stroke: TAPIS Subgroup Analysis

BACKGROUND: Whether diffusion‑weighted imaging infarction patterns influence the efficacy and safety of early oral ticagrelor‑aspirin with intravenous thrombolysis in moderate acute ischemic stroke is uncertain. We assessed treatment effects by infarction pattern in this thrombol...

Nighttime Sensory–Behavioral Activation and Admission Suicidality in Young Inpatients With Major Depressive Disorder: A Retrospective Clinical‐Record Study

INTRODUCTION: Suicide risk assessment during psychiatric admission may benefit from clinically observable information beyond overall depressive symptom severity. This study examined whether clinician-documented nighttime sensory-behavioral activation was associated with admission...

Sprayable NIR/pH-responsive NSC/PF127 hydrogel loaded with MoO₂, ciprofloxacin, and FGF-2 for enhanced antibacterial and pro-regenerative infected wound healing

Infected wounds represent a significant clinical burden owing to persistent infection, excessive inflammation, and impaired tissue regeneration. To overcome these limitations, we developed a sprayable N-succinyl chitosan/Pluronic F127 (NSC/PF127) hydrogel incorporating MoO₂ nanop...

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...