Nantong University

A 128−Channel 0.2–8.2 V Calibrated DAC IC Achieving 0.26−LSB DNL and 0.71−LSB DVO for Photonic Computing

Photonic computing systems require large numbers of accurate programmable voltages for photonic weight programming and device bias control. This paper presents a 128−channel digital−to−analog converter (DAC) implemented in a 250 nm BCD high−voltage CMOS process. A code−dependent...

UA-30 ameliorates motor deficits through RalA-mediated mitophagy in ALS mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, skeletal muscle atrophy, paralysis, and eventually death. Mitochondrial dysfunction plays a pivotal role in ALS pathogenesis, although the precise pathogenic mechani...

Water‐driven dispersible fiber electrode arrays for position‐dependent intracardiac electrophysiological recording

Abstract Intracardiac electrophysiological recording plays an essential role in identifying abnormal cardiac electrical activity and guiding arrhythmia diagnosis and treatment planning. A key challenge for minimally invasive intracardiac electrodes is to combine reliable transvas...

Circulating miR-106b-5p discriminates acute myocardial infarction patients, predicts disease severity, and regulates H/R-induced cardiomyocyte injury by targeting CDKN1A

The early detection, disease monitoring, and prognosis prediction are of great significance for acute myocardial infarction (AMI). This study focused on miR-106b-5p, evaluating its clinical significance in AMI onset and progression. This study enrolled 147 AMI patients with 123 s...

Taurine-loaded extracellular vesicles suppress mtDNA–cGAS–STING signaling by enhancing SIRT1-dependent mitophagy to alleviate neuronal senescence after spinal cord injury

Spinal cord injury (SCI) triggers a cascade of secondary pathological processes that lead to progressive neuronal dysfunction and impaired functional recovery. Although cellular senescence has been increasingly implicated in neurodegenerative conditions, its role in SCI remains p...

Super Twisting Observer-Based Fast Terminal Sliding Mode Control with Dual-Term Hyperbolic Reaching Law: Experimental Validation on Buck Converter

This paper proposes a super twisting observer-based fast terminal sliding mode control scheme with a novel dual-term reaching law for output voltage regulation of a DC–DC buck converter under disturbances. The proposed reaching law replaces the discontinuous sign function with a...

Context-dependent functional diversity of dorsomedial posterior parietal neurons revealed by single-unit fMRI mapping during naturalistic viewing

Abstract The dorsomedial posterior parietal cortex (dmPPC) plays an important role in episodic processing by integrating sensory, cognitive, and motor information across distributed brain systems. However, how individual dmPPC neurons participate in large-scale functional organiz...

Advances in Confined Catalysts for Methane Dry Reforming: From Design Strategies to Reaction Mechanisms

Abstract Dry reforming of methane (DRM) converts two major greenhouse gases, CH4 and CO2, into syngas. The products (CO and H2) can be directly utilized as feedstock for chemical processes such as Fischer–Tropsch synthesis and methanol production. Transition metal-based catalysts...

Development of an explainable machine learning model for predicting six-month consciousness recovery in patients with prolonged disorders of consciousness

With advances in emergency care systems, the number of patients with prolonged disorders of consciousness (pDoC) has markedly increased. To optimize the allocation of healthcare resources and mitigate risks, the early and accurate identification of recovery potential in pDoC is e...

DPP9 modulates RPA1 stability and temozolomide sensitivity through RFWD3 Nuclear localization in glioma

Temozolomide resistance is a major barrier to effective glioma treatment and is frequently associated with enhanced DNA damage repair capacity. Although DPP9 has been linked to tumor development in several malignancies, whether it contributes to glioma therapeutic resistance has...

Interdependencies among factors related to participation in smart home-based elderly care platforms in China: an exploratory social network analysis

Despite increasing policy investment in smart home-based elderly care platforms, participation among older adults and care institutions remains limited. Existing studies have primarily examined participation-related factors from either the demand or supply side, but have paid lim...

Surgical outcomes and prognostic factors in elderly Chinese patients with valvular heart disease: a multi-center retrospective cohort study

Abstract Objective To investigate surgical outcomes and prognostic factors in elderly patients (≥ 60 years) with valvular heart disease (VHD) undergoing surgery, and to provide evidence for optimizing clinical decision-making. Methods A retrospective analysis was conducted on 347...

Glycolytic Reprogramming in Parkinson's Disease: From Bioenergetic Crosstalk to Therapeutic Modulation

ABSTRACT Parkinson's disease (PD) is increasingly recognized not merely as a localized proteinopathy, but as a systemic metabolic disorder driven by bioenergetic failure. While mitochondrial dysfunction is a well‐established pathological hallmark, the compensatory reprogramming o...

Rare-Earth-Encapsulated Phosphotungstates with Dawson and Lindqvist Units for Catalytic Oxidation of Benzyl Alcohol

Abstract Three rare-earth-embedded phosphotungstates with a dimeric sandwich structure containing two types of building blocks (BBs) [NH2(CH3)2]11H[RE(P2W17O61)(W5O18H)]·9H2O [RE = Dy3+ (1), Er3+ (2), Pr3+ (3)] have been synthesized via a one-pot self-assembly strategy. A distinc...

Stackelberg Game-Based Optimal Operation of a Flexible Integrated Energy System with Dual Energy Storage for Source-Load Interaction

Renewable-energy fluctuations and the conflicting economic objectives of independent stakeholders pose simultaneous physical and market challenges to the operation of flexible integrated energy systems (FIESs). To address these issues, this paper develops a market–physical couple...

The macroeconomic impact of Chinese economic uncertainty in East Asia: evidence from a large multi-economy TVP-VAR model

This paper examines the spillover effects of Chinese economic uncertainty on Japan, South Korea, and Taiwan, set against the backdrop of China’s structural transition and rising geopolitical tensions. Using a large multi-economy time-varying parameter vector autoregressive model...

The dialectic tension between traffic and norms: content creators’ participation in vernacular architectural heritage restoration — evidence from the Qing-dynasty Jin-style “Shanxi Old Residence”

The rapid growth of short-video platforms has transformed vernacular architectural conservation from a professional field into mass public discourse, where online content creators act as vital grassroots practitioners that popularize traditional construction culture through intui...

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

ABSTRACT Chimeric antigen receptor (CAR)‐engineered cell therapies are being extended from hematological malignancies to autoimmune, inflammatory, and fibrotic diseases, although the maturity of evidence differs markedly among platforms and indications. Early clinical evidence fr...

CT quantification of enlarged inguinal lymph nodes as a diagnostic approach for periprosthetic joint infection after hip arthroplasty

Periprosthetic joint infection (PJI) is a major complication following total hip arthroplasty (THA), posing significant diagnostic challenges. This study prospectively evaluated 114 patients from January 2021 to August 2023, including those with PJI and aseptic loosening, using c...

Trajectories of Kinesiophobia and Influencing Factors in Patients With Acute Myocardial Infarction

It is widely acknowledged that kinesiophobia is prevalent among patients suffering from acute myocardial infarction (AMI). Although heightened kinesiophobia significantly predicts adverse outcomes, it should be recognized that this fear is dynamic and typically evolves during the...