Institution
Mansoura University
Recent research
- Health & Medicine
ABSTRACT Monoclonal gammopathy of undetermined significance (MGUS) is a common asymptomatic plasma cell disorder and the major precursor state of multiple myeloma (MM). Although progression is partly shaped by intrinsic genetic and epigenetic changes within the plasma cell clone,...
- Health & MedicineOpen access
Abstract Pediatric disorders consist of genetic, hematologic, neurologic, autoimmune, and inflammatory diseases. These conditions impose long-term health challenges on children, despite many advancements with conventional medicine. Although conventional treatments increase life e...
- Engineering & TechnologyOpen access
Abstract The Internet of Robotic Things (IoRT) has introduced new possibilities for distributed and scalable robotic control by combining industrial manipulators with cloud-based computation and networked communication infrastructures. However, the deployment of cloud-assisted ro...
- Health & MedicineOpen access
Role of feature tracking cardiac MRI in evaluation of ischemic cardiomyopathy
Abstract Background Ischemic cardiomyopathy (ICM) is characterized by profound left ventricular (LV) remodelling, impaired systolic function, and variable myocardial viability. Cardiac magnetic resonance feature tracking (CMR-FT) enables non-invasive quantification of myocardial...
- Health & MedicineOpen access
Background: Cisplatin is a widely used chemotherapeutic agent whose gonadotoxic effects, largely driven by oxidative stress and inflammation, pose a major threat to male reproductive health. This study evaluated whether hesperetin (HES) and hesperetin-loaded poly (lactic-co-glyco...
- Health & MedicineOpen access
Beclin-1 and HIF-1α immunohistochemical expression in breast carcinoma: insights into tumor biology
Breast carcinoma is a biologically heterogeneous disease in which tumor behavior and clinical outcome are influenced by multiple cellular pathways, including autophagy and hypoxia. Beclin-1, a key autophagy-related protein, and hypoxia-inducible factor-1α (HIF-1α), a central regu...
- Health & MedicineOpen access
Pyrazolo[3,4-b]pyridine: a privileged scaffold for the synthesis of anti-Alzheimer’s agents
Abstract Alzheimer’s disease (AD) is known to be the most prevalent neurodegenerative disorder that results in dementia and causes a variety of cognitive symptoms. There are many important aspects of AD that should be considered, even though the exact sequence of events is unclea...
- BiologyOpen access
Abstract The rapid emergence of antibiotic resistance represents a critical global health challenge, particularly in biofilm-associated infections caused by Pseudomonas aeruginosa ( P. aeruginosa ). Quorum sensing plays a pivotal role in regulating bacterial virulence and biofilm...
- Biology
Early-Life Antibiotic Exposure Disrupts Bifidobacterium in Infants: A qPCR-Based Cohort Study
BACKGROUND: Early infancy represents a critical window for establishing the gut microbiome, during which Bifidobacterium species dominate and play essential roles in metabolic, immune and intestinal maturation. Antibiotic exposure during this sensitive period may disrupt microbia...
- Health & Medicine
Systematic evidence review on radiosensitizers and the abscopal effects of radiotherapy
BACKGROUND: The abscopal effect, defined as regression of non-irradiated tumors following localized radiotherapy (RT), is increasingly recognized as an immune-mediated phenomenon. Radiosensitizers may enhance this effect by amplifying radiation-induced immunogenicity and systemic...
- Health & MedicineOpen access
The Lipid Accumulation Product (LAP) is recognized as an indicator of lipid-induced cellular stress. While its predictive value for conditions like diabetes, liver disease, and metabolic syndrome is established, its specific correlations with individual metabolic and hematologica...
- Society & Economics
The impact of religiosity and enforcement on ESG decoupling: an international study
Purpose This paper investigates how religiosity affects environmental, social and governance (ESG) decoupling. It also examines how enforcement quality moderates this relationship. Design/methodology/approach Using a dataset of 34,330 firm-year observations from 29 countries (200...
- Society & EconomicsOpen access
Older adults are disproportionately affected by nature-induced and human-made disasters. Media can support preparedness by disseminating timely guidance, but high-intensity exposure to distressing coverage and misinformation can also increase anxiety and impede action. This narra...
- BiologyOpen access
OBJECTIVE: This study evaluates the efficacy and outcomes of endoscopic third ventriculostomy combined with choroid plexus cauterization (ETV + CPC) as a primary treatment for hydrocephalus associated with Chiari II malformation in infants. METHODS: This retrospective study analy...
- Biology
ABSTRACT Diabetic steatohepatitis, now clinically framed within metabolic dysfunction‐associated steatohepatitis (MASH), features progressive disruption of hepatic microarchitecture alongside sterile inflammatory microdomains. Farnesoid X receptor (FXR) activity is restrained by...
- Health & MedicineOpen access
Background: Diclofenac is a widely consumed non-steroidal anti-inflammatory drug, yet its clinical utility is limited by severe hepatotoxicity, acute kidney injury, and gastric ulceration. While the RhoA/ROCK pathway is implicated in inflammation, its potential as a therapeutic t...
- Health & MedicineOpen access
Background: Doxorubicin-induced cardiotoxicity (DIC) is a major limitation of anthracycline chemotherapy and is characterized by oxidative stress, apoptosis, and myocardial remodeling. Dysregulation of AMP-activated protein kinase (AMPK) and its downstream effector sirtuin-1 (SIR...