Masaryk University

Is exercise-reporting quality associated with vascular benefits of aerobic training in individuals with cardiovascular disease? A systematic review and meta-analysis of randomized controlled trials

Abstract Exercise is a key non-pharmacological intervention for managing cardiovascular diseases (CVDs), yet the quality and completeness of exercise reporting in randomized controlled trials (RCTs) remain inconsistent. This systematic review and meta-analysis evaluates how well...

Reaction of Cysteine and Selenocysteine with a Model Au(I)-N-Heterocyclic Carbene Complex: A QM and QM/MM MD Comparative Study

Abstract The substitution reaction of a model Au(I)-N-heterocyclic carbene (NHC) complex with cysteine and selenocysteine represents a key elementary step in the inhibition mechanism of thioredoxin reductase by gold-based metallodrugs. We present a systematic quantum-mechanical (...

Comparative evaluation of four household food‑waste composting systems for decentralized circular waste management

Abstract The study evaluated four household food waste composting systems using replicated trials ( n = 3 per device) with standardized feedstock loads to compare temperature dynamics, physicochemical parameters, compost maturity, and microbiological safety. Although electric uni...

Delivery of cardiac rehabilitation through hybrid models and alternative settings by country income classification and decade: Comparisons from the International Council of Cardiovascular Prevention and Rehabilitation’s 2025 Global Audit Update

Objective Cardiac rehabilitation (CR) is an outpatient model of secondary prevention that improves patient outcomes, yet use remains limited. Hybrid/alternative CR addresses these challenges, but global availability, structure, and volumes have not been characterized since the pa...

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

European joint programme HBM4EU - Bridging science and policy: experiences and lessons learned from the key partners in the scientific steering of the initiative

The European Joint Programme HBM4EU was established to address politically relevant questions on chemical risks to public health through a targeted human biomonitoring research programme. Running from 2017 to 2022, it was co-financed by the EU's Horizon 2020 Research and Innovati...

Periodontal health and chitinase 3-like-1 levels in autoimmune rheumatic diseases and osteoarthritis: a pilot study

Autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), often co-exist with periodontitis (PD). Both diseases share inflammatory pathways and common risk factors, suggesting a potential interplay. This study evaluates the association between periodontal health an...

Did the language of medieval inquisition records become richer over time? A diachronic lexical richness perspective on heresy trial proceedings from Languedoc and Italy, 1231–1400

While medieval inquisition records have a reputation for containing standardized and formulaic administrative language, some display a thematic richness and discursive variety that extends beyond the norm, especially in records of depositions. There is also a notion that register...

Sacituzumab govitecan in heavily pretreated metastatic triple-negative breast cancer: a secondary analysis of the CEBCC-102 real-world cohort

Abstract Background Real-world evidence on sacituzumab govitecan (SG) in heavily pretreated patients with metastatic triple-negative breast cancer (mTNBC) remains limited. This study assessed SG outcomes in a multicentre Central European cohort. Methods This retrospective study i...

Mitochondria-Disrupting Aminocarbyne−DMAP Diiron(I) Complexes Perturb Iron Homeostasis with Marginal ROS Contribution in Cancer Cells

Abstract Five diiron complexes, [Fe2Cp2(CO)(dmap)(μ-CO){μ-CN(Me)(R)}]CF3SO3 (3a-e), were synthesized from readily available tris-carbonyl precursors and characterized. The complexes display ≈10−4 M aqueous solubility, amphiphilicity, and 50−74% of intact complex remaining after 7...

A global study of novel agents in paediatric and adolescent relapsed and refractory B-cell non-Hodgkin lymphoma (Glo-BNHL): protocol for an adaptive international platform clinical trial

The second Paediatric Strategy Forum of the international multi-stakeholder organisation, ACCELERATE (Nov-2017), concluded that an international approach to conducting clinical trials in relapsed and refractory paediatric B-cell non-Hodgkin lymphoma (r/r B-NHL) was critical and t...

The WoKaS-Iso database: workflow for a global compilation of oxygen-18 and deuterium records in karst springs and cave drip water for enhanced understanding of karst systems

For analysing karst hydrogeological systems, observations of karst springs and cave drips are considered indispensable. In addition to hydrometric observations, knowing the oxygen and hydrogen stable isotope ratios has improved the understanding of vadose zone and aquifer dynamic...

Classification of quaternionic skew-Hermitian symmetric spaces

Abstract We provide a complete classification of quaternionic skew-Hermitian symmetric spaces, namely symmetric spaces that admit a torsion-free $${{\,\mathrm{\textsf{SO}}\,}}^*(2n){{\,\mathrm{\textsf{Sp}}\,}}(1)$$ SO ∗ ( 2 n ) Sp ( 1 ) -structure for arbitrary $$n>1$$ n > 1 . Mo...

Rising performance-efficiency demands in female junior tennis: A longitudinal analysis of ITF World Tennis Tour Juniors rankings, 2004–2025

Long-term changes in ranking-point production efficiency among female players on the ITF World Tennis Tour Juniors were examined between 2004 and 2025. Year-end ranking data comprised 8,510 player-year observations from 5,919 players aged 12–18 years. Elite status was defined ann...

In vitro contact force evaluation of robotic magnetic navigation catheters; Head to head comparison of different catheters and different settings

Background The Stereotaxis Robotic Magnetic Navigation (RMN) system uses an external magnetic field to navigate catheters inside the heart during arrhythmia ablation. This study compared in vitro maximal contact force (CF) achieved with different irrigated RMN ablation catheters...

Fault Slip Reversals Preceded the Intraplate 2021 Earthquake Series in the Vienna Basin (Central Europe)

Abstract Fault‐slip reversals indicate transient stress changes and may illuminate earthquake preparation processes. Here we present high‐resolution observations of sub‐millimetric creep and slip reversals on the Altaquelle Fault, a Quaternary normal fault in the southern Vienna...

Pronouns, publics, and power

Abstract This study examines how multilingual governance is enacted through first-person plural pronoun choice in Singapore Prime Minister Lee Hsien Loong’s National Day Rally speeches (2004–2023). It analyses we , kita , and kami for how English and Malay versions address distin...

Spatiotemporal expression dynamics of CD73 , CD90 , and CD105 based on scRNA ‐seq and immunofluorescence analysis of dental pulp toward establishing a triple‐positive population

Abstract Dental pulp stem cells (DPSCs), a subset of mesenchymal stem/progenitor cells, exhibit remarkable self‐renewal and multipotent differentiation capacity, making them promising candidates for regenerative applications. While their in vitro characteristics have been extensi...

Atlas of cell types and regulatory elements underlying human facial diversity

Abstract Human genetic diversity generates an astonishing variety of facial shapes, and craniofacial anomalies rank among the most common birth defects. Identifying the cellular mechanisms that mediate the genome’s influence on facial variation remains a challenge. Here we create...

Integrated Structural, Physicochemical, Pharmacokinetic and Pharmacodynamic Evaluation of Substituted Phenylcarbonyloxypiperazinopropanols as Antimycobacterial Agents

This research aimed to evaluate structural, physicochemical and pharmacokinetic characteristics of racemic 2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl 4-[(alkoxycarbonyl)amino]benzoates (Ib)–(IVb) and 2-hydroxy-3-[4-(R-substituted phenyl)piperazin-1-yl]propyl 4-[(alkoxycarbonyl)am...