Melbourne Health

What are people saying about DoxyPEP? A topic-based analysis of Reddit discussions

BACKGROUND: Doxycycline post-exposure prophylaxis (DoxyPEP) is a strategy for bacterial STIs prevention; however, despite strong evidence from clinical trials that DoxyPEP reduces the incidence of syphilis and chlamydia, its real-world uptake is shaped by public perception. In th...

hpci improves reproducibility of computational biology research by integrating Continuous Integration with High Performance Computing clusters

Abstract Motivation The reproducibility crisis in bioinformatics and computational biology can be mitigated by using Continuous Integration (CI), a proven software engineering practice, to automate the testing of analysis pipelines and models. However, the adoption of CI in bioin...

‘Prehabilitation Should Adapt to the Person, not the Other Way Around’: A Qualitative Study Exploring Stakeholder Perceptions of Prehabilitation for Total Hip and Knee Arthroplasty

ABSTRACT Background Prehabilitation aims to increase functional capacity and physiological reserve prior to surgery, to improve post‐operative outcomes. Despite growing research on prehabilitation for total hip arthroplasty (THA) and total knee arthroplasty (TKA), its acceptabili...

Glutamate levels in antipsychotic-free, first-episode psychosis: a 7-tesla MRS study across five brain regions

Disrupted glutamatergic signaling across cortical and subcortical circuits is increasingly recognized as a critical player in the pathophysiology of psychosis. Using ultra-high-field (7 Tesla) proton MRS, we quantified glutamate levels across five brain regions in antipsychotic-f...

Modelling the impact of improving access to healthcare on hepatitis B prevalence in the Thai–Myanmar border region

Abstract In Thailand, hepatitis B remains endemic despite a strong elimination programme. Four neighbouring countries, with higher hepatitis B prevalence, contribute to over 90% of the migrant workforce in Thailand, and 75% migrant workers are from Myanmar. Access to healthcare f...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Diagnostic accuracy of a malaria rapid diagnostic test compared with polymerase chain reaction in Lao People’s Democratic Republic: a secondary data analysis

Abstract Background Malaria rapid diagnostic tests (RDTs) are widely used in malaria endemic countries in both clinical and community settings for timely diagnosis, case management and surveillance. Since Greater Mekong Subregion countries approach malaria elimination with residu...

Exploring Cultural and Individual Differences in the Hierarchy of Moral Concern: Evidence From Student Samples Across 41 Cultural Groups

ABSTRACT Many important historical and contemporary ethical debates (e.g., on slavery, abortion and environmental protection) reflect disagreements about what we owe to different groups of individuals. Recent work in moral psychology has uncovered a seemingly replicable hierarchy...

The National Health and Medical Research Council Research Impact Indicators: Unveiling Omissions and Blind Spots, and Positioning for Change

ABSTRACT Issue Addressed This study assesses how the concept of (health) research impact has been operationalised in National Health and Medical Research Council (NHMRC) Impact Case Studies, and if and how lived experience research priorities have been considered, to ascertain im...

Combining Implementation and Data Sciences to Accelerate Evidence Integration into Healthcare – ImpleMATE

Background The translation of research evidence into routine healthcare practice is often slow and inconsistent, even timely implementation can significantly improve patient outcomes. While implementation science offers strategies to close this gap, current approaches are frequen...

Stroke clinical documentation education program in Australia and New Zealand

Background: Accurate and complete clinical documentation underpins the assignment of International Classification of Disease codes used for epidemiological research, hospital activity based funding, and health service planning. Objective: To develop, implement, and evaluate an ed...

Technology meets time: assessing the impact of clinical decision support tools for viral hepatitis in primary care (the HepLOGIC pilot and feasibility study)

Lack of diagnosis and management of hepatitis B and C in Australia contribute to the increasing burden of liver cancer and other adverse outcomes for those affected. The Hep atitis and l iver cancer o utcomes in g eneral practice: an i ntervention c ollaboration (HepLOGIC) study...

Informing Data-Based Suicide Prevention – Evaluation of the Real-Time Suicide Observatory in Cork and Kerry

The Suicide Observatory in Cork and Kerry was established to address the urgent need for real-time suicide data in Ireland to enable timely suicide prevention. This study aimed to assess the performance and efficiency of the Suicide Observatory to inform decisions about its upsca...

Implementing univerSal TeleprehabiliTation into cAnceR caRe pathwayS (STTARRS Trial): protocol for a hybrid type 1 multi-centre randomised controlled trial and nested sub study

Abstract Background Postoperative complications are common after major cancer surgeries, occurring in 25–50% of patients. They delay recovery and adversely affect both cancer-free and overall survival. Intervention to optimise patients’ physical and psychological wellbeing before...

The association of involvement in clinical activities and job satisfaction among hospital and community pharmacists: an application of Herzberg’s two factor theory

The role of pharmacists in providing clinical activities has been expanded in several countries to address the increasing demand for healthcare services. This paper aims to (1) quantitatively investigate the relationship between job satisfaction and involvement in clinical activi...

The use of natriuretic peptide to screen for stage B heart failure based on echocardiogram among cancer survivors

Abstract Background and Aims Heart failure is a progressive disorder that can be identified at earlier stage, also known as stage B heart failure (SBHF). While N-terminal pro-B-type natriuretic peptide (NT-proBNP) was shown to be a key biomarker, its screening performance among c...

Coronary Plaque Burden and Plaque Composition in Long-Term Cancer Survivors: A Comparative CCTA Study

Abstract Background The increased risk of atherosclerotic cardiovascular disease in cancer survivors is not fully elucidated. Understanding the coronary plaque burden and composition in survivors could address this gap. Objectives To determine whether cancer survivorship is assoc...

Parent and child preferences for a community-based physical activity participation intervention for children born very preterm: a qualitative framework analysis

PURPOSE: Children born very preterm (VP: <32 weeks' gestation) are less physically active than their term-born peers and face greater barriers to participation in community-based activities. This study consults with key knowledge holders (children born VP and their parents) to un...

The effect of augmented protein intake on nitrogen balance: A nested cohort study of the TARGET protein trial

Purpose The impact of augmenting enteral protein delivery on nitrogen balance, urea generation, and kidney function in critically ill patients remains poorly defined. This study aimed to investigate these effects in a nested cohort within the TARGET Protein trial. Methods We cond...

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is mos...