Kindai University

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Post-traumatic stress disorder (PTSD) is a mental health disorder triggered by exposure to a traumatic event, which manifests with anguish, intrusive memories, and negative mood changes. So far, there is no efficient treatment for PTSD other than symptomatic palliative care. Howe...

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

The risk of not imaging: a three-scenario framework for justification

Abstract A recurring argument in radiological protection holds that the radiation risk of an imaging examination must be weighed against the clinical risk of not performing it. The argument is applied inconsistently, and evidence on that clinical risk remains sparse compared with...

Renal function–adjusted initial JAK inhibitor dosing and outcomes in rheumatoid arthritis: from the ANSWER cohort study

INTRODUCTION/OBJECTIVES: To evaluate clinical effectiveness and treatment persistence after renal function-guided reduced-dose initiation of Janus kinase inhibitors (JAKis) in rheumatoid arthritis (RA). METHOD: We analysed 368 adults initiating a JAKi in the ANSWER registry (2013...

Perioperative Durvalumab for Resectable NSCLC : Updated Outcomes for Japanese Patients in AEGEAN

ABSTRACT In the phase 3 AEGEAN study, perioperative durvalumab plus neoadjuvant chemotherapy significantly improved the primary endpoints of event‐free survival (EFS) and pathological complete response (pCR) in patients with resectable NSCLC versus neoadjuvant chemotherapy alone....

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

Abstract Background In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Methods Pat...

Assessment of fibrosing interstitial lung disease progression: CT visual score on radiological progressive pulmonary fibrosis criteria versus 3D-CT volume-histogram analysis

Abstract Purpose To identify the most reproducible visual scoring approach on radiological criteria of the 2022 progressive pulmonary fibrosis (PPF) guideline and compare its association with pulmonary function test (PFT) decline against quantitative 3D-CT volume-histogram analys...

Association Between Acute-Phase Occupational Therapy and Quality of Life at Hospital Discharge and 90 Days After Discharge

Background/Objectives: Early rehabilitation in critically ill patients has been associated with improved physical outcomes. However, evidence regarding the association between occupational therapy and quality of life (QOL) remains limited. This study examined the association betw...

Longitudinal comparison of serum creatinine, estimated glomerular filtration rate, and blood urea nitrogen-to-creatinine ratio after initiation of palbociclib or abemaciclib: A single-center retrospective study

Introduction Abemaciclib inhibits renal tubular creatinine secretion and can increase serum creatinine without a true reduction in glomerular filtration rate. Direct real-world comparisons with palbociclib using routinely available laboratory markers are limited. Methods We condu...

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

Impact of baseline renal function on the clinical outcomes and safety of adjuvant nivolumab in high-risk urothelial carcinoma: a multicenter retrospective real-world study

Abstract Background Adjuvant nivolumab prolongs disease-free survival (DFS) in patients with urothelial carcinoma (UC) after radical surgery; however, evidence in those with reduced baseline renal function is limited. We investigated the impact of baseline creatinine clearance (C...

Development of a prognostic model for elderly patients with metastatic clear cell renal cell carcinoma treated with first-line immuno-oncology combination therapy.

BACKGROUND: In the era of immuno-oncology (IO) combination therapy, prognostic tools for elderly patients with metastatic clear cell renal cell carcinoma (ccRCC) are lacking. This study aimed to identify prognostic factors in elderly patients and evaluate a novel risk model using...

Effects of different trawling time on freshness changes in icefish (Salangichthys microdon)

Abstract In icefish ( Salangichthys microdon ) fishing in Lake Kasumigaura, trawling time is approximately 2 h. However, keeping icefish in the nets for about 2 h during the summer high water temperatures may degrade their quality. Therefore, this study compared the quality chang...

Evaluation of clinical prognostic factors for radium-223 therapy in castration-resistant prostate cancer with bone metastases: the KYUCOG-1901 study

We evaluated clinical factors associated with symptomatic skeletal events (SSEs), radiographic progression-free survival (rPFS), and overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) and bone metastases treated with radium-223 (Ra-223)...

Integrated dataset of atmospheric bioaerosols over east Asia

Abstract. Bioaerosols are one of the main types of aerosols originating from the Earth's biosphere and are widely found in the atmosphere. They possess both biological attributes and aerosol characteristics, thereby exerting significant influences on climate, the environment, eco...

Neutron Source Localization Using Plate-Shaped Fast Neutron Detectors

To ensure nuclear security at major public events, portable detectors are essential for surveying wide areas and verifying the absence of nuclear and radioactive materials. Fast neutron detectors enable surveys for localizing neutron-emitting sources and nuclear materials over wi...

NAD+ metabolism influences TGF-β–associated transcriptional programs and the gut microbiota in murine models of colitis

NAD + metabolism plays an important role in maintaining cellular homeostasis and has been implicated in fibrosis-related diseases, including inflammatory bowel disease (IBD). However, the molecular and system-level mechanisms linking NAD + metabolism to fibrosis remain incomplete...

Evaluating the Short-Form Foreign Language Classroom Anxiety Scale in a Japanese university EFL context: internal-structure evidence and score-interpretation boundaries

Abstract Foreign language classroom anxiety remains a central construct in applied linguistics, but brief instruments require context-specific evidence before their scores are used for substantive interpretation. This study examined the eight-item Short-Form Foreign Language Clas...

Comprehensive Spectroscopic Elucidation of Atomically Dispersed FeN 4 Active Sites of Fe‐N‐C Electrocatalysts

ABSTRACT To gain insights into single‐atom active sites of iron, nitrogen‐doped carbon (Fe‐N‐C), we performed comprehensive element‐specific spectroscopies including Fe K ‐edge X‐ray absorption, 57 Fe Mössbauer, and Fe Kβ 1,3 and valence‐to‐core (VtC) X‐ray emission spectroscopy...

Hexagulation numbers: symmetry breaking on the gyroid surface

Abstract The regular arrangements of identical spheres on the gyroid surface have been investigated using Monte Carlo simulations of hard spheres undergoing the Alder transition. In our preceding study, we showed that these regular structures on saddle-shaped triply periodic mini...