Kamuzu Central Hospital

HIV and Antiretroviral Therapy Influence Tumor Microenvironment Architecture, Subclonal Evolution, and Immune Evasion Strategies in Diffuse Large B-Cell Lymphoma

The tumor immune microenvironment (TIME) and tumor heterogeneity shape prognosis and therapeutic response in Diffuse Large B-cell Lymphoma (DLBCL), but HIV-associated (HIV+) DLBCL remains poorly understood. To characterize the TIME and tumor-intrinsic features of DLBCL across a s...

A Cycle of Gendered Vulnerability: Understanding Violence, Poverty, and Systemic Failure Among Refugee Women in Malawi

Gender-based violence (GBV) is an urgent global health and social problem. GBV has implications for women's health outcomes and causes disruption to an individual's ecosystem, including their educational attainment, economic stability, and safety. Refugee women are an underserved...

A systematic review of ultrasound to predict severe disease in patients with dengue and other viral infections associated with hemorrhagic fevers

Background Viral infections associated with hemorrhagic fevers (VaHFs) cause millions of cases each year across a broad geography with severity ranging from asymptomatic cases to clinical disease with a high case fatality rate. Commonalities in pathophysiology across VaHFs includ...

Factors associated with paediatric ward abscondment in four district hospitals in Malawi

Abscondment from hospital poses risks to patients. The epidemiology of abscondment from hospitals remains unclear in Malawi and other sub-Saharan African settings. This case-control study used data from a hospital surveillance of the Malaria Vaccine Implementation Program in four...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Knowledge, attitude, and practice of antifungal resistance and stewardship among pharmacy students in Zambia: a cross-sectional study to inform antifungal stewardship programs

Background Antifungal resistance (AFR) is a growing global health threat, particularly in low- and middle-income countries such as Zambia, where antifungals are often accessed without prescription. Antifungal stewardship (AFS) programs aim to optimise antifungal use, yet limited...

Does plastic waste present an infection hazard? Current evidence, surveillance challenges and research priorities

Abstract Unmanaged plastic waste is widespread in settings with limited waste collection, yet its contribution to infectious disease risk remains poorly understood. In this review, we synthesise current evidence on the human health implications of plastic waste, with a specific f...

Association between the prevalence of overweight/obesity and dietary intake among mothers and children in urban and rural Malawi

Childhood and adult obesity are emerging public health concerns in sub-Saharan Africa, driven by rapid nutrition transition and changing food environments. To prevent the rising rate of childhood obesity and overweight/obesity among women in sub-Saharan Africa, and to understand...

Spatial patterns and factors associated with vaccination uptake at follow-up among previously identified zero-dose children in Mchinji District, Malawi

Globally, more than 14 million infants remained zero-dose in 2024, having not received the first dose of diphtheria-tetanus-pertussis-containing vaccine (DTP1). In Malawi, national immunisation estimates may mask sub-district inequities, limiting the ability to identify and reach...

The World Psychiatric Association (WPA) Guideline on Schizophrenia Spectrum Disorders Management for Low- and Middle-Income Countries

There is a pressing need to address the unique challenges of managing Schizophrenia Spectrum Disorders (SSD) in Low- and Middle-Income Countries (LMICs), where mental health resources are scarce and unevenly distributed. To develop this evidence-based guideline, we conducted a sy...