Medical University of Sofia

Digital Technologies in Undergraduate Dental Education: A Scoping Review

Digital technologies are becoming increasingly embedded in undergraduate dental curricula, with the potential to support learning and skills development. This scoping review mapped recent evidence on the implementation and educational applications of contemporary digital technolo...

2-Propyl-1-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)pentan-1-one

A new hybrid molecule, combining the pharmacologically relevant scaffolds of valproic acid and trimetazidine, is reported. The target compound was synthesized via a rapid mechanochemical approach using a planetary ball mill, enabling the efficient coupling of the branched-chain v...

Prevalence of metabolic syndrome among patients with Alzheimer disease

Background: The relationship between metabolic syndrome (MetS) and Alzheimer disease (AD) has gained increasing attention in recent years, reflecting the growing recognition of metabolic factors in neurodegenerative conditions. The present study aims to estimate the prevalence of...

Management of Type 2 Diabetes, 2026. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the consensus statement on the management of type 2 diabetes in nonpregnant adults, published since 2006 and last updated in 2022. The target audience is the multid...

Patterns of Endometrial Immune Remodeling Following Intrauterine Platelet-Rich Plasma Administration Are Associated with Baseline Macrophage Abundance

Platelet-rich plasma (PRP) has emerged as a regenerative therapy for improving endometrial receptivity, although its effects on the endometrial immune microenvironment remain poorly understood. This prospective paired-sample study investigated changes in the endometrial immune mi...

Conversational Agent-Based CBT Intervention for Anxiety and Depression in Medical Students: A Pilot Randomized Feasibility Study

Background: Medical students experience substantially higher rates of anxiety and depressive symptoms than similarly aged members of the general population. Academic, financial, and social pressures, together with concerns about stigma, may discourage timely engagement with conve...

Beyond Ejection Fraction: Inflammatory Risk and Mortality in Heart Failure

Background: Inflammation is increasingly recognized as an important contributor to the progression of heart failure and may partly explain differences in prognosis beyond conventional clinical characteristics. Simple laboratory-based inflammatory indices may offer additional prog...

Mapping the lingual artery: a scoping review and proposed imaging-informed risk classification for surgical and radiological practice

The lingual artery (LA) shows significant morphological and topographical variation that can affect the safety and results of head and neck surgeries, carotid interventions, and free flap reconstructions. Traditional descriptions such as the thyrolingual trunk (TLT), linguofacial...

Current clinical applications and future developments of platinum-based anticancer drugs

The study evaluated the current patterns of guideline-recommended clinical use, real-world utilization trends, and translational development of platinum-based (Pt-based) drugs through a comparative analysis of national and international pharmacotherapeutic guidelines, national dr...

Limb-Sparing Resection with Prophylactic Tibial Fixation and Medial Gastrocnemius Flap Reconstruction for Recurrent Leiomyosarcoma in a Previously Irradiated Leg: A Case Report

Background and Clinical Significance: Local recurrence of extremity leiomyosarcoma after multiple operations and radiotherapy presents a major therapeutic challenge. Adequate oncologic clearance must be balanced against preservation of skeletal stability and reliable wound covera...

Uric acid as an integrative severity marker in hospitalized patients with heart failure: association with NT-proBNP, inflammation and renal dysfunction

Serum uric acid (UA) is a routinely measured laboratory parameter, and elevated levels have been associated with adverse cardiovascular outcomes. However, its prognostic role in hospitalized patients with heart failure remains insufficiently clarified. The aim of this study was t...

Tips and Tricks for Small Molecule and Force Field Parametrization

In order to be productive in drug design and materials science, molecular dynamics force fields need to possess quality and fidelity that allow researchers to observe phenomena in simulation before observing them in experiment. The inverse scenario parameters and force fields tha...

MolecularStriptease of a Thiadiazolopyrimidine HitYields a Streamlined, Artifact-Free NADPH Mimic for NOX Inhibition

Abstract The convergence of oxidative stress and inflammation drives neurodegeneration and cancer, positioning NADPH oxidases (NOXs) as critical therapeutic targets. Starting from the polyfunctional thiadiazolopyrimidine hit 1, we systematically truncated its peripheral arms to m...

Micro-CT Assessment of Dentin Mineral Density and Furcation Morphology in Primary First and Second Molars

Background/Objectives: The furcation region of primary molars is a critical anatomical zone with high clinical relevance in endodontics and restorative dentistry due to its proximity to the pulp chamber and potential accessory canal communications. This study aimed to quantitativ...