Medical University of Lodz

Celastrol and Its Derivatives in Breast, Ovarian, and Cervical Cancer: Molecular Targets, Signalling Networks, and Nanocarrier-Based Delivery

Celastrol, a quinone methide pentacyclic triterpenoid obtained mainly from the roots of Tripterygium wilfordii Hook. f., forms covalent, often reversible, adducts with cysteine thiols in regulatory proteins, which underlies its multi-targeted action. This review summarises the pr...

Empirical Antibiotic Initiation for Suspected Early-Onset Neonatal Infection in the Setting of Maternal GBS Screening and Intrapartum Antibiotic Prophylaxis: A Single-Center Retrospective Cohort Study

Background and Objectives: Maternal Group B Streptococcus (GBS) screening and intrapartum antibiotic prophylaxis have reduced early-onset GBS disease. However, suspected early-onset neonatal infection (EONI) remains a broader clinical challenge, as signs prompting empirical antib...

Emergency abdominal surgery: variation in closure practice and early postoperative outcomes in the prospective multicentre PROPHECY study

Emergency abdominal surgery carries a high risk of postoperative morbidity, yet prospective multicentre data on real-world abdominal wall closure practices remain limited. This interim analysis of the PROPHECY study aimed primarily to characterise current abdominal wall managemen...

In vitro evaluation of pH, calcium ion release and interfacial characterization of calcium silicate–based and epoxy resin–based sealers

Abstract This in vitro study evaluated the physicochemical properties and interfacial behavior of four calcium silicate–based sealers (CSBS) compared to an epoxy resin–based sealer. Specimens were prepared under standardized conditions, and pH and calcium (Ca 2+ ) ion release wer...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

Diagnostic Accuracy of Amino Acid PET for Differentiating Tumor Recurrence or Progression from Treatment-Related Changes in Glioma Patients: A Uppstematic Review and Meta-Analysis

Background: Differentiating tumor recurrence from treatment-related changes in patients with glioma remains a major diagnostic challenge because conventional MRI has limited specificity. Amino acid positron emission tomography (PET) has emerged as a promising adjunctive imaging m...

Tobacco and nicotine product use patterns among young healthcare professionals in Poland: findings from the qualitative component of the NIKO Study

While healthcare professionals (HCPs) are in many ways the best-positioned promoters of smoking cessation, many of them use tobacco and nicotine products (TNPs), which can undermine their credibility. In this paper, we report a qualitative study undertaken to assess TNPs’ use pat...

SYSTEMIC ISOTRETINOIN AND ORAL HEALTH: SALIVARY, MUCOSAL, AND PERIODONTAL CHANGES AND IMPLICATIONS FOR DENTAL PRACTICE

Systemic isotretinoin is widely used for the treatment of severe acne and is frequently associated with mucocutaneous adverse effects. Oral manifestations may include xerostomia, reduced salivary flow, cheilitis, mucosal discomfort, and changes in periodontal parameters, but thei...

Outcomes and adverse events of postoperative stereotactic interventional radiotherapy/brachytherapy for brain metastases: a systematic review

Postoperative radiotherapy is commonly used after resection of brain metastases, but durable local control with a low rate of adverse events (AEs) remains challenging. This systematic review summarizes outcomes and AEs of postoperative stereotactic interventional radiotherapy (S-...

Greenwashing and Trust in Sustainable Food Systems: A Systematic Review and Research Agenda

ABSTRACT The global transition toward sustainable food systems has increased the importance of environmental claims in shaping consumption patterns and sustainability outcomes. Trust is essential for enabling sustainable food system transitions; however, greenwashing undermines c...

Impact of Photodynamic Therapy on Mast Cell-Associated Inflammation and Angiogenesis in Actinic Keratosis

Background/Objectives: Actinic keratosis (AK) is a common ultraviolet-induced intraepidermal neoplasm with a recognized potential to progress to cutaneous squamous cell carcinoma (cSCC). Although photodynamic therapy (PDT) is an established field-directed treatment for AK, its ef...

Alternative tobacco and nicotine products during anticancer therapy: a systematic review of mechanistic toxicology evidence, treatment-resistance signals, and potential hazards

The aim of this review is to determine the effect of alternative tobacco/nicotine products on response to chemotherapy, including mechanistic toxicology evidence, treatment-resistance signals and potential hazard. The literature was searched in PubMed, Embase and Web of Science d...

Longitudinal Changes in QTc Interval in Cancer Patients After the Initiation of Systemic Therapy: Analysis of the ONCOECHO Study Cohort

Background/Objectives: Anticancer therapies are associated with a prolongation of QT interval of electrocardiogram (ECG), increasing the risk of arrhythmias. To evaluate this risk in cardiovascular disease-free subjects with cancer, ECG recorded at baseline, months 3, 6 and 12 fr...

Home-based simeox therapy and respiratory symptoms in Non-CF bronchiectasis: a randomized pilot study

Abstract Airway clearance is a cornerstone of management in non–cystic fibrosis bronchiectasis (NCFB), a chronic condition characterized by airway inflammation, mucus hypersecretion, and impaired mucociliary clearance, leading to recurrent infections and progressive lung function...

Prognostic Factors of Mortality and Clinical Characteristics of Patients Surgically Treated for Blunt Liver Injury—A Single-Center Experience

Background: Blunt liver traumatic injuries are associated with high mortality and remain a significant challenge for modern healthcare systems. The aim of this study was to identify early clinical predictors of mortality in patients undergoing surgery for blunt liver injury. Mate...

Clinical characteristics associated with failure to achieve a prespecified guideline-directed medical therapy target at discharge in patients with HFrEF undergoing scheduled hospitalization: a secondary analysis of the HEROES study

Abstract Guideline-directed medical therapy (GDMT) is crucial for the pharmacological management of heart failure (HF) with reduced ejection fraction (HFrEF). The aim of the study was to identify clinical characteristics associated with failure to achieve the prespecified stringe...

Severity of Reactions in Double-Blind Placebo-Controlled Food Challenges: New Insights From the EuroPrevall Outpatient Clinic Study

BACKGROUND AND OBJECTIVES: Oral food challenge, particularly double-blind placebo-controlled food challenge (DBPCFC), is the gold standard for diagnosis of food allergy, although safety concerns limit its widespread use. Objectives: To evaluate the severity of reactions during DB...

Familial Co‐Aggregation of Neurodevelopmental Conditions and Childhood‐Onset Type 1 Diabetes

ABSTRACT Aim Childhood‐onset Type 1 diabetes (T1D) is associated with neurodevelopmental conditions (NDCs). We examined whether this association extends to relatives and assessed phenotypic, genetic, and environmental correlations between T1D and NDCs. Methods Using Swedish regis...

Recommendations of Multiple Sclerosis and Neuroimmunology Section of the Polish Neurological Society and the Polish Society of Gynecologists and Obstetricians for family planning and pregnancy management in women with multiple sclerosis: an update

INTRODUCTION: Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the Central Nervous System that most commonly affects females of reproductive age. Therefore, the issue of family planning is relevant in this population, especially in the context of starting a...

General Assessment of Indole Derivatives and Wnt Pathway as Potential Key Factors Against Various Diseases, with Particular Emphasis on Thyroid Tumors

Indoles are chemical compounds that naturally occur in Prokaryotes and Eukaryotes. For example, indole alkaloids mainly occur in plant families such as Nyssaceae, Rubiaceae, Apocynaceae, and Loganiaceae. The popularity of indoles has led to further research into their function an...