Mashhad University of Medical Sciences

True Versus Sham Thread Embedding Acupuncture for Spasticity-Related Symptoms and Disabilities in Multiple Sclerosis: Study Protocol of a Randomized Controlled Trial

Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease and one of the most common causes of non-traumatic disability in young adults, with over 2.8 million individuals worldwide. Spasticity affects nearly 80% of people with MS (PwMS), contributing to pain, gait dis...

Berberine as a Mitochondrial Metabolic Reprogrammer in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Adaptive Energetic Stress, Quality Control, and Translational Limitations

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to mitochondrial dysfunction, including altered oxidative phosphorylation, disrupted fatty-acid oxidation, redox imbalance, abnormal mitochondrial dynamics, and impaired quality control. Berberine...

A Rare Association: Gliomatosis Peritonei and Giant Mature Cystic Teratoma: A Case Report

Mature cystic teratomas are the most common ovarian germ cell tumors. However, the rare coexistence of mature teratomas with gliomatosis peritonei, a condition characterized by mature glial tissue implantation in the peritoneum, poses significant diagnostic and therapeutic challe...

Salivary nanobiosensors for oral diseases: from biomarker discovery to clinical translation in precision dentistry

INTRODUCTION: Current diagnostic approaches to oral disease have limitations, highlighting the need for rapid, sensitive, and accessible technologies for routine clinical use. Biosensors can evaluate a wide range of biomarkers in oral conditions, including periodontal diseases, o...

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

The tumor microenvironment (TME) is a complex and heterogeneous milieu encompassing biological and biochemical events and diverse physical, chemical, and mechanical interactions between tumor and stromal cells. This heterogeneity plays a pivotal role in regulating tumor progressi...

The impact of aromatherapy with passiflora oil on the sleep quality of patients undergoing hemodialysis: a randomized controlled trial

The prevalence of sleep disorders is high among patients undergoing hemodialysis. Hemodialysis patients, often constrained in using conventional sleep medications, face challenges in sleep quality. This study explores the potential impact of Passiflora oil on the sleep quality of...

Cell-free supernatant of Limosilactobacillus reuteri enhances 5-fluorouracil-induced apoptosis in SW-480 colorectal cancer cells: an in vitro study

5-fluorouracil (5-Fu) is a main treatment for colorectal cancer (CRC) but shows limited efficacy and serious side effects, creating a need for novel adjunct therapies. Recent evidence suggests Limosilactobacillus reuteri derivatives may have anticancer properties. Accordingly, th...

Exploring medical interns’ perceptions and satisfaction with task-based microlearning in an otolaryngology rotation: a mixed-methods study

Abstract Background The integration of traditional and modern educational approaches in contemporary curricula, particularly in medical education, is becoming increasingly necessary. Medical schools and healthcare institutions are seeking to enhance the effectiveness and efficien...

Long term operation of dual chamber microbial fuel cells for energy production and monitoring physicochemical changes of landfill leachate treatment

Abstract The present study investigates the efficiency of dual-chamber microbial fuel cells (DC-MFCs) in treating municipal landfill leachate at different concentrations (100%, 75%, 50% and 25%) during a 60-day batch operation. A DC-MFC with an anode volume of 1300 ml and a catho...

Associations of VDR gene polymorphisms and haplotypes with dental caries: a systematic review and meta-analysis

Dental caries is one of the most prevalent chronic oral diseases worldwide. The higher occurrence of dental caries in some individuals despite good oral hygiene suggests that genetic factors may influence susceptibility. This systematic review and meta-analysis evaluated the asso...

Prevalence and root canal configuration of C-shaped canals in mandibular first and second molars: a retrospective cross-sectional CBCT study in a northern Iranian population

Abstract Background C-shaped canal systems show marked anatomical variation along the root and can complicate cleaning, shaping, and obturation. This study estimated their patient- and tooth-level prevalence and described their cross-sectional configurations in mandibular first a...

Emotional disclosure for alleviating depression, anxiety, and stress in women after spontaneous abortion: a randomized controlled trial

Abstract Background Abortion is a common outcome of pregnancy and may result in significant psychological challenges. Emotional expression has demonstrated positive effects on mental health in various populations. However, few studies have examined its effectiveness specifically...

Optimizing alginate-based delivery systems to enhance adipose-derived stem cell functionality in regenerative medicine: a comprehensive review

This review explores the potential of alginate-based delivery systems for adipose-derived stem cells (ASCs) in regenerative medicine, with a focus on recent strategies that enhance ASC survival, functionality, and therapeutic efficacy. A structured literature analysis was perform...

Factors affecting the prediction of health care costs in cardiovascular patients using artificial intelligence tools: a systematic review of regression and machine learning approaches

Abstract Introduction Cardiovascular diseases (CVDs) are a public health issue in many countries and the primary cause of disease burden worldwide, leading to the increasing cost of health care. Artificial intelligence (AI) and machine learning (ML) tools offer promising solution...

Harnessing ferroptosis as a potential strategy for radiosensitization and cancer control

Cancer continues to be one of the primary causes of deaths across the world. One of the key factors that make it difficult to manage the disease is therapy resistance which is commonly attributed to anti-apoptosis signaling. Ferroptosis, an iron-dependent form of regulated cell d...

Influence of Various Tooth Preparation Designs on Stress Distribution in Anterior Ceramic Veneers: A Systematic Review of Finite Element Analysis Studies

ABSTRACT Objective This systematic review compared the stress distribution patterns in anterior ceramic veneers with different tooth preparation designs by evaluating finite element analysis (FEA) studies, aiming to improve understanding of this biomechanical aspect related to cl...

Beyond Narrative and Tabular Synthesis: Introducing an Approach–Rationale–Note (ARN) Framework for Thematic Evidence Synthesis in Economic Evaluation Reviews

Conventional evidence synthesis in systematic literature reviews (SLRs) of economic evaluations typically provides a narrative description of modelling approaches used across studies and rarely examines the underlying rationale for these choices or their interpretation. This stud...

Electric Uterine Massager (EUM) device versus manual uterine massage for postpartum bleeding and pain after vaginal delivery: study protocol for a randomized controlled trial

Postpartum hemorrhage and postpartum pain are common concerns after vaginal delivery. Manual uterine massage is routinely used in many settings; however, it is operator-dependent and may be uncomfortable for mothers, with inconsistent evidence regarding its effectiveness. Technol...

A pathway model of the predictors of professional psychological help-seeking intentions in adults

Abstract Objective Many people who have suicidal thoughts or engage in related behaviors do not seek help from mental health professionals. The reasons for this are complex and have not been well-studied in our society. Therefore, this study aimed to investigate variables related...

Preparation of oxygen-filled adipose-derived stem cells exosome-nanobubbles gel for ultrasound-assisted full-thickness wound healing in rats

Effective wound healing is often hindered by hypoxia, inflammation, and impaired angiogenesis. Although mesenchymal stem cell (MSC)-based therapies have shown potential, their clinical application remains limited. As a result, MSC-derived exosomes, particularly adipose-derived st...