Medical University of Warsaw

Discordance between concern and guideline-defined gestational weight gain status: a multicentre cross-sectional study of pregnant women

Concern about gaining too much weight may not correspond to guideline-defined excessive gestational weight gain (GWG) and may instead reflect body-related experiences. We assessed concordance between concern and excessive GWG and associations of concern, weight-related body estee...

Phthalazine as a medically versatile polyheterocyclic core with underexplored anticancer potential

Phthalazine derivatives are nitrogen-containing heterocyclic compounds that have gained considerable attention in medicinal chemistry due to their pharmacological potential. This review briefly outlines the biological properties and clinical application of five- and six-membered...

Buccal Fat Pad “Shield” Technique in Augmentation of the Midface

The buccal fat pad (BFP) has been established as a valuable material in oral and maxillofacial surgery for the repair of cleft defects, oroantral communications, and coverage of osteonecrotic areas of the jaws. In esthetic surgery, bichectomy is a procedure that aims at BFP remov...

The Role and Assessment of Lipid Profile in Patients With a Chronic Total Coronary Occlusion

ABSTRACT Adequate lipid management is a crucial component in the treatment of chronic coronary syndromes, a group of conditions that also encompasses patients with chronic total coronary occlusions (CTOs). Importantly, atherosclerotic progression may be especially rapid in patien...

Cyclodextrin Interactions with Water-Soluble Vitamins: Biological Relevance, Stability, Delivery, and Translational Implications—A Critical Review

Water-soluble vitamins participate in essential metabolic, redox, and coenzyme-dependent processes, yet their effective delivery can be limited by chemical instability, degradation during processing or storage, restricted membrane transport, and formulation-dependent loss of biol...

Gigavoxel-scale multiple-scattering-aware lensless holotomography

Abstract Holotomography (HT) has revolutionized quantitative label-free 3D imaging, yet conventional lens-based implementations are fundamentally constrained in field-of-view (FOV) and imaging depth, limiting their utility for critical high-throughput applications in material and...

Targeting C4d to overcome resistance to antibody-based immunotherapy: an in vitro study

Tumor cells often develop defense mechanisms that render them insensitive to consecutive administrations of therapeutic monoclonal antibodies. This study aimed to produce an antibody that preferentially binds resistant tumor cells and eliminates them by the complement system atta...

Quality of life, caregiver burden, and clinical correlates in Kabuki syndrome: a cross-sectional observational study

Kabuki syndrome (KS) is a rare multisystem neurodevelopmental disorder caused by pathogenic variants in KMT2D or KDM6A . We examine quality of life (QoL), its correlates, patterns of rehabilitation utilization, patient functioning, and caregiver burden in a Polish patient group....

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

Longitudinal Changes in QTc Interval in Cancer Patients After the Initiation of Systemic Therapy: Analysis of the ONCOECHO Study Cohort

Background/Objectives: Anticancer therapies are associated with a prolongation of QT interval of electrocardiogram (ECG), increasing the risk of arrhythmias. To evaluate this risk in cardiovascular disease-free subjects with cancer, ECG recorded at baseline, months 3, 6 and 12 fr...

Anti-NMDA Receptor Encephalitis Associated with Ovarian Teratoma: A Comprehensive Review

Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR-E) is a severe autoimmune encephalitis that predominantly affects young women and is frequently associated with ovarian teratomas. Increasing evidence indicates that these tumors play a central role in disease initiation...

Medical Image Texture: Biological Phenotype or Technical Fingerprint? From Early Texture Analysis to Radiomics and Clinical Decision-Making

Gotowe do wklejenia w pole Description. Edytor Zenodo obsługuje formatowanie, więc pogrubienia i akapity przeniosą się poprawnie. Preprint of a narrative review. Medical images have long been interpreted using qualitative descriptors of spatial organization such as homogeneity, h...

Synthesis and biological evaluation of novel dicarboximide-aryl/heteroarylpiperazine hybrid derivatives as anticancer agents

Dicarboximide derivatives and piperazine-containing compounds have independently demonstrated promising anticancer properties; however, limited studies explored the biological potential of their hybridization. In the present study, six novel aryl- and heteroarylpiperazine derivat...

Medical Image Texture: Biological Phenotype or Technical Fingerprint? From Early Texture Analysis to Radiomics and Clinical Decision-Making

Gotowe do wklejenia w pole Description. Edytor Zenodo obsługuje formatowanie, więc pogrubienia i akapity przeniosą się poprawnie. Preprint of a narrative review. Medical images have long been interpreted using qualitative descriptors of spatial organization such as homogeneity, h...

Leveraging Synthetic Clinical Data for Validation and Operational Readiness in Clinical Trials

Background/Objectives: Obtaining timely access to detailed clinical trial data is not always straightforward. Privacy requirements, governance processes, and study-specific eCRF configurations can delay access, particularly during study start-up, when teams need realistic data to...

Myalgic encephalomyelitis/chronic fatigue syndrome and overlapping post-acute infection syndromes: international expert consensus framework for diagnostic standardization

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) lacks validated objective diagnostic criteria, leading to delayed diagnosis and inconsistent management. We aimed to establish an international expert consensus framework integrating measurable, risk-stratified assessmen...

Ferroptosis at the tumor–immune interface: seeking a middle ground between tumor eradication and T-cell fitness

Abstract Background Ferroptosis is an iron-dependent form of regulated cell death, which is manifested by the lethal accumulation of lipid peroxides. While it is considered a promising strategy for the elimination of apoptosis-resistant cancer cells, growing evidence highlights t...

Hepatic Steatosis in Pulsed Field Ablation for Atrial Fibrillation: Prevalence, Liver Marker Concordance and Acute Procedural Characteristics

Background/Objectives: Hepatic steatosis and metabolic dysfunction-associated steatotic liver disease (MASLD) are cardiometabolic phenotypes relevant to atrial fibrillation (AF), but their prevalence and acute procedural relevance in pulsed field ablation (PFA) are poorly defined...

Exploring birth options after three or four cesarean sections in Poland: maternal and neonatal outcomes following vaginal vs repeat surgical deliveries

OBJECTIVES: Postpartum depression (PPD) profoundly affects maternal health and disrupts mother-infant bonding, with lasting effects on infant development. The causal roles of hormones that change most dramatically during the perinatal period, including estradiol, cortisol, and pr...

Clinical characteristics associated with failure to achieve a prespecified guideline-directed medical therapy target at discharge in patients with HFrEF undergoing scheduled hospitalization: a secondary analysis of the HEROES study

Abstract Guideline-directed medical therapy (GDMT) is crucial for the pharmacological management of heart failure (HF) with reduced ejection fraction (HFrEF). The aim of the study was to identify clinical characteristics associated with failure to achieve the prespecified stringe...