La Trobe University

Australian Cat Owners Want a Calm Cat Who Stays at Home: The Ideal Cat Study

Dogs have historically been favoured in research efforts focused on optimising human–pet relationships, even though cats are also commonly kept as pets. Research has previously established Australians’ preferences for companion dog characteristics, revealing which characteristics...

Lipidomic Profiling of Milk Enables Identification of Novel Biomarkers for Subclinical Ketosis in Dairy Cows

The current clinical test for ketosis in dairy cows, which is based on measuring blood β-hydroxybutyrate (BHB) concentrations, is an invasive procedure that impacts herd welfare. Alternative biomarkers, especially non-invasive ones, are urgently needed for subclinical ketosis (SC...

The use of natriuretic peptide to screen for stage B heart failure based on echocardiogram among cancer survivors

Abstract Background and Aims Heart failure is a progressive disorder that can be identified at earlier stage, also known as stage B heart failure (SBHF). While N-terminal pro-B-type natriuretic peptide (NT-proBNP) was shown to be a key biomarker, its screening performance among c...

Coronary Plaque Burden and Plaque Composition in Long-Term Cancer Survivors: A Comparative CCTA Study

Abstract Background The increased risk of atherosclerotic cardiovascular disease in cancer survivors is not fully elucidated. Understanding the coronary plaque burden and composition in survivors could address this gap. Objectives To determine whether cancer survivorship is assoc...

Midwifery leaders’ views of the barriers and facilitators for implementing, sustaining and upscaling midwife-led continuity of care in Australia – a qualitative study

Problem Despite national and global recommendations, most pregnant women in Australia do not receive midwife-led continuity of care (MLCoC). Background MLCoC improves health outcomes, yet its implementation has been slow. Supportive leadership is essential for upscaling, and insi...

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD‐208 via Lysosomal Rerouting of CD63+ Compartments

ABSTRACT Pharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF‐β receptor I) inhibitor SD‐208 as a potent suppressor of small EV (sEV) secretion that acts independently of its canonical anti‐fibrotic activit...

Building effective leadership and coordination for assistive technology: best practices and recommendations from six countries across Sub-Saharan Africa

BACKGROUND: Effective leadership and coordination are essential for improving access to assistive technology (AT), particularly in low- and middle-income countries where efforts are often fragmented and resources limited, posing significant challenges. This study examines best pr...

Indicators of academic success among primary EAL learners: a qualitative systematic review

English an Additional Language (EAL) learner success is often narrowly defined by academic testing. However, there are diverse perspectives on what constitutes success, especially when viewed from the perspectives of learners, parents and teachers. As a result, this qualitative s...

Secondary school teachers' roles and experiences in supporting students with depression, anxiety, early psychosis, and suicide risk: A scoping review

Mental ill health commonly emerges during adolescence, with depression and anxiety highly prevalent, early psychosis first appearing during this period, and suicide a leading cause of death among young people. These conditions disrupt students' engagement, attendance, and academi...

"I am not that trauma": recognition of and response to domestic and family violence mental health presentations among South Asian migrant and refugee women in primary care in Melbourne, Australia

Domestic and family violence (DFV) is a major driver of mental health distress among women. Despite the growing population of migrant and refugee women in Australia, there is limited understanding of how they engage with, access or are supported by Australia’s mental health care...

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is mos...

Health, Legal and Security Costs Associated with Improved Safety from Family Violence During Family Court Involvement

Abstract Purpose Parent separation involving litigation and concurrent family violence (FV) risks is costly on many fronts. Costs borne by society toward improved safety from FV are essential and associated public policy should be well targeted. This study examined legal, safety,...

P1.153. Dietitian-Led Integration of CT Body Composition Analysis in Oesophagogastric Cancer Care

Abstract Topic Esophageal Cancer: Other Background Malnutrition and poor muscle health are prevalent in patients with oesophagogastric cancer and are associated with poor outcomes. However, body composition assessment is not routinely implemented in clinical practice. This projec...

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target to...

Digital infrastructure and readiness for artificial intelligence (AI) - enabled dentistry: technology adoption and barriers among dental practitioners in Bengaluru, India

To assess digital readiness for AI-enabled dentistry by evaluating the uptake of digital technologies, patterns of use, and implementation barriers among dentists in Bengaluru, India. A cross-sectional survey was conducted among 138 practising dentists using quota-based purposive...

Novel chimeric PD-L1::PD-L2 fusion and immune evasion in lymphoma

We report a novel in-frame CD274::PDCD1LG2 fusion in primary mediastinal B-cell lymphoma. Functional studies using expression constructs and CRISPR-engineered lymphoma cells confirmed formation of a PD-L1::PD-L2 chimeric protein and marked upregulation of PD-L1 surface expression...

Using Machine Learning to Predict Corporate Environmental Violation: A Stakeholder Pressure Perspective

ABSTRACT Predicting corporate environmental violations remains a key challenge in practice and in environmental governance research. However, existing studies have largely focused on ex post associations between stakeholder pressures and realized environmental violations, offerin...

Anxiety and mood disorders from childhood to adulthood in very preterm and term-born individuals

BACKGROUND: Very preterm (VP) birth has been associated with higher rates of anxiety and mood disorders, but the emergence and persistence from childhood to adulthood is unknown. This study examined prevalence rates and early risk factors of these disorders in VP and term-born in...

Ankle muscle strength, joint hypermobility, and foot posture in children aged 5–10 years: A cross-sectional study

Abstract During childhood, foot posture, joint hypermobility, and foot and ankle strength may influence lower limb function. However, there is limited evidence analysing these variables together in the paediatric population. The study aims to analyse how foot posture, joint hyper...

Stäckel transform, coupling constant metamorphosis and algebraization of quasi-exactly solvable systems

Abstract We extend the application of the notions of the Stäckel transform and the coupling constant metamorphosis to quasi-exactly solvable systems. We discover that for a variety of one-dimensional and separable multidimensional quasi-exactly solvable systems, their sl (2) alge...