KU Leuven

Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases

Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive over...

Intra-abdominal Bowel Dilation in Experimental Gastroschisis Is Associated With a Modifiable Transcriptomic Program of Intestinal Dysfunction

OBJECTIVE: To characterize intestinal transcriptional profiles in gastroschisis, their temporal evolution, and response to fetal intervention. SUMMARY BACKGROUND DATA: Gastroschisis causes significant intestinal dysfunction, with intra-abdominal bowel dilation clinically shown to...

Fluorescence-Gated Flow Cytometry Approach for Measuring Lipid Flippase Activity in Mammalian Cells

Abstract P4‑ATPase lipid flippases establish transbilayer lipid asymmetry in eukaryotic membranes, with increasing evidence indicating a role for interacting partners in regulating flippase activity. However, assessing interactor‑dependent effects on flippase activity in mammalia...

Soil health-based business models: perspectives and policy implications

Abstract. Soil health is foundational to ecological sustainability, economic productivity, and societal wellbeing. However, fragmented perspectives on what constitutes “healthy soil” hinder coherent policies and business models. This article addresses that gap by offering a value...

Leveling the Peak: Standard Waveforms for Consistent PA Benchmarking

This is a paper submitted for review that focuses on creating a set of standard signals to use in PA measurement. The paper reviews why such standard signals are needed. As a companion, we are releasing a github that has a set of signals that we have curated and will additionally...

Intraoperative Adverse Events in Robot-assisted Minimally Invasive Esophagectomy (RAMIE)

Objective: Assess the incidence and management of intraoperative adverse events (IAEs) during robot-assisted minimally invasive esophagectomy (RAMIE) and evaluate their impact on postoperative outcomes. Background: IAEs are an inherent component of surgical practice and owing to...

ENACT FCT Maps - September 2025 - February 2026

The ENACT FCT Maps 2026 (1) summarise the trends in the observations submitted to the ENACT structured knowledge base during the period September 2025 - February 2026. The maps are aligned to the four observatories of ENACT: Capabilities Observatory Technology Observatory Market...

ENACT FCT Maps - September 2025 - February 2026

The ENACT FCT Maps 2026 (1) summarise the trends in the observations submitted to the ENACT structured knowledge base during the period September 2025 - February 2026. The maps are aligned to the four observatories of ENACT: Capabilities Observatory Technology Observatory Market...

Warped Geometries of Segre–Veronese Manifolds

Abstract. Segre–Veronese manifolds are smooth submanifolds of tensors comprising the partially symmetric rank-1 tensors. We investigate a one-parameter family of warped geometries of Segre–Veronese manifolds which includes the standard Euclidean geometry. This parameter controls...

Putting Globus Into Context: Prevalence, Characteristics, and Overlap With Other Disorders of Gut‐Brain Interaction

OBJECTIVE: Globus is characterized by the sensation of a lump in the throat without dysphagia or underlying structural abnormality or major motility disorder. Reported prevalences vary considerably across studies. Globus has been linked to both heartburn and affective disorders....

In-situ visualisation of the micromechanical deformation of apple tissue using 4D X-ray computed tomography with digital volume correlation

Continuous X-ray computed tomography (XCT) combined with digital volume correlation (DVC) is presented to quantify internal three-dimensional strain and failure dynamics in apple cortex tissue during compression, revealing how the cellular microstructure governs its mechanical re...

Solution of Erdős problem # 443

In [1, p.88], Erdős and Graham posed the following problem:Let m and n be positive integers and consider the two sets {k(m−k):1≤k≤m2} and {l(n−l):1≤l≤n2}.Can one estimate the number of integers com...

LazyHMC: Hamiltonian Monte Carlo Simulation for Lazy, Infinite Dimensional Probabilistic Programs

Hamiltonian Monte Carlo (HMC) is a successful generic inference method in probabilistic programming, but in its ordinary formulation it needs gradients and finite-dimensional parameter spaces. In Haskell, lazy evaluation lets probabilistic programs express stochastic processes an...

Design of Stainless Steel Homogeneous and Hybrid I-Sections Exhibiting Strong Flange Behavior

Abstract Stainless steel built-up I-profile are frequently designed with webs significantly more slender than their flanges and greater material strength in the flanges in case of hybrid sections. Given the fundamental load case of pure compression or bending, the compressed flan...

Anatomy and Biomechanics of the Deltoid Ligament Complex in Healthy Ankles: Protocol for a Systematic Review and Meta‐Analysis

ABSTRACT Introduction Up to one in two individuals who have a history of an ankle injury will develop chronic ankle instability, which subsequently increases the risk of osteoarthritis development. Although lateral ankle ligament injuries are the most common, recent research show...

Sexuality in Kenya: A Media Framing and Content Analysis of The Nation and The Standard Newspapers

The 2014 and 2019 reproductive healthcare bills tabled in the Kenyan parliament were withdrawn amid tensions involving the state, cultural values, and religious ideologies, whose norms regarding sexuality shaped the national debate. Public discourse framed these bills as contradi...

Histological aging signatures for monitoring tissue-specific aging and disease

Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from 40 tissue types acro...

Experiences of insemination fraud: discovering and navigating unexpected and entangled connections

The increasing use of direct-to-consumer genetic testing revealed not only more, but also different types of insemination fraud worldwide, making research into the topic urgently needed. This study explores how donor-conceived people and parents experience insemination fraud and...

Delivering building demand flexibility for grid-interactive operation: from perception and cognition to decision, execution, and verification

As both buildings and power systems undergo rapid decarbonization, demand flexibility (DF) in buildings has emerged as a key enabler for renewable energy integration, grid reliability, energy resilience, and efficient and low carbon operation. By dynamically adjusting building en...

Improving Functional Oral Intake in Head and Neck Cancer Survivors with Chronic Radiation-Associated Dysphagia – The Multicenter Randomized Controlled HIT-CRAD Trial

This randomized controlled trial evaluated the efficacy of home-based treatment programs for chronic radiation associated dysphagia (CRAD) in head and neck cancer (HNC) patients, comparing high-volume strength training to combined strength-skill training with either real or sham...