Mansoura University

Recent advances in molecular mechanisms to improve the efficacy of CAR-T cell therapy for viral diseases, cancer, and autoimmune diseases

Abstract Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment of hematological malignancies, yet its broader application to solid tumors, chronic viral infections, and autoimmune diseases remains constrained by antigen heterogeneity, immunosuppressive tiss...

Molecular modeling characterization of cellulose and chitosan metal oxide hybrid interfaces

Abstract The interfacial electronic structure of biopolymer–metal oxide hybrids determine their stability, yet this structure is still not well understood. Here, we report a density functional theory study of 10 model systems consisting of cellulose and chitosan functionalized wi...

Empagliflozin mitigates lipopolysaccharide-induced tracheal injury in rats via downregulation of IL-6/JAK/STAT3 signaling pathway and stem cell preservation: histological and molecular study

Abstract Lipopolysaccharide (LPS) is a component of the Gram-negative bacterial cell wall and is considered a potent inflammatory inducer. Empagliflozin (EMPA) is a sodium-glucose co-transporter 2 inhibitor used in treatment of type 2 diabetes mellitus. Interleukin-6/Janus kinase...

Deep learning-based multi-class misbehavior classification in fog-enabled vehicular ad hoc networks

Abstract Traffic collisions and congestion represent significant challenges within intelligent transportation systems (ITS). Consequently, a vehicular ad-hoc network (VANET) has been established. Numerous architectures have been incorporated into VANETs to manage the extensive da...

High-performance computing in the hydrosciences

This paper provides an overview of High Performance Computing (HPC) in the hydrosciences. It begins with the development of HPC architectures and performance as well as with the expansion of application fields over the last decades. Subsequently, four HPC application cases are pr...

Effects of probiotic supplementation on disease progression in patients with moderate to severe chronic kidney disease: a randomized controlled trial

Abstract Chronic kidney disease (CKD) affects approximately 10% of the global population, with limited therapeutic options to slow progression in moderate stages. The gut-kidney axis contributes to CKD progression, and probiotics are being investigated as potential therapeutic mo...

Crashworthiness optimization of biodegradable 3D-printed structures via geometric triggers and fuzzy Logic integration

This study investigates the crashworthiness of 3D-printed Polylactic Acid (PLA+) thin-walled tubes with engineered geometric cut-outs under quasi-static axial compression. Using a Taguchi L18 orthogonal array, the effects of wall thickness (2, 4, and 6 mm) and cut-out parameters...

Awareness level of cancer risk factors and warning signs among adults in Mansoura District, Egypt

BACKGROUND: Cancer remains a leading cause of mortality worldwide, with prevention and early detection dependent on the public awareness of its risk factors and warning signs. However, knowledge of cancer-related symptoms and modifiable risk factors remains limited in many popula...

Mixed Cropping Improves Soil Fertility via Enhancing Plant Facilitation in Alpine Artificial Grassland

By enhancing plant complementarity and facilitation, mixed cropping may accelerate soil fertility recovery and improve grassland ecosystem resilience. Nevertheless, the impacts of mixed cropping on soil fertility over a single growing season, and the underlying plant–soil interac...

Effects of Ad Libitum Feeding and Arginine Supplementation on Growth of Piglets and Reproductive Performance Parameters of Sows

The study evaluated the effects of ad libitum feeding with or without L-arginine (Arg) supplementation during lactation on sow performance, piglet growth, and sow backfat thickness. Seventy-one sows were assigned to three dietary treatments: restricted feeding without Arg supplem...

Subcutaneous onlay laparoscopic approach (SCOLA) for ventral hernia with concomitant diastasis recti: a single-center experience

Abstract Background Despite advances in hernia repair techniques, high recurrence rates remain a major challenge; studies report rates as high as 31.2% when DR is not addressed. Diastasis recti (DR) raises the risk of hernia recurrence after midline ventral hernia repair. About 4...

Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma

Tumour-associated macrophages (TAMs) are known to promote tumour progression in many kinds of malignant tumour, including hepatoblastoma (HB). Based on previous studies, we suggested that TAM-mediated sex-determining region Y-box 9 (SOX9) signal might enhance HB progression. The...

Role of arterial spin labelling in the assessment of brain tumours and tumour-like lesions: a case-based review

Abstract Arterial spin labelling (ASL) is one of the new cerebral perfusion magnetic resonance imaging (MRI) studies that provides useful information about the intracranial lesional perfusion through the measurement of cerebral blood flow (CBF). Tumours and tumour-like lesions ar...

Modeling Canine Hemangiosarcoma Progression Using Patient-Derived 2.5D Organoids and Orthotopic Xenografts

Canine hemangiosarcoma (HSA) is a highly aggressive vascular malignancy encountered in veterinary practice and exhibits histopathological and molecular similarities to human angiosarcoma (AS). Despite its clinical importance, the molecular mechanisms driving canine HSA remain poo...

Safety and efficacy of ertugliflozin on heart failure outcomes across cardiovascular diseases: a systematic review and meta-analysis

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) improve cardiovascular outcomes in patients with heart failure (HF) and type 2 diabetes (T2D). However, the efficacy of individual SGLT2is, particularly ertugliflozin, remains less defined. This systematic review and meta-analys...

The link between negative workplace gossip and employee creativity in healthcare organizations – a moderated mediation model

Purpose This study aims to investigate how negative workplace gossip (NWG), defined as informal and critical talk about absent colleagues, reduces employee creativity in healthcare organizations. Drawing on social cognitive theory (SCT) and self-determination theory (SDT), the st...

Palynology of Bathonian macroflora-bearing beds from NW-Jordan – expanding a rare ‘peephole’ into Middle Jurassic palaeotropical vegetation

Abstract A diverse and well-preserved sporomorph assemblage was recovered from the Middle Jurassic (Bathonian) marine Arda Formation in Jordan. The recorded palynomorphs originated from macroflora-rich layers that primarily represent a bennettitalean-fern community. This finding...

Metaheuristic-Based PI Controller Tuning Using a Multi-Error ITAE Objective Function for FOC-Controlled PMSM Drives in Electric Vehicle Applications

Permanent Magnet Synchronous Motors (PMSMs) are widely employed in electric vehicle (EV) propulsion systems because of their high efficiency, high power density, and superior dynamic performance. The performance of field-oriented control (FOC)-based PMSM drives strongly depends o...

Earthquake magnitude estimation using an optimized CNN-DNN-GRU model with binary differential evolution and firefly algorithm

Accurate earthquake magnitude estimation is critical for mitigating seismic hazards; however, the inherently nonlinear and dynamic characteristics of geophysical data present persistent modeling challenges. To address this complexity, this study proposes a novel hybrid deep learn...

Carcinogenic and non-carcinogenic health risks associated with heavy metal exposure in commonly consumed marine fish in Egypt

Abstract This study aimed to quantify the levels of mercury (Hg), arsenic (As), lead (Pb), and cadmium (Cd) in 250 fish samples, including flathead grey mullet, sardine, and mackerel, collected from local fish markets in Mansoura, Egypt, on ten occasions from August 2023 to March...