Nanjing Drum Tower Hospital

Dynamic coordination engineering of gallium biomaterials: A biological accessibility framework for therapeutic biofunction

Gallium (Ga)-based biomaterials have emerged as versatile therapeutic platforms owing to the iron-mimicking properties and broad biological activities of gallium. Coordination engineering regulates Ga speciation, stability, transport, and therapeutic activation; however, optimizi...

Teriparatide alleviates limb ischemia-associated posttraumatic bone loss: potential involvement of the AKT/HIF-1α/VEGFA signaling axis

Posttraumatic bone loss is a common clinical complication characterized by localized osteopenia and microstructural degradation after traumatic injury. However, its precise pathogenesis remains unclear. Teriparatide (TPTD), administered intermittently, exerts potent pro-osteogeni...

A Homozygous Variant in DMRTB1 Is Associated With Non‐Obstructive Azoospermia in Humans

ABSTRACT Non‐obstructive azoospermia (NOA) represents the most severe form of male infertility, and the pathogenesis in partial patients can be attributed to endocrine dysfunction or heritable genetic variants. Although the application of whole‐exome sequencing (WES) has facilita...

Taurine-loaded extracellular vesicles suppress mtDNA–cGAS–STING signaling by enhancing SIRT1-dependent mitophagy to alleviate neuronal senescence after spinal cord injury

Spinal cord injury (SCI) triggers a cascade of secondary pathological processes that lead to progressive neuronal dysfunction and impaired functional recovery. Although cellular senescence has been increasingly implicated in neurodegenerative conditions, its role in SCI remains p...

HMMR+ stromal cells drive human uterine development

Abstract Early uterine development in humans is a critical determinant of reproductive health and disease susceptibility during adolescence. While single-cell analyses have extensively characterized the adult uterus, the developmental origins of this organ remain poorly understoo...

A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer

Abstract Background The therapeutic potential of oncolytic adenoviruses (ADVs) in colorectal cancer is constrained by a counterproductive host response: virus-triggered hyperactivation of the pro-survival AKT pathway, which fosters an immunosuppressive tumor microenvironment. Met...

QT Prolongation, Ventricular Arrhythmia, and Cardiac Arrest Signals During Ceftriaxone Co-therapy with Individual Proton Pump Inhibitors: A Multidatabase Study

The concomitant use of ceftriaxone and proton pump inhibitors (PPIs) is common in hospital practice. However, it is unclear whether individual PPIs differ in their effects on QT interval prolongation, ventricular arrhythmia, or cardiac arrest, collectively termed as QVC events. W...

Tumor necrosis and ascites on baseline 18F-FDG PET/CT as independent prognostic imaging markers for double/triple-hit lymphoma.

OBJECTIVE: F-FDG) positron emission tomography/computed tomography (PET/CT) in DHL/THL patients. SUBJECTS AND METHODS: . RESULTS: =18.369, P<0.001, respectively) in subgroup analyses of patients treated with R-CHOP and intensive regimens, respectively. CONCLUSION: independently p...

Surgical outcomes and prognostic factors in elderly Chinese patients with valvular heart disease: a multi-center retrospective cohort study

Abstract Objective To investigate surgical outcomes and prognostic factors in elderly patients (≥ 60 years) with valvular heart disease (VHD) undergoing surgery, and to provide evidence for optimizing clinical decision-making. Methods A retrospective analysis was conducted on 347...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Development and internal validation of a nomogram for predicting sepsis risk in neonates with pneumonia

To develop and internally validate an individualized model for predicting sepsis risk in neonates with pneumonia and to support early risk stratification at admission. Clinical records of 817 neonates with pneumonia admitted to the Department of Neonatology, Jiangsu Province (Suq...

Multi-omics integration reveals human placental molecular signatures associated with microplastics exposure

Abstract Background Microplastics (MPs) are pervasive environmental contaminants that have been increasingly detected in human tissues. However, their molecular effects on the human placenta, a critical interface for maternal–fetal exchange and fetal development, remain poorly un...

Chinese herbal medicine (Yiqi Huayu Jiedu Decoction) combined with chemotherapy for preventing postoperative recurrence and metastasis in elderly gastric cancer patients: protocol for a multicenter, double-blind, randomized, placebo-controlled trial

Abstract Introduction Gastric cancer (GC) has a generally unfavorable prognosis. Elderly patients often tolerate dual-drug chemotherapy poorly, experience limited benefits from monotherapy, and face high rates of postoperative recurrence and metastasis. To address this unmet clin...

A Validated, explainable machine learning–based preoperative risk model for microvascular invasion in hepatocellular carcinoma

Abstract Purpose This investigation aimed to develop and validate a diagnostic algorithm for preoperatively assessing the likelihood of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). Methods Clinical and pathological information of patients with HCC...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Serum proteomic profiling reveals LPA As a biomarker for paraspinal muscle fat infiltration in degenerative lumbar kyphosis

Paraspinal muscle fat infiltration (PMFI) plays a crucial role in the onset and progression of degenerative lumbar kyphosis (DLK). Dynamic identification and validation of serum potential biomarkers could facilitate assessment of PMFI status. A total of 47 patients with DLK and 4...

The hDPSC-CM-derived peptide P1DC promotes osteogenic differentiation by regulating the p38/MAPK pathway

Human dental pulp stem cells (hDPSCs) are dental-derived mesenchymal stem cells with robust multipotent differentiation potential, indicating that they are promising for bone tissue engineering (BTE). We previously screened a secreted peptide, P1DC, derived from differentiated hD...

Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes

Excessive dietary fructose consumption contributes to the rapidly increasing prevalence of obesity, metabolic syndrome, and chronic kidney disease worldwide, and accumulating preclinical evidence has confirmed that excess fructose exposure provokes severe mitochondrial dysfunctio...

Temporal Profiles and Clinical Associations of Lipoprotein and Apolipoprotein Profiles in Critically Ill Patients with Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PIICS): A Retrospective Cohort Study

Persistent inflammation, immunosuppression, and catabolism syndrome (PIICS) is a severe complication in critically ill patients, accompanied by profound disturbances in lipid metabolism. However, the sequential changes in these lipoproteins and apolipoproteins and their associati...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...