Nanfang Hospital

Targeted microglial ROS-scavenging alleviates neuroinflammation and cognitive deficits via restoration of the 2-AG/CB2R signaling axis in schizophrenia

Cognitive impairment in schizophrenia is inadequately treated. The molecular link between oxidative stress and neuroinflammation in its pathophysiology remains unclear. We measured CB2R in circulating microglia‑derived exosomes from schizophrenia patients and healthy controls. In...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Innovation Mechanism and Implementation Path of Digital Empowerment for Green Development in High-End Manufacturing Enterprises

In the context of the global green development wave and the rapid iteration of digital technology, digital empowerment has become the core driving force for high-end manufacturing enterprises to achieve green transformation. At present, China’s manufacturing industry is facing th...

Multimodal nanomedicine for precision colorectal cancer management: integrated diagnosis, targeted therapy, and personalized theranostics

Colorectal cancer (CRC) imposes a substantial health burden because of its high incidence and mortality. Despite advances in surgical procedures, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, the overall efficacy is still unsatisfactory, especially for advanced...

Adolescent environmental enrichment prevents early-life stress-induced schizophrenia-like phenotypes via restoration of CREB-BDNF-TrkB signaling

Early-life stress (ELS) is a major environmental risk factor for schizophrenia, yet effective preventive strategies targeting its neurodevelopmental consequences remain limited. Here, we show that adolescent environmental enrichment (EE) prevents the emergence of schizophrenia-li...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Association between high triglyceride-glucose index status and one-year all-cause mortality in patients with thoracic aortic aneurysm: a MIMIC-IV cohort study

The triglyceride-glucose (TyG) index is widely used as a surrogate marker of insulin resistance and has been associated with a range of adverse cardiovascular outcomes. However, its role in the longer-term prognosis of patients with thoracic aortic aneurysm (TAA), particularly on...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

Intermittent fasting promotes plaque regression and activates the BMAL1–MERTK efferocytosis axis

Abstract Background Atherosclerotic cardiovascular disease can progress despite intensive lipid lowering, highlighting the need to identify local mechanisms that remodel established plaques. Intermittent fasting may engage metabolic, circadian, and immune pathways relevant to thi...

Clinical assessment and management of bone health in non-metastatic breast cancer patients: a best practice implementation project

INTRODUCTION: Non-metastatic breast cancer survivors are at higher risk of developing musculoskeletal diseases, including bone metastases, bone loss, pain, osteoporosis, and fractures. Bone health issues may affect patients' quality of life and even reduce survival. Effective ass...

Yield-point detection can improve the mechanical performance of cancellous bone screws

Appropriate torque applied to screws is an insurance for strong and durable fracture fixation. We compared the mechanical characteristics of four types of bone screws during insertion to facilitate the development of an optimal screw torquing strategy. Bone screws were inserted i...

A personal credit management scheme for consortium blockchains integrating smart contracts and light node mechanisms

The increasing demand for trustworthy and privacy-preserving credit reporting systems has exposed the limitations of both centralized and existing blockchain-based solutions, including scalability bottlenecks, weak privacy protection, and insufficient incentive mechanisms. To add...

RL-Augmented Dual Robust Adaptive Propagated Interval Observer for Actuator and Residual-Framed Sensor Fault Detection and Isolation in Underactuated AUVs

Reliable fault detection and isolation (FDI) for actuators and sensors in underactuated autonomous underwater vehicles (AUVs) is challenging because nonlinear hydrodynamic coupling redistributes fault signatures, and persistent ocean currents can trigger false alarms. This paper...

Psychological Well-Being, Activity Satisfaction, and Perceived Social Support Among Middle-Aged and Older Adults in Intergenerational Participation: An 18-Month Longitudinal Study

Using an observational longitudinal design, this study examined psychological well-being, activity satisfaction, and perceived social support among 91 middle-aged and older adults participating in community-based intergenerational activities in Taiwan. Across eight waves over 18...

Endothelial regulators in the infrapatellar fat pad of osteoarthritis revealed by integrative multi-omics and genetic causal inference

Osteoarthritis (OA) is a multifactorial degenerative joint disease involving multiple joint components, including the infrapatellar fat pad (IFP), whose role in OA pathogenesis remains poorly understood. In this study, we employed an integrative multi-omics strategy to delineate...