Lomonosov Moscow State University

Peptide language pragmatic analysis and two-stage hierarchical learning framework for therapeutic peptide prediction

Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues an...

Conformal blocks of Wess-Zumino-Witten model from its free-field representation

A bstract A powerful approach to the celebrated Wess-Zumino-Witten (WZW) model is provided by its free-field realization. However, explicit calculations of conformal blocks are not described in the literature in full detail. We begin this study with the simplest cases of the $$ \...

Role of Nickel Migration from Carbon Nanofibers Support to Active Phase in Tuning MoS2 Catalysts for Syngas Conversion to Higher Alcohols

Abstract The role of nickel migration from carbon nanofiber (CNF) supports to the active MoS2 phase was systematically investigated for higher alcohol synthesis (HAS) from syngas. A series of K-promoted MoS2 catalysts with varying nickel loadings (0–5 wt %) was prepared on CNF su...

Species of the Genus ×Agrotrigia (Hordeeae, Poaceae)—A Case of a Different Pattern of Parental rDNA Elimination

All taxa of plants have undergone several rounds of whole-genome duplication (WGD), accompanying interspecific and intergeneric crosses; subsequently, some part of one or both parent genomes in hybrid plants can be eliminated. The objective of this study was to evaluate the relat...

Linker Engineering of Hybrid Triazole-Thiazolidine Antifungals Identifies a Promising Lead Against Drug-Resistant Candida Species

Background: The emergence of antifungal resistance and the limited number of clinically available antifungal drug classes necessitate the development of new agents with improved efficacy and safety. We investigated how linker architecture influences the antifungal activity and le...

Protocol to generate human T cell progenitors that repopulate the thymus

Human pluripotent stem cells (hPSCs) provide a powerful platform for generating T cell progenitors and investigating hematopoietic stem cell (HSC)-independent T cell development. Here, we present a protocol for the directed differentiation of hPSCs to generate early progenitors o...

Managing the Transition to an Economy of Freely Chosen Activity under Pervasive General-Purpose Robotic Automation: A Mathematical and Agent-Based Policy Model with a Critical Review of the Literature

We develop a national-level decision-support framework for managing a long-run transition to an economy in which artificial intelligence and inexpensive general-purpose robots can perform a substantial share of cognitive and physical tasks. The framework does not forecast the tec...

Neuroinflammatory Response to Postnatal Administration of Valproic Acid in Wistar Rats as a Mechanism for the Development of Autism Spectrum Disorders: The Role of Neutrophils

Background/Objectives: According to current concepts, neuroinflammation is one of the putative causes of autism spectrum disorders (ASD) development. However, the role of neutrophils in neuroinflammation remains insufficiently studied. The study was aimed to determine the role of...

Beyond majority voting: a new framework for evaluating AI diagnostic systems against expert consensus

The integration of artificial intelligence (AI) into medical diagnostic workflows requires robust and consistent evaluation methods to ensure reliability, clinical relevance, and the inherent variability in expert judgments. Traditional metrics like precision and recall often fai...