Nanjing Agricultural University

Machine learning reveals divergent drivers and migrating thresholds of cropland degradation in Southern and Northern China

Under the dual pressures of rapid urbanization and climate change, cropland systems in China are facing escalating degradation risks, posing a critical threat to national food security. However, the compound driving mechanisms and nonlinear threshold effects underlying cropland d...

Leveraging Electroosmosis in OmpF for Robust Peptide Sensing

Abstract Peptide sensing and sequencing are essential for elucidating sequence-function relationships and evaluating the peptide drug quality. Nanopore electrochemistry enables label-free characterization of peptide composition, structure, and interactions at the single-molecule...

Lycopene: a review of functional properties, extraction and application in meat field

Lycopene is a natural bioactive compound and has garnered increasing research attention due to its potential benefits for human health. To facilitate the lycopene utilization in the food industry, the present review provides a comprehensive summary of lycopene. Firstly, it elabor...

Chiral Blue-Light Excited Hybrid Copper Iodides with Circularly Polarized Luminescence for Lighting and X-ray Imaging

Abstract Chiral hybrid Cu(I) halides combine outstanding optoelectronic properties with structural chirality, making them promising materials for diverse applications. However, the use of chiral hybrid copper(I) halides for lighting and X-ray scintillators remains largely unexplo...

Hijacking host RNA polymerase for processive in situ mutagenesis

Targeted mutagenesis is a crucial tool for in vivo continuous evolution. However, existing methods for long-range targeted mutagenesis in vivo often face limitations such as low efficiency, poor host compatibility, operational complexity, and uneven distribution of mutations acro...

LncFENIX restricts influenza A virus replication by impairing PDIA3-mediated oxidative folding of hemagglutinin

Influenza A virus (IAV) relies on host endoplasmic reticulum (ER) homeostasis machinery to support the oxidative folding and maturation of viral glycoproteins. Although long non-coding RNAs (lncRNAs) are increasingly recognized as critical regulators of host-virus interactions, w...

A novel positive feedback regulatory loop, TGF-β1/SMAD4/miR-184, controls the follicular development in sows.

transcription by binding to its promoter and forming an RNA-induced transcriptional activation complex with AGO2, CTR9, DHX9, and RNA polymerase II. Consequently, a novel positive feedback loop (TGF-β1/SMAD4/miR-184) was identified. In vitro GC and follicle culture systems valida...

Nanoparticle-Agminated Copper Nanospheres Featuring Tailored Grain Boundary Densities for Enhanced Ammonia Electrosynthesis

Abstract The electrochemical nitrate reduction reaction (NITRR) represents a high-potential avenue for the sustainable synthesis of ammonia (NH3) and for helping to maintain the balance of the nitrogen cycle. Nevertheless, the quest for highly efficient electrocatalysts continues...

Novel Coumarin Derivatives Containing Oxazole/Isoxazole/Pyrazole Groups as Antifungal Agents: Design, Synthesis, Quantitative Structure–Activity Relationships, and Preliminary Mechanistic Insights

Abstract Plant pathogenic fungi pose a significant threat to global crop productivity and food security. Herein, we report the design and synthesis of 55 coumarin–oxazole, −isoxazole, and −pyrazole hybrids as novel antifungal agents. Most derivatives exhibited notable potency, wi...

Small extracellular vesicle-mediated epithelial–macrophage crosstalk contributes to macrophage dysfunction during PEDV infection

Abstract Mucosal immune defense depends on coordinated communication between epithelial and immune cells, yet pathogens can disrupt this crosstalk through diverse mechanisms. Here we show that porcine epidemic diarrhea virus (PEDV), an enteric alphacoronavirus, reshapes epithelia...

Skeletal Distortion Manipulation in 2D–3D-Fused Boron Clusters Enables Solid-State Luminescence and Photothermal Conversion

Abstract Luminescent π-conjugated materials are central to modern optoelectronics, yet they are typically constructed from planar, rigid molecular frameworks. Herein, we introduce a conceptually distinct luminescent molecular platform based on three-dimensional (3D) boron cluster...

Porcine Sertoli cell exosomes tune the redox setpoint of spermatogonial stem cells through PSMD11–p38 MAPK signaling to mediate differentiation

Spermatogonial stem cell (SSC) fate—the choice between self-renewal and differentiation—is governed by intercellular signaling within the testicular niche. A central paradigm holds that endogenous reactive oxygen species (ROS) sustain SSC self-renewal through MAPK signaling. Yet...

Giant Ferroelectric Domain Wall Conductance in MoS2/PbTiO3 Heterostructure for High-Density Memory

Abstract Domain wall (DW) electronics hold promise for high-density computing, but their implementation is limited by low read currents and high operating voltages in bulk ferroelectric oxides. Here, we present a monolayer molybdenum disulfide (MoS2)/PbTiO3 (PTO) van der Waals (v...

Reactive Oxygen Species Formation in Paddy Soils under Alternating Redox Conditions: An Iron-Microbe Synergy Driving Mechanism and Environmental Impacts

Abstract Alternating wetting and drying cycles in paddy soils drive active biogeochemical processes and profoundly influence pollutant migration and transformation. This study systematically investigates the formation and mechanisms of reactive oxygen species (ROS) under anaerobi...

Toward scalable organ-level 3D plant segmentation: A systematic and quantitative review through the lens of the data-algorithm-computing triangle

The precise characterization of plant morphology provides valuable insights into plant-environment interactions and genetic evolution. A key technology for extracting this information is 3D segmentation, which delineates individual plant organs from complex point clouds. Despite...

Enhanced eugenol biosynthesis through GmEGS overexpression confers broad‐spectrum pathogen protection in soybean

Soybean is a major source of plant protein and oil, yet its production is severely constrained by diverse pathogen infections. Here, we identify eugenol as a pathogen-induced defense metabolite in soybean with broad-spectrum antimicrobial activity against fungal, oomycete, and ba...

Baseline Cortisol and Behavioral Phenotype Are Linked to Context‐Dependent Spatial Cognition and Space Use in Giant Pandas

Animals differ consistently in how they respond to novelty and environmental change, but whether such variation links endocrine state, spatial cognition, and space use remains unresolved. In giant pandas (Ailuropoda melanoleuca), we combined novel object tests, a resource-change...

Chemically Initiated Single-Module Afterglow Imaging via Lesion-Microenvironment-Activated Cyanine–Fe Coordination

Abstract Afterglow luminescence imaging offers high sensitivity, deep-tissue readability, and persistent emission for image-guided surgery, but most current probes still require external energy activation, limiting autonomous lesion reporting and increasing the risk of off-target...

Apocynin as a Novel Natural Photosystem II Inhibitor: Target Identification and Structure-Based Design of Potent Herbicidal Derivatives

Abstract Natural products are an important source of lead compounds for novel pesticide discovery. In this study, we investigated the phytotoxicity and mode of action of the phenolic natural product apocynin. Chlorophyll fluorescence analysis indicated that apocynin induces leaf...

Reducing antibiotics? experimental evidence from poultry farmers in China

Antibiotic overuse in the livestock sector has negative environmental implications and leads to bacterial resistance. We set up a randomized controlled trial in two locations in China among poultry farmers to evaluate the effects of a two-pronged approach: Providing micro- subsid...