Masaryk University

Ovarian cancer tumor immune microenvironment and its clinical trial implications

Abstract Ovarian cancer is the most lethal gynecologic malignancy, primarily because of late-stage diagnosis, rapid disease progression, and marked molecular and immunologic heterogeneity. It remains the leading cause of gynecologic cancer-related death, affecting approximately 1...

Combining chemotherapy and cold atmospheric plasma treatment: Empirical and theoretical insights

Chemotherapy remains a cornerstone in oncology, but drug resistance and dose-dependent side effects limit its efficacy. Cold atmospheric plasma emerges as a powerful tool that can sensitize cancer cells and synergize with chemotherapy. It is an ionized gas and an exogenous source...

Clinicopathological Characteristics and Outcomes of Primary Parotid Gland Carcinomas in the Czech Republic: a Multicenter Retrospective Cohort Study of 453 Surgically Treated Patients

Parotid gland carcinomas are rare malignancies with marked histological and biological heterogeneity. Most published evidence is derived from single-center or selected institutional series, whereas comprehensive nationwide epidemiological data remain limited. The aim of this stud...

The major cluster merger in Abell 2034 as seen by XRISM: Strong turbulence and spectral anomalies?

XRISM observations to date have shown that gas kinetic pressures in the intracluster medium (ICM) tend towards the low end of predictions from cosmological simulations. Here, we present a XRISM observation of the merging cluster Abell 2034, which exhibits the broadest emission li...

Grassland destruction causes shifts in plant traits that persist during recovery

Old-growth grasslands assemble over millennia and support high biodiversity and many ecosystem services, but continue to undergo widespread destruction for production of crops, timber, and minerals. How biodiversity recovers after grassland destruction and the functional conseque...

P1.106. Proteomic Signatures of Chemoresistance in Oesophageal Adenocarcinoma Cell Models

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Oesophageal adenocarcinoma is a rapidly rising cancer with poor prognosis. Despite advances in surgery, chemotherapy, and targeted therapy, five-year survival remains below 20%. Treatment failure is largely...

Relating biomarkers and phenotypes using dynamical trap spaces

Connecting the dynamics of biomolecular networks to experimentally measurable cell phenotypes remains a central challenge in systems biology. Here, we introduce a model-based definition of phenotype as a partial steady state that is committed to a certain dynamical outcome while...

Symmetry-Broken Biphasic WS2 NanowhiskeredHeterostructures Enable Field-Induced NO2 Sensing

Abstract Van der Waals (vdW) materials have garnered ample interest as next-generation sensors and catalysts, owing to high surface-to-volume ratio, defect tunability, easy modulation of active sites, and convenience in device fabrication. However, one major drawback delimiting s...

Availability and representativeness of freshwater macroinvertebrate data to enable Europe-wide assessment of biodiversity trends

Freshwater ecosystems, though covering less than 1% of Earth's surface, harbor around 10% of all species. Pressures like pollution, water extraction, and habitat loss can exhibit complex interactions in their effects on freshwater biodiversity. Understanding the effects of these...

Percentiles for crying, regurgitation, stool consistency, and CoMiSSTM in presumed healthy infants

Parents frequently consult health care professionals because of infant regurgitation, crying and stool consistency. The Cow’s Milk-related Symptom Score (CoMiSS TM ) is an awareness tool for cow’s milk allergy. We aimed to characterize the distribution of CoMiSS items in presumed...

Acute effects of moderate-intensity continuous and high-intensity interval exercise on vascular function

Abstract Purpose To assess and compare the acute effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on central and peripheral arterial stiffness, as well as endothelial and microvascular reactivity in healthy, physically active ad...

Integration or stratification? Cumulative advantage and prestige homophily in the CEEPUS inter-university network

Abstract International student mobility is often framed as an integrative policy instrument, yet mobility systems frequently display durable inequalities and core–periphery structures. This study examines whether a regionally bounded program outside Western Europe’s historical ac...

Extending the mineralogy of U 6+ (VII.): Kristekite, [Cu 2 (H 2 O) 4 (UO 2 )(SeO 3 ) 3 ]·4H 2 O, a new mineral from Příbram, Czech Republic.

The new mineral kristekite (IMA2025-101), [Cu 2 (H 2 O) 4 (UO 2 )(SeO 3 ) 3 ]•4H 2 O, was found in the dump material of the former uranium mine at Bytíz, near Příbram, Central Bohemia, Czech Republic, where it occurs as hedgehog-like aggregates, consisting of yellowish-green tabu...

Liddicoatite, Ca(Li2Al)Al6(Si6O18)(BO3)3(OH)3OH, a rare, long-anticipated OH-dominant species of the tourmaline supergroup

Abstract Liddicoatite, ideally Ca(Li2Al)Al6(Si6O18)(BO3)3(OH)3OH, is a new mineral species of the tourmaline supergroup and the OH-dominant analogue of fluor-liddicoatite. The name liddicoatite was originally applied to a species that was subsequently renamed fluor-liddicoatite f...

Upconverting vs. fluorescent labels for visualizing distribution and uptake of nanoplastics: a Daphnia magna case study

Micro- and nanoplastics (MNPLs) are pervasive environmental contaminants, raising concerns for ecosystems and human health. Nanoplastics (NPLs), in particular, present unique analytical challenges due to their minute size, which makes their detection and study in complex biologic...

When turnover isn’t over

Early career teacher turnover remains a persistent challenge for educational systems worldwide, yet the processes shaping decisions to leave the profession are still insufficiently understood. Responding to calls for a more in-depth and contextualised approach, this article prese...

Timing pattern of Common Cuckoo parasitism and its relation to host nest attendance

Classical works show the adaptive importance of precise timing of egg‐laying in brood parasitic Common Cuckoos Cuculus canorus to ensure sufficient incubation time and successful hatching. Laying in the late afternoon has been suggested to increase the chance of secretive parasit...

Digitally Supported Trust in Social Work With Children of Incarcerated Parents

ABSTRACT Children of incarcerated parents are frequently overlooked despite the effects of parental incarceration on their well‐being, relational security, social inclusion and participation. This article examines the conditions under which digital social work can support relatio...

Comparative host–graft biomechanics of osteoarticular allografts and allograft–prosthesis composites after distal femoral tumor resection

Abstract Background Distal femoral reconstruction after tumor resection can be performed using osteoarticular allografts (OCH) or allograft–prosthesis composites (APC). Although both techniques restore bone stock, complications such as nonunion, graft fracture, and hardware failu...