Kindai University

Nivolumab plus ipilimumab-based treatment in Japanese patients with metastatic non-small cell lung cancer and tumor PD-L1 < 1%: a pooled analysis

BACKGROUND: Nivolumab plus ipilimumab-based therapies have shown long-term, durable clinical benefit in patients with metastatic non-small cell lung cancer (NSCLC), including those with tumor programmed death-ligand 1 (PD-L1) expression < 1%, a population with high unmet need. He...

Visualizing diagnosis-associated AMPA receptor-related [11C]K-2 PET SUVR patterns across psychiatric disorders using weakly supervised UMAP

AMPA receptors (AMPARs) mediate fast excitatory neurotransmission and play a central role in synaptic function, with accumulating evidence in psychiatric disorders. Using [ 11 C]K-2 PET to assess AMPAR-related signals in vivo, we examined whether regional standardized uptake valu...

Antioxidant, Anti-Inflammatory, and Bone-Remodeling Modulatory Activities of Thai Pigmented and Non-Pigmented Rice Bran Oils Containing Tocols and γ-Oryzanol

Rice bran oil (RBO) is a rich source of lipophilic bioactive compounds that may contribute to antioxidant, anti-inflammatory, and bone-health-promoting activities. This study investigated the effects of RBOs containing tocopherols, tocotrienols, and γ-oryzanol derived from Thai p...

Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress

Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce lethal oxidative stress and ferroptosis...

Interpretable machine learning for groundwater-level prediction incorporating pumping-well power consumption

Groundwater-level forecasting is essential for adaptive groundwater management in regions where pumping pressure and climatic variability interact, yet direct abstraction records are often unavailable. This study developed an interpretable extreme gradient boosting (XGB) framewor...

Clinical Impact of Gleason Pattern 5 on Doublet Versus Triplet Therapy in Metastatic Hormone‐Sensitive Prostate Cancer

BACKGROUND: Upfront treatment intensification with androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor has become a standard approach for metastatic hormone-sensitive prostate cancer (mHSPC). However, prognosis remains poor for some patients despite sec...