Mashhad University of Medical Sciences

Late recurrence after radical nephrectomy for renal cell carcinoma in a patient with horseshoe kidney: a case report

Introduction: Horseshoe kidney (HSK) is the most common renal fusion malformation. Renal cell carcinoma (RCC) is the most prevalent malignancy reported in this anomaly. Case presentation: We present the case of a 61-year-old man with multiple recurrences of RCC in the context of...

The Potential Role of 99mTc-FAPI SPECT/CT in the Staging of Mucinous Appendiceal Adenocarcinoma

We present a 55‑year‑old woman with adnexal masses and elevated CEA. Malignancy workup, adnexal biopsy, and intraoperative assessment revealed the appendix as the primary site, with pathology confirming mucinous adenocarcinoma. While mucinous tumors often show limited avidity on...

Climate change and cardiovascular diseases: a review of systemic challenges, policies, and management strategies

Climate change threatens cardiovascular health, yet health-system responses remain underexamined. This scoping review maps pathways linking climate change to cardiovascular diseases (CVDs), identifies health-system challenges, and synthesises global, regional, and national polici...

A qualitative evaluation of dengue surveillance system implementation in southern Iran following autochthonous transmission

Dengue fever, a re-emerging mosquito-borne viral disease, poses an escalating global health threat exacerbated by climate change and globalization. While Iran has historically reported only imported dengue cases, autochthonous transmission has been documented in southern province...

Determination of Efficacy of Intervention based on the Cognitive-Behavioral Therapy Model of Panic Attack Treatment in Comorbid Heart Diseases: A Pilot Randomized Controlled Trial

Background: Panic disorder (PD) and cardiovascular disease (CVD) exhibit similar symptoms, such as palpitations, dyspnea, and chest pain, complicating clinical differentiation, especially when they coexist. This overlap has led to challenges in the context of psychocardiology, in...

Association between ankle–brachial index and body composition parameters measured by bioelectrical impedance analysis in patients with high-risk type 2 diabetes mellitus: a cross-sectional study

Abstract Background Peripheral arterial disease (PAD) is a common macrovascular complication of type 2 diabetes mellitus (T2DM) associated with substantial morbidity. The ankle-brachial index (ABI) is a simple, non-invasive, and widely recommended tool for PAD screening, while al...

Introducing Mid‐Level Dental Providers in Iran: Challenges and Opportunities

ABSTRACT Objectives The WHO Global Strategy and Action Plan on Oral Health 2023–2030 encourages innovative approaches such as shifting tasks from dentists to Mid‐level Dental Providers (MLDPs), who work independently to improve access to and equity in oral health. This study aime...

Synergistic effects of Tschimgine combined with 5-Fluorouracil against HT-29 human colorectal cancer cells

Colorectal cancer (CRC) represents a leading cause of cancer morbidity and mortality globally. Tschimgine (Tsc), a naturally occurring terpenoid from Ferula ovina , has exhibited potent anticancer activity in preclinical models. However, its ability to enhance the sensitivity of...

CONRep: Uncertainty-Aware Vision-Language Report Drafting Using Conformal Prediction

The objective of this study is to quantify uncertainty in vision-language model (VLM)-based automated radiology report drafting (ARRD) to support trustworthy clinical deployment. In this study, we developed CONRep in two settings: label-based and sentence-based. In the label-base...

Delayed intravesical migration of an intrauterine device (IUD) and subsequent successful pregnancy: a case report of diagnostic and surgical challenges

Intrauterine devices (IUDs) are among the most effective and widely utilized methods of reversible contraception. Although uterine perforation and extrauterine migration are uncommon, delayed diagnosis may lead to serious complications involving adjacent pelvic organs, including...

Age- and sex-specific predictive performance of obesity indices for hypertension in the Persian (Shahedieh) cohort study

The rising global prevalence of obesity and its associated negative health outcomes impose a substantial burden on healthcare systems. This study aimed to investigate the predictive power of obesity-related indices for hypertension (HTN) in an Iranian population. This prospective...

Relationship between radiosensitivity of peripheral blood lymphocytes, breast cancer cells, and breast cancer stem cells in patients with breast cancer

Radiosensitivity (RS) is an important biological factor that may contribute to future radiotherapy individualization. However, a comprehensive metric that adequately captures the complexities of radiation sensitivity has not yet been proposed, and the survival fraction at 2 Gy (S...

A novel homozygous GLB1 pathogenic variant identified in two cases of infantile GM1 gangliosidosis

GM1 gangliosidosis is a rare genetic disorder that affects lysosomes. It is caused by variants in the GLB1 gene, which leads to a lack of the enzyme β-galactosidase. The infantile form (Type I) is the most severe. It begins in the first months of life and has a poor prognosis. We...

Correlation of Epstein–Barr virus (EBV) expressed miRNAs (BART4, BART7, and BHRF1) with chronic lymphocytic leukemia stages

Epstein-Barr virus (EBV) has been shown to play a role in the pathogenesis of several B-cell malignancies, but its role in chronic lymphocytic leukemia (CLL) remains unclear. EBV-encoded microRNAs, including BHRF1 and BART families, are thought to modulate host cell survival and...