Kurume University

All‐Arthroscopic Rotator Cuff Muscle Advancement With Pan Scapular Release and Using the Scapular Triangular View

Abstract An all‐arthroscopic rotator cuff muscle advancement technique is presented for posterosuperior massive tears. This procedure involves subperiosteal release of the supraspinatus and infraspinatus from the scapula while preserving continuity with the levator scapulae and t...

Epistemological Anatomy: A Conceptual Framework for Understanding Anatomical Knowledge

Anatomy is often regarded as settled knowledge. Yet anatomical propositions differ enormously in their evidentiary foundations, while textbooks and atlases frequently present them with similar certainty. How, then, does an anatomical observation become anatomical knowledge? We in...

Delivery of cardiac rehabilitation through hybrid models and alternative settings by country income classification and decade: Comparisons from the International Council of Cardiovascular Prevention and Rehabilitation’s 2025 Global Audit Update

Objective Cardiac rehabilitation (CR) is an outpatient model of secondary prevention that improves patient outcomes, yet use remains limited. Hybrid/alternative CR addresses these challenges, but global availability, structure, and volumes have not been characterized since the pa...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

The Clinical Characteristics and Management of Dental-Related Foreign Body Accidents: A Retrospective Observational Study

Background: Dental-related foreign body accidents are uncommon but potentially serious iatrogenic complications. Although numerous case reports have been published, comprehensive clinical studies describing their clinical characteristics, management, and outcomes remain limited....

Long-Term Functional and Aesthetic Outcomes of Bilateral Tessier No. 7 Cleft With Associated Anomalies: A Case Report With 20-Year Follow-up

We report the long-term functional and aesthetic outcomes of a male patient with bilateral severe Tessier no. 7 clefts associated with mandibular hypoplasia, cleft palate, right soft-palate hypoplasia, and congenital bilateral facial nerve palsy. The patient required enteral nutr...

Person-Period survival models with time-dependent covariates: a comparative simulation and pharmacovigilance case study

Person-period data are widely used in time-to-event analyses with time-dependent covariates when covariate histories are summarized over discrete intervals. In pharmacovigilance databases, cumulative drug exposure often requires reconstruction from irregular dosing records, requi...

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

Abstract Background In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Methods Pat...

Assessment of fibrosing interstitial lung disease progression: CT visual score on radiological progressive pulmonary fibrosis criteria versus 3D-CT volume-histogram analysis

Abstract Purpose To identify the most reproducible visual scoring approach on radiological criteria of the 2022 progressive pulmonary fibrosis (PPF) guideline and compare its association with pulmonary function test (PFT) decline against quantitative 3D-CT volume-histogram analys...

Distinct fascicular and epineurial architecture of the obturator nerve: a comparative analysis with clinical and surgical relevance

Peripheral nerves of the lumbar plexus share a common origin but exhibit distinct anatomical and clinical features.Although the gross anatomy of these nerves has been described, differences in cross-sectional structure remain unclear.This study compared the histological architect...

Impact of Circumferential Calcification and Acquired Minimum Lumen Area on 1‐Year Primary Patency After Drug‐Coated Balloon Angioplasty for Femoropopliteal Lesions

BACKGROUND: Severe calcification predicts restenosis after drug-coated balloon (DCB) angioplasty for femoropopliteal lesions, but whether an adequate post-procedural minimum lumen area (MLA) can attenuate this effect, and how intravascular ultrasound (IVUS) circumferential calcif...

Bottom-Up Model Suggesting Membrane Localization of Heme Oxygenase-1 Contributes to Heme Selection for Degradation

Abstract Heme functions as a prosthetic group in numerous hemoproteins, whereas a fraction of intracellular heme is not tightly bound to proteins or membranes and can readily dissociate; this labile heme participates in the regulation of diverse cellular processes. Heme has pro-o...

Exploratory proteomic analysis of idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis using data-independent acquisition

Idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (fHP) are two distinct interstitial lung diseases often showing similar clinical features, making differentiation challenging. Precise diagnosis is essential because treatment strategies for these condi...

Evaluation of clinical prognostic factors for radium-223 therapy in castration-resistant prostate cancer with bone metastases: the KYUCOG-1901 study

We evaluated clinical factors associated with symptomatic skeletal events (SSEs), radiographic progression-free survival (rPFS), and overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) and bone metastases treated with radium-223 (Ra-223)...

Long-term effects of cognitive-behavioral therapy for adults with ADHD: results from an 8-year randomized controlled trial follow-up

Abstract Background To evaluate the provisional long-term durability of group cognitive behavioral therapy (CBT) benefits 8 years post-baseline and to explore tentative associations between digital booster engagement and the maintenance of treatment gains in adults with ADHD. Met...

Angioarchitectural characterization of transdural supply in brain arteriovenous malformations: a multicenter retrospective study

Transdural supply (TDS) is a recognized angioarchitectural feature of brain arteriovenous malformations (bAVMs). We aimed to systematically characterize the angioarchitecture of TDS in bAVMs, focusing on whether transdural feeders terminated within the nidus or connected directly...

Intermuscular Fusion Between the Psoas Major and Iliacus Muscles: Anatomical and Histological Study

Abstract Introduction The term iliopsoas has recently been questioned because some anatomical studies have revealed that the psoas major and iliacus have separate distal insertions. Additionally, some older references mention a more proximal intermuscular fusion. Therefore, the a...

Comparison of response criteria in palliative radiotherapy for bleeding gastric cancer: A secondary analysis of the JROSG 17-3 multicenter prospective observational study

PURPOSE: In radiotherapy for bleeding gastric cancer, no standard response definition exists; studies have used transfusion-only or transfusion-plus-hemoglobin criteria. After inter-facility transfer or during home care-sometimes following palliative radiotherapy-laboratory resul...

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

BACKGROUND: Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide m...

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

Abstract While nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard second-line regimen for unresectable pancreatic cancer (uPC) after gemcitabine-based therapy, the effects of initial dosing and relative dose intensity (RDI) in routine practice are unc...