Nanjing Drum Tower Hospital

The hDPSC-CM-derived peptide P1DC promotes osteogenic differentiation by regulating the p38/MAPK pathway

Human dental pulp stem cells (hDPSCs) are dental-derived mesenchymal stem cells with robust multipotent differentiation potential, indicating that they are promising for bone tissue engineering (BTE). We previously screened a secreted peptide, P1DC, derived from differentiated hD...

Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes

Excessive dietary fructose consumption contributes to the rapidly increasing prevalence of obesity, metabolic syndrome, and chronic kidney disease worldwide, and accumulating preclinical evidence has confirmed that excess fructose exposure provokes severe mitochondrial dysfunctio...

Temporal Profiles and Clinical Associations of Lipoprotein and Apolipoprotein Profiles in Critically Ill Patients with Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PIICS): A Retrospective Cohort Study

Persistent inflammation, immunosuppression, and catabolism syndrome (PIICS) is a severe complication in critically ill patients, accompanied by profound disturbances in lipid metabolism. However, the sequential changes in these lipoproteins and apolipoproteins and their associati...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Machine learning-based identification of blood lipid-related factors associated with COPD among non-smoking women in the Yili region of Xinjiang, China

Abstract Objective Chronic obstructive pulmonary disease (COPD) in non-smoking women, particularly in rural regions, remains poorly understood. This study employed machine learning to identify key associated factors for COPD among never-smoking women in the Yili region of Xinjian...

Photo‐Generated 1 O 2 Triggers In Situ RNA Crosslinking for High‐Contrast Tumor MRI and Effective Tumor Suppression

ABSTRACT High‐contrast imaging and effective treatment of hepatocellular carcinoma (HCC) remain challenging, largely due to the limited tumor selectivity of existing contrast agents and the absence of stable and broadly conserved therapeutic targets. Herein, we report a photoacti...

Photo‐Generated 1 O 2 Triggers In Situ RNA Crosslinking for High‐Contrast Tumor MRI and Effective Tumor Suppression

ABSTRACT High‐contrast imaging and effective treatment of hepatocellular carcinoma (HCC) remain challenging, largely due to the limited tumor selectivity of existing contrast agents and the absence of stable and broadly conserved therapeutic targets. Herein, we report a photoacti...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias

The molecular mechanisms by which KMT2A-rearranged (KMT2A-r) leukemias maintain the oncogenic FLT3 expression remain largely unclear, limiting therapeutic opportunities. Here, we identify the RNA binding protein MBNL1 as an unexpected positive regulator of FLT3 by DepMap dataset...

A target-based population pharmacokinetic and pharmacodynamic analysis for intra-articular dosing regimen optimization of vancomycin in patients with periprosthetic joint infections

Aims Although intra-articular vancomycin has demonstrated satisfactory outcomes for periprosthetic joint infection (PJI), dose and dosing frequency remain largely empirical. This study aimed to develop a target-based population pharmacokinetics (PK) model to predict local vancomy...

Phage as a prospective arsenal against superbugs

The escalating crisis of antimicrobial resistance (AMR) necessitates the urgent development of alternatives to traditional antibiotics. Bacteriophage (phage) therapy, which utilizes viruses that specifically infect and lyse bacteria, has re-emerged as a promising therapeutic stra...

A molecular glue induces aberrant STING oligomerization and inhibits autoinflammatory diseases

Dysregulated activation of the stimulator of interferon genes (STING) pathway underlies various inflammatory and autoimmune pathologies. Since STING oligomerization is fundamental to its biological function, targeted modulation of this polymerization process presents a promising...

Preoperative triglyceride–glucose index and 30-day surgical site infection in OSCC patients without documented diabetes: a retrospective cohort study

Surgical site infection (SSI) remains an important complication after oral squamous cell carcinoma (OSCC) surgery. Although diabetes is a recognized infection risk factor, metabolic vulnerability in patients without documented diabetes is less understood. The triglyceride–glucose...

Risk factors and a perioperative prediction model for postreperfusion syndrome in donation after circulatory death liver transplantation: a retrospective cohort study

Postreperfusion syndrome (PRS) is a common and clinically important complication during liver transplantation. It is characterized by marked hemodynamic instability after graft reperfusion and has been associated with adverse perioperative outcomes. However, perioperative factors...