Justus-Liebig-Universität Gießen

The lung microbiome in childhood-onset severe neuromuscular disease with respiratory insufficiency: rationale, current evidence, and opportunities for oxford nanopore long-read sequencing

Abstract In severe childhood-onset neuromuscular disease (NMD), ventilatory muscle weakness and ineffective airway clearance drive recurrent infections and chronic colonization that is often culture-negative, polymicrobial, or both. The lung microbiome framework offers a unifying...

Snakebite Community Map Announcement: Find Research Groups, Clinicians & Organizations Worldwide

Snakebite envenoming remains a neglected tropical disease affecting millions of people annually, yet relevant expertise is scattered and complicated to identify. We introduce a community driven global map connecting researchers, clinicians and organizations across health, researc...

Snakebite Community Map Announcement: Find Research Groups, Clinicians & Organizations Worldwide

Snakebite envenoming remains a neglected tropical disease affecting millions of people annually, yet relevant expertise is scattered and complicated to identify. We introduce a community driven global map connecting researchers, clinicians and organizations across health, researc...

Neural responses during natural vision are action-timed rather than locked to the onset of stable foveal input

Visual processing is traditionally studied using static viewing paradigms in which researchers analyse brain responses to the onsets of a sequence of randomly selected stimuli. Translating this “stimulus onset” approach to active vision paradigms that allow for free eye-movements...

The added value of echocardiography in pulmonary arterial hypertension risk assessment an artificial intelligence machine learning–derived analysis of the ULTRA RIGHT VALUE registry

Abstract Aims The right ventricle (RV) is a major determinant of outcome in pulmonary arterial hypertension (PAH), but its assessment has not been completely incorporated in the risk of mortality scores. We therefore evaluated the added value of echocardiography of the RV to risk...

Scientific Competence in Undergraduate Medical Education: Professional Orientations of Physiology Educators

Introduction: Scientific Competence (SC) is a central objective in medical education, but its conceptualization remains insufficiently differentiated, particularly regarding the relationship between evidence use and participation in scientific knowledge generation. Objective: Thi...

Fates of residual nitrate under reductive soil disinfestation with different schemes

Intensive vegetable cultivation has caused severe nitrate (NO 3 − -N) accumulation and associated environmental issues. Reductive soil disinfestation (RSD), originally developed for suppressing soil-borne diseases, has proven effective in removing residual NO 3 − -N of topsoil at...

Cyclosporin A triggers a RIG-I-mediated interferon response through multiple cellular processes

Abstract The development of broad-spectrum antiviral agents is essential for preparedness against emerging viruses with pandemic potential. Cyclosporin A (CsA), a clinically approved immunosuppressant, has been shown to exert antiviral activity against a wide range of viruses. Re...

Tryptophan-driven metabolomic shift in Acidobacteriaceae reveals phytohormones and antifungal metabolites

ABSTRACT Acidobacteriota is one of the most abundant phyla in soils and has recently attracted attention for its potential role in promoting phytosanitary benefits. The metabolomic capabilities of this phylum remain poorly characterized, with few experimentally confirmed metaboli...

Vacuum ultraviolet dielectric function of cubic InGaN for the entire composition range

The cubic zincblende polymorph of InGaN is a very promising candidate for optical applications. Its absence of spontaneous polarization fields in the (001) orientation and lower fundamental band gap compared to its wurtzite counterpart makes it especially interesting for efficien...

A pathway towards decentralized studies of radioactive post-lead elements and their applications in beyond standard model physics

Abstract Molecules have proven to be sensitive tools for studying physics beyond the Standard Model, with heavy and deformed nuclei offering decisive sensitivity to parity- and time-reversal-violating effects. However, almost all elements beyond lead, occupying the 6p to 5f atomi...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Symbiont effectors modulate plant signalling to increase host stress resilience

Abstract Plant colonizing mutualistic symbionts confer beneficial effects to their hosts, which often includes increased growth, and biotic and abiotic stress resilience. How these benefits are activated on a molecular level is mostly unknown. Here, we describe effector candidate...

Optimizing efficacy to safety ratio of glucocorticoids in rheumatoid arthritis models by leveraging PPARα agonism

ABSTRACT Objectives Glucocorticoids remain essential therapies for several immune- and inflammatory diseases such as rheumatoid arthritis (RA) but are notorious for their (metabolic) side effects. Given the anti-inflammatory and metabolically favorable actions of peroxisome-proli...

TIS subsystems and modes of innovation: the case of hydrogen-powered aviation

Recent technological advancements in hydrogen-powered aviation are significantly influenced by start-up companies, despite substantial market entry barriers. To investigate the role of these emerging actors in the sustainability transition of the aviation sector, we compare the i...

Comparatively high genetic connectivity of red deer management units in Saxony-Anhalt within a standardized supraregional framework

Abstract Maintaining genetic connectivity is a central requirement for the long-term persistence of wide-ranging wildlife populations in increasingly human-modified landscapes. Population genetic approaches provide valuable tools for evaluating connectivity patterns and identifyi...

Identification of a nanosecond isomer of $$^{164}$$Tb

Abstract This letter reports on the identification of a new isomeric state of $$^{164}$$ 164 Tb ( $$Z=65$$ Z = 65 , $$N=99$$ N = 99 ), which was measured with the DESPEC setup at the GSI Helmholtzzentrum für Schwerionenforschung GmbH following the first relativistic fragmentation...

Hospital Length of Stay and Associated Factors in Patients with Oral Cavity Cancer in Germany: A Retrospective Multicenter Analysis of Inpatient Administrative Data

Background: Oral cavity cancer is a clinically relevant subgroup of head and neck malignancies and is associated with substantial treatment burden and healthcare utilization. Hospital length of stay (LOS) is an important indicator of inpatient resource use and complexity of care,...

Evaluating different roughness approaches and infiltration parameters for vegetation-influenced overland flow in hydrological model

Abstract. Accurately simulating overland flow in vegetated landscapes remains a challenge in hydrological modeling due to the complex interactions between vegetation, surface roughness, and soil infiltration. This study evaluates multiple methods for estimating Manning's roughnes...

Analyzing the interface properties of cubic GaN/AlN heterostructures using impedance spectroscopy

Cubic gallium nitride (c-GaN) is an attractive material system for various electronic and optoelectronic device applications, as it lacks internal piezoelectric polarization fields unlike its hexagonal counterpart. Yet, the fabrication of high-performing device structures depends...