Mansoura University

Cell-free DNA fragmentomics and epigenomic profiling in hematologic malignancies: current evidence, translational limitations, and future directions

Mutation-based liquid biopsy supports diagnosis and disease monitoring in hematologic malignancies, but interpretation of plasma variants may be complicated by clonal hematopoiesis, treatment-related changes, and nonmalignant blood-cell turnover. This structured narrative review...

Rabies and rabies prophylaxis in Egypt: a nationwide cross-sectional study that calls for action

BACKGROUND: Rabies is a fatal but preventable viral disease that poses a global health threat, especially in developing countries. Despite the high incidence of animal bites reported annually in Egypt, limited data exist regarding the knowledge, attitudes, and practices (KAP) of...

Sex Differences in Presentation, Management, and Prognosis of Surgically Treated Oral Tongue Carcinoma: A Retrospective Cohort Study

AIM: Tongue carcinoma is an aggressive subtype of oral cavity cancer. Sex-related differences in disease presentation and prognosis remain incompletely understood.METHODS: This retrospective cohort study included patients with histologically confirmed oral tongue squamous cell ca...

Dexamethasone-Induced Insulin Resistance and Hepatic Metabolic Dysfunction: Modulatory Effects of Montelukast on SGK1-Associated Signaling and NLRP3/Leukotriene-Related Responses

Background: Glucocorticoid-induced metabolic dysfunction and insulin resistance-related abnormalities are important complications associated with dexamethasone (DEX) exposure. This study investigated the protective effects of montelukast (MNT) against DEX-induced metabolic and he...

Increasing Detection of Early-Onset Rectal Neuroendocrine Neoplasms in the Era of Earlier Colorectal Cancer Screening

Background This study aimed to evaluate contemporary national trends in the presentation, management, and outcomes of early-onset rectal neuroendocrine neoplasms (EORNETs). Methods A retrospective cohort analysis of patients <50 years who underwent surgery for rectal neuroendocri...

Quinones as Optical Signal Transducers: Emerging Roles in Spectroscopic Sensing, Carbon Dots, and Enzyme-Free Immunoassays

Quinones have emerged as versatile optical signal transducers in spectroscopic analytical chemistry because of their unique redox activity, electron-transfer capability, reactive oxygen species generation, and tunable photophysical properties. Beyond their traditional roles as bi...

Early Versus Late Injection Laryngoplasty for Unilateral Vocal Fold Paralysis

ABSTRACT Objectives Unilateral vocal fold paralysis (UVFP) is a condition characterized by the loss of functional movement of one vocal fold resulting in incomplete glottic closure, which compromises essential functions such as phonation, swallowing and coughing. Injection medial...

Morpho-molecular assessment of nanomaterials in teleost fish wound healing: a systematic review

Abstract Background Teleost fish skin is a vital barrier for regulating osmoregulation, immune defense, and respiration. Cutaneous wounds in farmed fish cause significant economic loss and welfare concerns, as standard treatments, like antibiotics and chemical baths, are often in...

Melatonin loaded phytosomes for enhanced therapy against ethanol-induced gastric ulcer: Formulation, optimization and in vitro / in vivo evaluation

Healing of gastric ulcer (GU) can terminate the progression into more serious deteriorations. A promising and versatile vesicular nanoformulation, namely; phytosomes (PHY), was fabricated to maximize the GU healing efficacy of the naturally occurring bioactive component; melatoni...

Cranial anatomy of the Middle Eocene Egyptian crocodylian Herugavialis cairensis provides new insights into gavialoid diversity in the Mediterranean region

Abstract Gavialoidea is presently composed of only two extant crocodylian species, the Indian gharial Gavialis gangeticus, and the false gharial Tomistoma schlegelii, both from southeast Asia. However, Gavialoidea displays a rich and near-cosmopolitan diversity in the fossil reco...

Effects of transcutaneous electrical diaphragmatic stimulation on diaphragmatic function and clinical outcomes in severe chronic obstructive pulmonary disease exacerbations: a randomized controlled trial

Abstract Background Diaphragmatic dysfunction plays a central role in respiratory failure during acute exacerbations of chronic obstructive pulmonary disease (COPD). Transcutaneous electrical diaphragmatic stimulation (TEDS) has emerged as a potential modality to enhance respirat...

Cooperative Modulation of the NF‐κB and p53 Pathways by Metronomic Cyclophosphamide and Metformin Inhibits Ehrlich Carcinoma Progression and Enhances Systemic Immunity

This study investigates the cooperative antitumor potential of combining metronomic cyclophosphamide (MTm-CTX) with the metabolic modifier metformin (MET) in a murine model of mammary carcinoma. While metronomic chemotherapy offers a reduced toxicity profile, its efficacy as a mo...

Prevalence of gastroesophageal reflux disease and associated risk factors among medical students in the MENA region: a multinational cross-sectional study

Abstract We aimed to assess the prevalence of gastroesophageal reflux disease (GERD) among medical students in Middle East countries and its associated risk factors. A multinational cross-sectional study was conducted among medical students in 8 Middle East countries. GERDQ and G...

Nano curcumin as a multifunctional additive in (PVP/SA) blends: structural, optical, and antibacterial insights

Abstract Nano curcumin was incorporated into Polyvinyl pyrrolidone/ Sodium alginate (PVP/SA) blend using casting method. The decrease in amorphousity of PVP/SA polymer blend with increasing nano curcumin content was confirmed by XRD results. FTIR illustrated the coordination or i...

Addiction management and rehabilitation programs in Saudi Arabia: a scoping review of current practices and opportunities for healthcare technology integration

Substance use disorders (SUDs) represent a growing public health challenge in Saudi Arabia despite strict legal and social controls. Addiction management is primarily delivered through centralized inpatient and residential rehabilitation programs; however, the available evidence...

Board Expertise and Firm Profitability: The Moderating Roles of Product Market Competition and Institutional Quality

This paper investigates the association between board expertise and firm profitability. Using an international sample of 42,623 firm-year observations from 2002 to 2021, we find that firms with greater industry and financial expertise on their boards exhibit significantly higher...

Antioxidant treatments combined with refrigerated storage, modified atmosphere packaging, and precooling improve postharvest quality of red cabbage

Abstract Postharvest deterioration of red cabbage involves water loss, oxidative imbalance, membrane damage, and loss of structural and sensory quality. This study evaluated the effects of four food-grade antioxidants—ascorbic acid, citric acid, glutathione, and α-tocopherol—toge...

Q-Conditioning and Q-Gating: Metadata-Driven Attention Mechanisms for Medical Vision Transformers

Background: Vision Transformers (ViTs) have demonstrated efficacy in visual recognition tasks through global dependency modeling via self-attention. However, standard ViT architectures lack native mechanisms for integrating external clinical metadata (e.g., patient demographics,...

A new heat sink for cooling photovoltaic systems using a honeycomb heat sink filled with multiple phase change materials

The electrical efficiency of photovoltaic (PV) cells is significantly influenced by their operating temperature. As the temperature increases, the power output decreases; therefore, effective thermal management is essential to maintain conversion efficiency and maximize energy pr...

Phenotypic spectrum and quality of life in pediatric Bruck syndrome due to FKBP10 and PLOD2 variants: a 2-center United Arab Emirates experience.

Bruck syndrome is a rare autosomal recessive form of OI caused by biallelic variants in FKBP10 or PLOD2, and characterized by fragility fractures with congenital or progressive joint contractures. We describe 13 patients from 2 tertiary pediatric centers in the United Arab Emirat...