Medical University of Warsaw

Symptom duration and postoperative outcomes in degenerative cervical myelopathy: a systematic review and meta-analysis

Abstract Background: Surgical decompression is regarded as standard treatment for degenerative cervical myelopathy (DCM). However, the timing of surgery remains a critical yet unresolved issue in clinical practice. Therefore, this meta-analysis aimed to evaluate the impact of sym...

Advanced airway management practice patterns and short-term survival in Poland’s national physician-staffed helicopter emergency medical service, 2020–2024: a retrospective observational study

Advanced prehospital airway management involves endotracheal intubation or supraglottic airway placement. Evidence on airway management and survival in combined ground EMS–HEMS care remains limited, particularly regarding technique sequence and outcomes across clinical groups. Th...

Pain Coping Strategies Among Adult Patients with Degenerative Disc Disease

Background/Objectives: This cross-sectional observational study aimed to investigate how individuals with lumbar degenerative disc disease (DDD) cope with pain and its association with their affective state, especially in relation to the symptoms of anxiety and depression. The st...

Bedside analysis of volatile organic compounds in exhaled human breath as non-invasive diagnostic tool for colon diseases

Background Measurements of volatile organic compounds (VOCs) in exhaled air represent a promising noninvasive biomarker modality for gastrointestinal diseases and has potential to enable point-of-care diagnostics.Aim To evaluate the feasibility of differential ion mobility spectr...

Renoprotective vs. Antihypertensive Dosing of Renin–Angiotensin System Inhibitors in Chronic Kidney Disease: Analysis of Summary of Product Characteristics of Medicinal Products Authorized in Poland

Introduction: Renin–angiotensin system inhibitors are central to antihypertensive and nephroprotective treatment in chronic kidney disease. However, renal dosing information in Summaries of Product Characteristics (SmPCs) may differ between products and may not reflect current ki...

Manganese-Enhanced Magnetic Resonance Imaging: From Translational Research to First-in-Human Trials in Oncology

Manganese-enhanced magnetic resonance imaging (MEMRI) is a functional imaging technique with several potential applications in various research fields. Manganese-enhanced magnetic resonance imaging uses paramagnetic manganese (II) ions (Mn 2+ ) as the contrast enhancer, as they a...

Disease- and Region-Specific Molecular Patterns Involving miRNAs and Associated Signalling Pathways and Epithelial Cell-Fate Responses in PSC-Associated Ulcerative Colitis

Patients with primary sclerosing cholangitis-associated ulcerative colitis (PSC-UC) have an elevated risk of colorectal cancer compared with ulcerative colitis (UC), but the molecular mechanisms linking chronic inflammation to epithelial cell fate remain unclear. The present stud...

Trends in Hospitalizations of Patients with Idiopathic Inflammatory Myopathies: Long-Term Observational Study, 2010–2024

Background/Objectives: Idiopathic inflammatory myopathies (IIMs) are very rare, chronic, immune-mediated diseases that clinically manifest with myositis symptoms and extramuscular manifestations. The rarity of the disease makes it difficult to conduct double-blind studies, and la...

Synthesis of colloidal silver-polyphenols nanocomplexes - physicochemical properties, DFT calculation, modeling of adsorption and antibacterial activity

Abstract The aim of the studies was the investigation of nanocomplexes based on a silver core and attached three polyphenolic compounds belonging to tannins i.e. tannic acid (AgNPs-TA), 3,6-bis- O -di- O -galloyl-1,2,4-tri- O -galloyl- β -D-glucose (AgNPs-RT) and 1,2,3,4,6-penta-...

Limitations of Fried frailty criteria in kidney transplant recipients with arteriovenous fistulas

Background: Kidney transplant recipients (KTRs) are prone to development of muscle dysfunction and frailty. This study aimed to assess muscle strength and body composition alterations in KTRs, and whether an arteriovenous fistula (AVF) can influence handgrip strength (HGS) result...

Pharmacological targeting of ferroptosis in cancer: mechanisms, tumor immunity, and translational challenges

Abstract Ferroptosis is an iron-dependent form of regulated cell death driven by phospholipid peroxidation and the failure of cellular antioxidant defenses. Its close integration with iron metabolism, lipid remodeling, and redox homeostasis has identified ferroptosis as a potenti...

Gene-Corrected Human iPSC–Derived Cardiomyocytes and Skeletal Muscles Reveal Partial Dystrophin Dp427 Preservation and Cardiac Dp116 Expression in Duchenne Muscular Dystrophy Patient With a Splice-Site Mutation in Intron 68 (c.9975-1G>T)

BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disease caused by mutations in the DMD gene, leading to the absence or dysfunction of dystrophin. Although cardiac and skeletal muscles are both affected, tissue-specific differences in disease manif...

C3- and C5-deficient murine cells exhibit severe mitochondrial defects, indicating a pivotal, novel role of innate immunity in regulating hematopoiesis at the electron transfer chain level

We recently reported that the functional intracellular complement network, known as the complosome, is expressed in hematopoietic stem/progenitor cells (HSPCs). In our recent work, murine lineage-negative (Lin − ) bone marrow (BM) mononuclear cells (BMMNC) from C3-KO and C5 –/– m...

Asparagine Synthetase Deficiency: A Novel ASNS Variant and a Systematic Review of Clinical Phenotypes and Cerebrospinal Fluid Asparagine Levels

Background: Asparagine synthetase deficiency (ASNSD) is a rare autosomal recessive neurometabolic disorder associated with microcephaly, severe developmental impairment, epilepsy, and progressive cerebral atrophy. Reduced cerebrospinal fluid (CSF) asparagine has been proposed as...

Long-term Results of Allogeneic Hematopoietic Cell Transplantation (allo-HCT): Real-life Data of 15- and 20-year Survivals from a Single Center

Allogeneic hematopoietic cell transplantations (allo-HCT) is a procedure with long history and well-documented efficacy in treating various malignant and non-malignant diseases of the hematopoietic system. While there is a potential for late complications even over 10 years follo...

DENTAL MISINFORMATION ON SOCIAL MEDIA: CONTENT QUALITY, USER ENGAGEMENT, AND IMPLICATIONS FOR ORAL HEALTH LITERACY – A NARRATIVE REVIEW

Objectives: This narrative review aimed to summarize current evidence on dental misinformation on social media, with a particular focus on content quality, user engagement, and possible implications for oral health literacy and patient decision-making. Methods: A narrative litera...

Line‐Field Confocal Optical Coherence Tomography: A Diagnostic Tool Facilitating the Diagnosis of Sweet's Syndrome. A Case Report

ABSTRACT Sweet's syndrome is a rare neutrophilic dermatosis characterized by an acute onset of erythematous and infiltrative lesions. Diagnosis is based on clinical, histopathological, and laboratory findings. We propose that non‐invasive skin imaging techniques, such as line‐fie...

MicroRNA-122 as a regulator and biomarker of liver disease

MicroRNA-122 (miR-122) is the most abundant liver-specific microRNA, comprising ~ 70% of the hepatic miRNA pool, and a central regulator of lipid metabolism, inflammation, fibrosis, viral replication, and hepatocarcinogenesis. This review synthesizes experimental, clinical, and m...

Mapping the lingual artery: a scoping review and proposed imaging-informed risk classification for surgical and radiological practice

The lingual artery (LA) shows significant morphological and topographical variation that can affect the safety and results of head and neck surgeries, carotid interventions, and free flap reconstructions. Traditional descriptions such as the thyrolingual trunk (TLT), linguofacial...

Phthalazine as a medically versatile polyheterocyclic core with underexplored anticancer potential

Phthalazine derivatives are nitrogen-containing heterocyclic compounds that have gained considerable attention in medicinal chemistry due to their pharmacological potential. This review briefly outlines the biological properties and clinical application of five- and six-membered...