Kanazawa University

Social networks, loneliness, purpose in life, and psychological distress after the 2024 Noto Peninsula earthquake: a community-based cross-sectional survey and structural equation modeling study

Post-disaster psychological distress may be shaped not only by acute disaster exposure but also by evolving recovery-related and psychosocial conditions. This study examined factors associated with serious psychological distress (SPD) and the interrelationships between social net...

Meningioma enlargement associated with luteinizing hormone-releasing hormone agonist therapy: two cases and supporting in vitro evidence

Abstract Luteinizing hormone-releasing hormone (LHRH) agonists are widely used for androgen-deprivation therapy in prostate cancer. Recent reports have raised concern that LHRH may influence the biological behavior of LHRH receptor-expressing intracranial tumors, including mening...

Malignant potential of intraductal papillary mucinous neoplasm (IPMN) of the pancreas: imaging assessment of IPMN-derived cancer and concomitant pancreatic ductal adenocarcinoma

Abstract The detection of pancreatic cystic lesions (PCLs) has increased markedly with the widespread use of cross-sectional imaging. Although the true proportion of intraductal papillary mucinous neoplasms (IPMNs) among PCLs remains uncertain, IPMN is considered to account for m...

Variational autoencoders can detect coronary artery disease in myocardial perfusion SPECT images

Abstract Purpose Variational autoencoders (VAEs) can detect unsupervised anomalies in medical images. We aimed to determine whether a VAE could automatically detect anomalies in myocardial perfusion SPECT (MPS) images. We then interpreted the training and generative processes of...

Real-world long-term continuation of lecanemab therapy and the clinical utility of phosphorylated tau 181

This real-world study evaluated the long-term feasibility of lecanemab treatment in 117 patients with early Alzheimer's disease at Kanazawa University Hospital. To assess treatment persistence over a full 18-month course, we focused on the 64 patients who initiated treatment betw...

Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma

Tumour-associated macrophages (TAMs) are known to promote tumour progression in many kinds of malignant tumour, including hepatoblastoma (HB). Based on previous studies, we suggested that TAM-mediated sex-determining region Y-box 9 (SOX9) signal might enhance HB progression. The...

Parkinsonism-like delayed neurotoxicity after idecabtagene vicleucel therapy for multiple myeloma: clinicopathological, cerebrospinal fluid, and autopsy analyses

Not available.

A dynamic framework for marine radioactivity baselines: Climate-driven variability of 137Cs in the Pacific Ocean

Radiocesium-137 ( 137 Cs) is a useful tracer of ocean circulation because of its long physical half-life and relatively conservative behavior in seawater. We investigated variability in Pacific 137 Cs concentrations and apparent half-lives using observational datasets and numeric...

Circadian temperature compensation is intrinsically linked with metabolism and redox signaling

Abstract Circadian rhythms are a universal property of organisms, and a defining property of these oscillators is the ability to maintain a precise period at different temperatures. Indeed, the discovery in the 1950s of this property, known as “temperature compensation,” was a wa...

Real-Space Imaging and Topological Indices of Finite Skyrmion Systems

We investigated the topological properties of finite skyrmion systems under open boundary conditions using a tight-binding model. To characterize topological order in finite systems without translational symmetry, we evaluated the local Chern marker (LCM) [Formula: see text], whi...

Working conditions, career barriers and perceived equity among neuro-oncology professionals: insights from the Japan society for neuro-oncology (JSNO) gender equality and diversity committee survey

<title>Abstract</title> Background Gender equity, work–life balance, and career development have become important concerns in the medical profession. However, empirical evidence on how neuro-oncology professionals experience working conditions, career barriers, and perceived ineq...

Comparative Analysis of Ion and Electron Contributions to Ionospheric Ionization at Auroral and Subauroral Latitudes

Abstract Electron and proton precipitation into the nightside ionosphere is a key process in magnetosphere–ionosphere coupling. Although auroral electron precipitation at –10 keV is traditionally considered the main driver of auroral emissions, recent studies show that keV electr...

Phase transition in a long-memory log-Gaussian Cox process

We study a stochastic point process with power-law temporal correlations driven by hidden variables. We show that a generalized Merton type model under an exponential-tail asset assumption—obtained by replacing the Gaussian cumulative distribution function with a logistic CDF— to...

Nanoscale Transdermal Drug Delivery Systems for Osteoarthritis: Strategies to Overcome the Skin Barrier

Abstract Osteoarthritis (OA) is a long-term degenerative common complaint characterized by increasingjoint dysfunction, synovial inflammation, and cartilage degradation. While traditionaltherapies, such as oral non-steroidal anti-inflammatory medicines (NSAIDs) and intra-articula...

Supramolecular Polymerization and Morphological Transformation of Dynamic Helical Poly(Phenylacetylene)s via Chain‐End Host–Guest Interactions

ABSTRACT Integration of dynamic helical polymers with supramolecular polymerization offers a promising strategy for constructing adaptive hierarchical chiral materials. However, the transformation of molecular‐level conformational changes in dynamic helical polymers into structur...

Effects of Three Assertion Training Sessions on Schoolchildren’s Assertiveness and Mental Health

As a crucial period for self and identity development, early adolescence may give rise to emotional issues due to inadequate methods of self-expression. Therefore, the development of self-expression during early adolescence may play a significant role in interpersonal relationshi...

Electrochemical Imaging of Hydrogen Evolution Reaction Sites at Transition Metal Dichalcogenide Nanosheets

Understanding spatial heterogeneity in catalytic activity is essential for designing efficient hydrogen evolution reaction (HER) catalysts. In this study, scanning electrochemical cell microscopy (SECCM) was employed to directly image local HER activity on transition metal dichal...

DNA methylation changes following rapid maxillary expansion in children

Rapid maxillary expansion (RME) is a widely used orthodontic intervention for correcting transverse maxillary deficiencies. By mechanically separating the midpalatal suture, RME improves occlusal relationships and induces tissue repair processes similar to fracture healing. Infla...

Indoleamine 2,3‐Dioxygenase 1 as an Adjunctive Histopathological Marker of Cholangitis Activity in Primary Biliary Cholangitis

ABSTRACT Aim To investigate the expression and clinicopathological significance of indoleamine 2,3‐dioxygenase 1 (IDO‐1) in primary biliary cholangitis (PBC), particularly its potential role as an adjunctive histopathological marker for diagnosis in early or atypical cases and as...

Intraspecies genetic diversity and host-associated distribution of Endolimax nana in Sumba Island, Indonesia

Endolimax nana is a common intestinal archamoebid within Evosea (Amoebozoa), alongside genera such as Entamoeba , Iodamoeba , and Mastigamoeba . Despite its frequent colonization of humans, it has received limited attention as a presumed non-pathogenic commensal, and its genetic...