Kindai University

NAD+ metabolism influences TGF-β–associated transcriptional programs and the gut microbiota in murine models of colitis

NAD + metabolism plays an important role in maintaining cellular homeostasis and has been implicated in fibrosis-related diseases, including inflammatory bowel disease (IBD). However, the molecular and system-level mechanisms linking NAD + metabolism to fibrosis remain incomplete...

Evaluating the Short-Form Foreign Language Classroom Anxiety Scale in a Japanese university EFL context: internal-structure evidence and score-interpretation boundaries

Abstract Foreign language classroom anxiety remains a central construct in applied linguistics, but brief instruments require context-specific evidence before their scores are used for substantive interpretation. This study examined the eight-item Short-Form Foreign Language Clas...

Comprehensive Spectroscopic Elucidation of Atomically Dispersed FeN 4 Active Sites of Fe‐N‐C Electrocatalysts

ABSTRACT To gain insights into single‐atom active sites of iron, nitrogen‐doped carbon (Fe‐N‐C), we performed comprehensive element‐specific spectroscopies including Fe K ‐edge X‐ray absorption, 57 Fe Mössbauer, and Fe Kβ 1,3 and valence‐to‐core (VtC) X‐ray emission spectroscopy...

Hexagulation numbers: symmetry breaking on the gyroid surface

Abstract The regular arrangements of identical spheres on the gyroid surface have been investigated using Monte Carlo simulations of hard spheres undergoing the Alder transition. In our preceding study, we showed that these regular structures on saddle-shaped triply periodic mini...

Nivolumab plus ipilimumab-based treatment in Japanese patients with metastatic non-small cell lung cancer and tumor PD-L1 < 1%: a pooled analysis

BACKGROUND: Nivolumab plus ipilimumab-based therapies have shown long-term, durable clinical benefit in patients with metastatic non-small cell lung cancer (NSCLC), including those with tumor programmed death-ligand 1 (PD-L1) expression < 1%, a population with high unmet need. He...

Visualizing diagnosis-associated AMPA receptor-related [11C]K-2 PET SUVR patterns across psychiatric disorders using weakly supervised UMAP

AMPA receptors (AMPARs) mediate fast excitatory neurotransmission and play a central role in synaptic function, with accumulating evidence in psychiatric disorders. Using [ 11 C]K-2 PET to assess AMPAR-related signals in vivo, we examined whether regional standardized uptake valu...

Antioxidant, Anti-Inflammatory, and Bone-Remodeling Modulatory Activities of Thai Pigmented and Non-Pigmented Rice Bran Oils Containing Tocols and γ-Oryzanol

Rice bran oil (RBO) is a rich source of lipophilic bioactive compounds that may contribute to antioxidant, anti-inflammatory, and bone-health-promoting activities. This study investigated the effects of RBOs containing tocopherols, tocotrienols, and γ-oryzanol derived from Thai p...

Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress

Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce lethal oxidative stress and ferroptosis...

Clinical Impact of Gleason Pattern 5 on Doublet Versus Triplet Therapy in Metastatic Hormone‐Sensitive Prostate Cancer

BACKGROUND: Upfront treatment intensification with androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor has become a standard approach for metastatic hormone-sensitive prostate cancer (mHSPC). However, prognosis remains poor for some patients despite sec...

Interpretable machine learning for groundwater-level prediction incorporating pumping-well power consumption

Groundwater-level forecasting is essential for adaptive groundwater management in regions where pumping pressure and climatic variability interact, yet direct abstraction records are often unavailable. This study developed an interpretable extreme gradient boosting (XGB) framewor...