Mansoura University

Carcinogenic and non-carcinogenic health risks associated with heavy metal exposure in commonly consumed marine fish in Egypt

Abstract This study aimed to quantify the levels of mercury (Hg), arsenic (As), lead (Pb), and cadmium (Cd) in 250 fish samples, including flathead grey mullet, sardine, and mackerel, collected from local fish markets in Mansoura, Egypt, on ten occasions from August 2023 to March...

LACHT syndrome with branchial cyst in a female infant; case report and review of literature

Lung agenesis is a rare congenital malformation. The combination of lung agenesis, congenital heart defects, and thumb anomalies characterizes LACHT syndrome, an extremely rare condition with an unclear genetic basis. To date, only 15 cases have been reported in the literature. W...

A systematic review of the fabrication and mechanical properties of 3D-printed composite clay bricks

This review investigates recent developments in 3D-printed composite clay bricks, with a particular focus on material innovation, geometric refinement, and mechanical performance. A systematic review supported by bibliometric analysis of seventy peer-reviewed publications from 20...

The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis

Abstract Exercise orchestrates an interorgan communication network, in which skeletal muscle releases signaling molecules known as myokines that contribute to exercise training-induced adaptations. We identified the muscle-derived metabolite beta-aminoisobutyric acid (BAIBA) as a...

Neuro-Symbolic Frameworks for Corporate Leverage and Debt Maturity: Evidence from Econometric and Machine Learning Models

Forecasting corporate leverage adjustments remains challenging due to persistent financing behavior, firm heterogeneity, and changing macroeconomic conditions. This study investigates whether increasing model complexity improves the forecasting of corporate leverage adjustment by...

Critical Prime-Index Support-Span Laws for Integers with a Fixed Number of Distinct Prime Factors

Let N>=2 range over the integers as the size cutoff, and fix an integer r>=2. For an integer n having exactly r distinct prime factors, we measure the number K of omitted global prime indices between its smallest and largest support primes. With M_r(N)=pi(N^(1/r))-pi(N^(1/(r+1)))...

The Transformation of the Microenvironment: From Observer to Coordinator in Monoclonal Gammopathy of Undetermined Significance (MGUS) to Myeloma Development

ABSTRACT Monoclonal gammopathy of undetermined significance (MGUS) is a common asymptomatic plasma cell disorder and the major precursor state of multiple myeloma (MM). Although progression is partly shaped by intrinsic genetic and epigenetic changes within the plasma cell clone,...

Stem cell–based therapies in pediatric disorders: translational advances, unresolved challenges, and future horizons

Abstract Pediatric disorders consist of genetic, hematologic, neurologic, autoimmune, and inflammatory diseases. These conditions impose long-term health challenges on children, despite many advancements with conventional medicine. Although conventional treatments increase life e...

Therapeutic potential of dental follicle-derived stem cells and gold nanoparticles on osteoarthritic temporomandibular joint in guinea pigs (randomized prospective study)

Abstract Background Osteoarthritis (OA) is a complicated autoimmune disease that often causes invasive inflammatory infiltration and serious articular destruction. The global prevalence of temporomandibular disorders (TMDs) is estimated to be around 30% of the population. Several...

Cloud-assisted IoRT framework for latency-aware analytical kinematic control of a six-DOF robotic manipulator

Abstract The Internet of Robotic Things (IoRT) has introduced new possibilities for distributed and scalable robotic control by combining industrial manipulators with cloud-based computation and networked communication infrastructures. However, the deployment of cloud-assisted ro...

Hesperetin-Loaded PLGA Nanoparticles Ameliorate Cisplatin-Induced Oxidative Stress and Testicular Dysfunction in Rats: Association with NRF2/HO-1, NF-κB, and ACSL4/GPX4/SLC7A11 Signaling Modulation

Background: Cisplatin is a widely used chemotherapeutic agent whose gonadotoxic effects, largely driven by oxidative stress and inflammation, pose a major threat to male reproductive health. This study evaluated whether hesperetin (HES) and hesperetin-loaded poly (lactic-co-glyco...

Role of feature tracking cardiac MRI in evaluation of ischemic cardiomyopathy

Abstract Background Ischemic cardiomyopathy (ICM) is characterized by profound left ventricular (LV) remodelling, impaired systolic function, and variable myocardial viability. Cardiac magnetic resonance feature tracking (CMR-FT) enables non-invasive quantification of myocardial...

Beclin-1 and HIF-1α immunohistochemical expression in breast carcinoma: insights into tumor biology

Breast carcinoma is a biologically heterogeneous disease in which tumor behavior and clinical outcome are influenced by multiple cellular pathways, including autophagy and hypoxia. Beclin-1, a key autophagy-related protein, and hypoxia-inducible factor-1α (HIF-1α), a central regu...

Pyrazolo[3,4-b]pyridine: a privileged scaffold for the synthesis of anti-Alzheimer’s agents

Abstract Alzheimer’s disease (AD) is known to be the most prevalent neurodegenerative disorder that results in dementia and causes a variety of cognitive symptoms. There are many important aspects of AD that should be considered, even though the exact sequence of events is unclea...

Disarming Pseudomonas aeruginosa: repurposing vardenafil, valsartan, and olmesartan as anti-virulence and antibiofilm agents

Abstract The rapid emergence of antibiotic resistance represents a critical global health challenge, particularly in biofilm-associated infections caused by Pseudomonas aeruginosa ( P. aeruginosa ). Quorum sensing plays a pivotal role in regulating bacterial virulence and biofilm...

Early-Life Antibiotic Exposure Disrupts Bifidobacterium in Infants: A qPCR-Based Cohort Study

BACKGROUND: Early infancy represents a critical window for establishing the gut microbiome, during which Bifidobacterium species dominate and play essential roles in metabolic, immune and intestinal maturation. Antibiotic exposure during this sensitive period may disrupt microbia...

Systematic evidence review on radiosensitizers and the abscopal effects of radiotherapy

BACKGROUND: The abscopal effect, defined as regression of non-irradiated tumors following localized radiotherapy (RT), is increasingly recognized as an immune-mediated phenomenon. Radiosensitizers may enhance this effect by amplifying radiation-induced immunogenicity and systemic...

Lipid accumulation product (LAP): a key indicator for metabolic dysregulation and inflammatory status in obesity

The Lipid Accumulation Product (LAP) is recognized as an indicator of lipid-induced cellular stress. While its predictive value for conditions like diabetes, liver disease, and metabolic syndrome is established, its specific correlations with individual metabolic and hematologica...

Crisis media exposure cognitive appraisal disaster preparedness and resilience among older adults a narrative review

Older adults are disproportionately affected by nature-induced and human-made disasters. Media can support preparedness by disseminating timely guidance, but high-intensity exposure to distressing coverage and misinformation can also increase anxiety and impede action. This narra...

The impact of religiosity and enforcement on ESG decoupling: an international study

Purpose This paper investigates how religiosity affects environmental, social and governance (ESG) decoupling. It also examines how enforcement quality moderates this relationship. Design/methodology/approach Using a dataset of 34,330 firm-year observations from 29 countries (200...