Ministry of Health

Comparable tolerability, symptom worsening, and treatment completion rates among different Helicobacter pylori eradication regimens in children

The tolerability of Helicobacter pylori ( H. pylori )eradication regimens in children remains a clinical concern, particularly regarding gastrointestinal adverse effects and treatment discontinuation. The aim of this study was to compare the tolerability of different H. pylori er...

Clinical characteristics and functional determinants of central sensitization in chronic neck myofascial pain syndrome

Background Central sensitization (CS) is a key mechanism in chronic pain, but its relationship with cervical muscle pressure pain thresholds (PPT) and disability in myofascial pain syndrome (MPS) remains unclear. Objective To investigate the clinical characteristics and functiona...

Early mRNA expression of pro-inflammatory cytokines and ADAMTS-5 in an acute ischemia/reperfusion–induced pressure ulcer model, a pilot exploratory animal study

Objectives: This study aimed to determine the messenger ribonucleic acid (mRNA) expression levels of interleukin (IL)-1α, IL-1β, IL-6, IL-17, and A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) -5 in an acute ischemia/reperfusion (I/R)-induced pressure ulc...

Outcomes of Iliac Crest Bone-Block Arthrodesis After Failed First MTP Joint Surgery With Bone Loss

Background: Failed first metatarsophalangeal (MTP) joint surgery with bone loss is a challenging revision problem. This study aimed to evaluate the radiographic and clinical outcomes of iliac crest bone-block arthrodesis in this setting. Methods: This retrospective cohort include...

Residual bone height and implant survival after lateral sinus floor elevation: a continuous-variable analysis with 14-year follow-up

Abstract Objectives: To evaluate the effect of residual bone height (RBH) on implant survival following lateral sinus floor elevation (LSFE), and to assess the influence of sinus membrane perforation and patient-related factors. Materials and Methods A total of 217 implants place...

Prognostic factors after pulmonary metastasectomy for colorectal cancer lung metastasis

Objective: Surgical resection of lung metastases in patients with colorectal cancer (CRC) can provide long-term survival in selected cases. This study aimed to evaluate the prognostic factors affecting survival after pulmonary metastasectomy (PM) performed for lung metastases due...

First-trimester aggregate index of systemic inflammation and adverse pregnancy outcomes in hospitalized women with threatened miscarriage: a single-center retrospective cohort study

Abstract Background Complete blood count-derived inflammatory indices have been associated with miscarriage, but the incremental value of the aggregate index of systemic inflammation (AISI) beyond established indices such as the systemic immune-inflammation index (SII) remains un...

Comparative Evaluation of ChatGPT-5.2, Claude Sonnet 4.5, and DeepSeek for Rosacea-Related Information: Accuracy, Reliability, Readability, and Reference Hallucinations

Background/Objectives: Rosacea is a chronic inflammatory skin disease that requires long-term management and continuous patient education regarding triggers, skincare practices, and treatment adherence. In recent years, patients have increasingly turned to online platforms and ar...

Knowledge, attitude, and practice of antifungal resistance and stewardship among pharmacy students in Zambia: a cross-sectional study to inform antifungal stewardship programs

Background Antifungal resistance (AFR) is a growing global health threat, particularly in low- and middle-income countries such as Zambia, where antifungals are often accessed without prescription. Antifungal stewardship (AFS) programs aim to optimise antifungal use, yet limited...

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Diagnosis, management, and prevention of Crimean-Congo haemorrhagic fever: a Delphi-based consensus study in Türkiye

Background Crimean-Congo haemorrhagic fever (CCHF) is a widely distributed viral haemorrhagic fever with expanding geographic range. As new regions encounter the disease, clinicians must make high-stakes decisions despite limited standardised management frameworks. Methods In thi...

Clinical Outcomes Following Transition from ICS/LABA to Single-Inhaler Triple Therapy in Patients with Uncontrolled Asthma: A Real-World Cohort Study

Background and Objectives: A considerable proportion of patients with asthma remain inadequately controlled despite treatment with inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) therapy. Single-inhaler triple therapy comprising an inhaled corticosteroid, a long-acting β...

NBN rs1805794 Polymorphism Increases the Predictive Performance of Machine Learning Models for Multiple Chronic Toxicities in Head and Neck Cancer Survivors Treated with Definitive Radiotherapy ± Chemotherapy

Objective: While advancements in radiotherapy and systemic agents have significantly improved survival rates in head and neck squamous cell carcinoma (HNSCC), managing long-term, treatment-induced toxicities remains a critical clinical challenge. This study aimed to develop a per...

Mesenteric Hyaline Vascular Castleman Disease Presenting as Acute Mechanical Intestinal Obstruction

The Annali Italiani di Chirurgia (ISSN/eISSN: 0003-469X/2239-253X) is the oldest surgical journal in Italy. It covers all aspects of surgery and its allied disciplines, including elective, emergency and experimental surgery, as well as problems involving technology, teaching, org...

Clinicopathological Features, Tumor Localization and Treatment Outcomes in Paraganglioma: A Single-Center Medical Oncology Cohort

Background/Objectives: Paragangliomas (PGLs) are rare neuroendocrine tumors, and data describing them from a medical oncology perspective are limited. We characterized clinicopathological features, tumor localization, and treatment outcomes. Methods: We retrospectively analyzed 4...

Mentalization and Emotion Regulation Difficulties in Adolescent Girls With Social Anxiety Disorder

INTRODUCTION: Social anxiety disorder (SAD) is a prevalent disorder that often begins during adolescence, leading to considerable challenges in social functioning and overall mental health. Previous studies have demonstrated that mentalization deficits and emotion regulation diff...

Surgical treatment of anal fistula: classic elastic seton application and LIFT method

Anal fistulas remain a challenging problem in colorectal surgery, and the optimal sphincter-preserving technique is still debated. We compared the LIFT procedure and elastic seton application in terms of treatment outcomes, postoperative pain, anal continence, and quality of life...

Asparagine synthetase deficiency: clinical features and experience with asparagine supplementation

Abstract Objectives Asparagine synthetase deficiency is a rare autosomal recessive neurometabolic disorder characterized by congenital and progressive microcephaly, severe developmental delay, epilepsy, and progressive cerebral atrophy. Therapeutic experience with L-asparagine su...

Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study

Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during b...

Integrated serum and synovial biomarker profiling reveals inflammatory and cartilage remodeling signatures in age-restricted knee osteoarthritis

Knee osteoarthritis (OA) is a complex disease characterized by inflammation, cartilage degeneration, and tissue remodeling. Although many biomarkers have been investigated, the combined biological significance of systemic and local biomarkers is not fully understood. This study a...