La Trobe University

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target to...

P1.153. Dietitian-Led Integration of CT Body Composition Analysis in Oesophagogastric Cancer Care

Abstract Topic Esophageal Cancer: Other Background Malnutrition and poor muscle health are prevalent in patients with oesophagogastric cancer and are associated with poor outcomes. However, body composition assessment is not routinely implemented in clinical practice. This projec...

Digital infrastructure and readiness for artificial intelligence (AI) - enabled dentistry: technology adoption and barriers among dental practitioners in Bengaluru, India

To assess digital readiness for AI-enabled dentistry by evaluating the uptake of digital technologies, patterns of use, and implementation barriers among dentists in Bengaluru, India. A cross-sectional survey was conducted among 138 practising dentists using quota-based purposive...

Novel chimeric PD-L1::PD-L2 fusion and immune evasion in lymphoma

We report a novel in-frame CD274::PDCD1LG2 fusion in primary mediastinal B-cell lymphoma. Functional studies using expression constructs and CRISPR-engineered lymphoma cells confirmed formation of a PD-L1::PD-L2 chimeric protein and marked upregulation of PD-L1 surface expression...

Using Machine Learning to Predict Corporate Environmental Violation: A Stakeholder Pressure Perspective

ABSTRACT Predicting corporate environmental violations remains a key challenge in practice and in environmental governance research. However, existing studies have largely focused on ex post associations between stakeholder pressures and realized environmental violations, offerin...

Ankle muscle strength, joint hypermobility, and foot posture in children aged 5–10 years: A cross-sectional study

Abstract During childhood, foot posture, joint hypermobility, and foot and ankle strength may influence lower limb function. However, there is limited evidence analysing these variables together in the paediatric population. The study aims to analyse how foot posture, joint hyper...

Anxiety and mood disorders from childhood to adulthood in very preterm and term-born individuals

BACKGROUND: Very preterm (VP) birth has been associated with higher rates of anxiety and mood disorders, but the emergence and persistence from childhood to adulthood is unknown. This study examined prevalence rates and early risk factors of these disorders in VP and term-born in...

Stäckel transform, coupling constant metamorphosis and algebraization of quasi-exactly solvable systems

Abstract We extend the application of the notions of the Stäckel transform and the coupling constant metamorphosis to quasi-exactly solvable systems. We discover that for a variety of one-dimensional and separable multidimensional quasi-exactly solvable systems, their sl (2) alge...

Co-designed development of a vocational education and training program for peer health and social care navigators in Australia

<title>Abstract</title> Background Peer health navigators (lay patient navigators) are increasingly used to support consumers to access and navigate health and social care systems, particularly for populations experiencing barriers to care. Despite growing evidence of their effec...

Aphasia treatment research: a decision-making tool to guide the design of phased trials from the Collaboration of Aphasia Trialists (CATs) trials for aphasia panel

Background Systematic reviews of randomised controlled trials with meta-analyses indicate that speech and language therapy for aphasia after stroke is effective in improving communication. However, high-quality evidence to identify an intervention’s target population (who), regim...

Subcultural desires: Attraction to twinks, jocks, and bears is associated with sexual preferences for specific body types, gender expressions, and racial groups

Sexual subcultures such as twinks, jocks, and bears have provided sexual minority men with a means of self-definition and social connection within a broader LGBTQIA+ community. The present study explores the preferences associated with attraction to these subcultures, shedding li...

Efficacy of Vitamin C Treatment to Aid the Healing of Foot Ulcers in People With Diabetes: A Randomised, Placebo‐Controlled Double‐Blind Trial: The FOOT‐C Study Protocol

ABSTRACT Introduction Diabetes‐related foot ulceration (DFU) is a serious complication, serving as a leading cause of amputation, disability, hospitalisation and a significant contributor to healthcare costs. Deficiencies in vitamin C and other micronutrients are common in DFU. E...

Health Care Stigma and HIV/Sexually Transmitted Infection Prevention Service Uptake Among Cisgender Men and Gender-Diverse Individuals Who Have Sex with Men in Five Asian Countries: Implications for Differentiated Service Delivery

Health care stigma remains a key barrier to HIV and sexually transmitted infection (STI) prevention, yet its effects may differ across health care systems. We examined associations between health care stigma and HIV/STI prevention service uptake across five Asian countries. A cro...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...

Prevalence and severity of pubic symphysis radiographic findings in male and female sub-elite football players with and without hip and/or groin pain

OBJECTIVE: To determine the prevalence and severity of radiographic features of the pubic symphysis in sub-elite football players (soccer and Australian football) with and without hip and/or groin pain, and to compare these features between men and women. MATERIALS AND METHODS: T...

Seed germination ecology of burning nettle ( Urtica urens ) and common groundsel ( Senecio vulgaris ) populations from leafy salad production systems in Australia

Abstract Burning nettle ( Urtica urens L.) and common groundsel ( Senecio vulgaris L.) are widespread, economically important weeds in horticultural systems. This laboratory and glasshouse study evaluated the effect of temperature, photoperiod, salinity, osmotic stress, and pH on...

Mediating Factors That Explain the Link Between Exposure to Alcohol Content on Social Media and Alcohol Use: A Systematic Review and Meta-Analysis

Despite evidence that there is a link between exposure to alcohol-related content on social media and alcohol use, there has been less focus on testing the underlying mechanisms that explain the link. Findings from the primary studies that test the mechanisms are fragmented and i...

Pollen source in Prasophyllum affects seed quantity and quality

Context Prasophyllum (Orchidaceae) contains 40 nationally threatened species in Australia, and the collection of viable seed is key to their conservation. However, knowledge of mating systems in Prasophyllum is limited, and the effects of pollen source (self, outcross, and natura...

Stability of Medicinal Nanoemulsions to Spaceflight: Insights From the StarMed Experiment

Space missions require liquid drug formulations that remain physically stable and exhibit predictable release under launch, microgravity, and handling stresses. This study examined melatonin‑loaded nanoemulsions flown on the MAPHEUS‑15 sounding rocket, comparing an uncoated nanoe...

Podiatry for preventing falls in older people in the community

OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of podiatry interventions for preventing falls in older people living in the community.