Monash University

Defining and Measuring Developmental Regression During Childhood: A Scoping Review

ABSTRACT Developmental regression during childhood is inconsistently defined and measured, resulting in delayed diagnostic discovery and intervention. This study aimed to examine published definitions and measures for developmental regression. A comprehensive search strategy was...

Efficacy of Vitamin C Treatment to Aid the Healing of Foot Ulcers in People With Diabetes: A Randomised, Placebo‐Controlled Double‐Blind Trial: The FOOT‐C Study Protocol

ABSTRACT Introduction Diabetes‐related foot ulceration (DFU) is a serious complication, serving as a leading cause of amputation, disability, hospitalisation and a significant contributor to healthcare costs. Deficiencies in vitamin C and other micronutrients are common in DFU. E...

Associations between metabolic dysfunction–associated steatotic liver disease and physical and mental health–related quality of life in older adults

Metabolic dysfunction–associated steatotic liver disease (MASLD) is a common, often overlooked liver condition. Its impact on quality-of-life in older adults is not well understood. We examined the association between MASLD and physical and mental quality of life in a well-charac...

Accountability without an Oracle: ScholarHound for LLM-Produced Scientific Commitments, and Why Claim-Level Gold Is the Binding Constraint

Scientific language-model systems increasingly retrieve papers and write evidence-backed syntheses, yet their judgments are checked by the same class of models that produced them. We present ScholarHound, an accountability layer separating model-mediated interpretation from autho...

Machine Learning for Residential Energy Data Analytics Enhancing Energy Efficiency and Management: Datasets, Methods, and Applications

Abstract Purpose of Review Residential energy analytics has advanced with increasing availability of energy data, e.g., from smart meters, to provide new insights into consumption behaviors and enhance energy efficiency and management. This review synthesizes public datasets, mac...

Historical Anti-Fascism and Right-Wing Voting in Italy

We study how anti-fascist opposition during Mussolini’s dictatorship affects post-war support for right-wing parties in Italy. We construct a measure of anti-fascism from the universe of recorded opponents, and use newly digitized historical data to resolve simultaneity between t...

Metabolic reprogramming enables transient survival and envelope remodelling in Staphylococcus aureus under dalbavancin treatment

Clinical failure of antibiotic therapy can occur in the absence of measurable resistance, yet the biological basis of this discordance remains poorly understood. Here, we identify a transient survival phenotype that limits dalbavancin efficacy and may contribute to treatment fail...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...

An autoinflammatory CDC42 variant M45L demonstrates the mechanism of pyrin inflammasome activation

CDC42 is an evolutionarily conserved guanosine triphosphatase (GTPase) regulating critical cellular and immune processes. Variants in CDC42 therefore cause a spectrum of developmental phenotypes, including hematological and immunological symptoms. Here, we identify a previously u...

Strain Effectson the Mechanical Properties and GasAdsorption and Diffusion Characteristics of Anthracite

Abstract The coal matrix is subjected to complex strain conditions during exploration. Pore structural evolution, gas adsorption, and diffusion characteristics of high-rank coal matrix under uniaxial compressive and tensile strain conditions are investigated through molecular sim...

Implementing evidence in residential aged care facilities: a longitudinal multi-method evaluation of knowledge broker evolution

Background Knowledge brokers act as intermediaries to bridge evidence-to-practice gaps. Limited evidence describes how the knowledge broker role in health settings evolves over time. This study aimed to (a) examine the evolution of knowledge broker activities over a 12-month impl...

Assessing Vancomycin‐Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry

Staphylococcus aureus strains have emerged with resistance mechanisms that reduce the efficacy of last resort antibiotics and evade the immune system. One strategy to combat antimicrobial resistance is to modulate host immunity to eliminate infections more effectively. This has l...

Precisely Timed On‐Demand Droplet Ejection and Collision in Free Space for Controlled Reaction Initiation

Precise initiation and synchronization of chemical reactions in free space remain major challenges for time-resolved studies in structural biology, chemistry, and materials science. Although modern probes provide femtosecond resolution, experimental access to early reaction dynam...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

The Effect of Using Write‐Zoom for Volume Flow Measurements in Haemodialysis Fistulas

ABSTRACT Introduction Arteriovenous fistulas (AVFs) are crucial for patients undergoing haemodialysis, yet about 25% fail to mature or experience early failure. Ultrasound is key in managing AVFs, with volume flow (Qa) serving as a predictor of maturation. Accurate Qa measurement...

Transferrin-Conjugated Polymeric Nanoparticles via Polymerization-Induced Self-Assembly for Enhanced BBB Transport and Glioblastoma Therapy

Abstract Transferrin-coated nanoparticles show promise in delivering chemotherapeutic drugs across biological barriers for treating glioblastoma multiforme (GBM). Employing a synthetic approach integrating advanced chemistries and bespoke in vitro biological assays, we developed...

Building inclusive learning communities: the collaborative role of parents and school leaders in supporting students with additional needs

Inclusive education is widely endorsed as a policy priority; however, less is known about how school leaders practically enable collaboration with parents to support inclusive schooling. This qualitative study examines how secondary school leaders enact and sustain collaboration...

Institutional complexity and entrepreneurial work in grassroots cultural heritage: Evidence from Hanfu entrepreneurship in China

Abstract Cultural heritage entrepreneurship (CHE) often requires entrepreneurs to reconcile authenticity claims with commercial imperatives. This challenge is especially pronounced in grassroots heritage revivals where heritage meanings are contested and cultural authority is une...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...