Mashhad University of Medical Sciences

The dietary inflammatory index and its associations with sleep, mental health, quality of life and aggressive behavior in Iranian female adolescents

The relationship between the inflammatory potential of foods and sleep, mental health, quality of life and aggressive behaviors is not well understood in Iranian female adolescents. We aimed to address this since there is a high prevalence of these factors in this population. In...

Impact of a social cognitive theory-based intervention on breakfast consumption among elementary school students

Purpose Breakfast consumption after a night of fasting is crucial for maintaining and improving health, especially during early growth years such as childhood. Therefore, this study was conducted to determine the impact of an educational intervention based on Social Cognitive The...

Preparation of oxygen-filled adipose-derived stem cells exosome-nanobubbles gel for ultrasound-assisted full-thickness wound healing in rats

Effective wound healing is often hindered by hypoxia, inflammation, and impaired angiogenesis. Although mesenchymal stem cell (MSC)-based therapies have shown potential, their clinical application remains limited. As a result, MSC-derived exosomes, particularly adipose-derived st...

Substance use and co-occurring mental health conditions among adolescents and young adults in North America: a systematic review

Abstract Background Substance use and co-occurring mental health conditions are common among adolescents and young adults and represent an important clinical and public health concern in North America. Trauma exposure, psychiatric symptoms, and social adversity frequently co-occu...

Evaluation of sleep quality and obstructive sleep apnea in non-alcoholic fatty liver disease: a cross-sectional study

Abstract Background Sleep is essential for metabolic homeostasis and overall health. NAFLD, recently reclassified as MASLD, is the most prevalent chronic liver disease globally (~ 25% prevalence) and is strongly linked to metabolic comorbidities. Growing evidence associates adver...

Cross-platform transcriptomic integration identifies PDPN for precision prognostic stratification of 1p/19q non-codeleted adult diffuse gliomas

Molecular stratification is central to precision oncology, enabling targeted diagnosis and risk-adapted management of glioma. However, clinically robust transcriptomic biomarkers that refine molecular risk stratification according to 1p/19q status and support personalized diagnos...

Effect of a family-centered empowerment model-based educational intervention on quality of life in women with endometriosis: a randomized controlled trial

Abstract Background Endometriosis substantially impairs disease-specific quality of life across physical, psychological, and social domains, yet evidence regarding family-centered empowerment interventions remains limited. This study evaluated the effect of a family-centered empo...

Clinical outcome in patients undergoing ACL reconstruction in the presence of concomitant MCL injury: a systematic review and meta-analysis

The purpose of this study was twofold: (1) to compare clinical outcomes between operative versus non-operative management of concomitant medial collateral ligament (MCL) and anterior cruciate ligament (ACL)injuries, and to compare clinical outcomes between patients with isolated...

Association between gestational diabetes mellitus and adverse pregnancy outcomes and effect modification by maternal age in a population based cohort study

Abstract Gestational diabetes mellitus (GDM) is a rising public health issue and comes with many negative pregnancy effects for both mothers and infants. Because there is an increasing pattern in advanced maternal age around the globe, it has become very important to know whether...

Recent advances in zeolitic imidazolate framework-based materials for ciprofloxacin removal from aqueous environments

CIP is a widely used fluoroquinolone antibiotic that poses increasing environmental and public health concerns due to its persistence and biological activity in aquatic environments. Zeolitic imidazolate frameworks, known for their high surface area, tunable porosity, and versati...

Development and validation of the Transgender Violence and Discrimination Scale (TVDS)

Violence and discrimination against transgender individuals are significant global health and human rights concerns, yet reliable and valid instruments to measure these experiences are lacking, particularly in the Iranian context. The present study aimed to develop and validate a...

Motor control exercises with and without the McKenzie method of mechanical diagnosis and therapy for fear-avoidance beliefs in chronic low back pain: a two-arm, parallel-group superiority randomized controlled trial protocol

Chronic low back pain (CLBP) is a major cause of disability and is commonly associated with psychological factors such as fear-avoidance beliefs and reduced pain self-efficacy. Motor control exercises aim to improve spinal stability, while the McKenzie method of mechanical diagno...

Late recurrence after radical nephrectomy for renal cell carcinoma in a patient with horseshoe kidney: a case report

Introduction: Horseshoe kidney (HSK) is the most common renal fusion malformation. Renal cell carcinoma (RCC) is the most prevalent malignancy reported in this anomaly. Case presentation: We present the case of a 61-year-old man with multiple recurrences of RCC in the context of...

The Potential Role of 99mTc-FAPI SPECT/CT in the Staging of Mucinous Appendiceal Adenocarcinoma

We present a 55‑year‑old woman with adnexal masses and elevated CEA. Malignancy workup, adnexal biopsy, and intraoperative assessment revealed the appendix as the primary site, with pathology confirming mucinous adenocarcinoma. While mucinous tumors often show limited avidity on...

A qualitative evaluation of dengue surveillance system implementation in southern Iran following autochthonous transmission

Dengue fever, a re-emerging mosquito-borne viral disease, poses an escalating global health threat exacerbated by climate change and globalization. While Iran has historically reported only imported dengue cases, autochthonous transmission has been documented in southern province...

Climate change and cardiovascular diseases: a review of systemic challenges, policies, and management strategies

Climate change threatens cardiovascular health, yet health-system responses remain underexamined. This scoping review maps pathways linking climate change to cardiovascular diseases (CVDs), identifies health-system challenges, and synthesises global, regional, and national polici...

Determination of Efficacy of Intervention based on the Cognitive-Behavioral Therapy Model of Panic Attack Treatment in Comorbid Heart Diseases: A Pilot Randomized Controlled Trial

Background: Panic disorder (PD) and cardiovascular disease (CVD) exhibit similar symptoms, such as palpitations, dyspnea, and chest pain, complicating clinical differentiation, especially when they coexist. This overlap has led to challenges in the context of psychocardiology, in...

Association between ankle–brachial index and body composition parameters measured by bioelectrical impedance analysis in patients with high-risk type 2 diabetes mellitus: a cross-sectional study

Abstract Background Peripheral arterial disease (PAD) is a common macrovascular complication of type 2 diabetes mellitus (T2DM) associated with substantial morbidity. The ankle-brachial index (ABI) is a simple, non-invasive, and widely recommended tool for PAD screening, while al...

Introducing Mid‐Level Dental Providers in Iran: Challenges and Opportunities

ABSTRACT Objectives The WHO Global Strategy and Action Plan on Oral Health 2023–2030 encourages innovative approaches such as shifting tasks from dentists to Mid‐level Dental Providers (MLDPs), who work independently to improve access to and equity in oral health. This study aime...

Synergistic effects of Tschimgine combined with 5-Fluorouracil against HT-29 human colorectal cancer cells

Colorectal cancer (CRC) represents a leading cause of cancer morbidity and mortality globally. Tschimgine (Tsc), a naturally occurring terpenoid from Ferula ovina , has exhibited potent anticancer activity in preclinical models. However, its ability to enhance the sensitivity of...