Juntendo University

Total Synthesis of the Antifungal Clinical Candidate ASP2397 Cyclohexapeptide Facilitated by the Chemo-selective Reduction of Secondary N -Benzyloxyamides

Abstract ASP2397 is a siderophore-like cyclic hexapeptide with potent and rapid fungicidal activity against Aspergillus species. We report here its first total synthesis, enabled by an unprecedented one-pot chemoselective reduction of secondary N-benzyloxyamides that strictly pre...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

Sensory nerves regulate bone homeostasis in response to mechanical unloading or reloading: evidence from a spaceflight experiment and ground-based mechanical unloading models

Mechanical loading is crucial for maintaining bone mass, and understanding how bone remodels in response to mechanical loading is essential for treating musculoskeletal disorders. Recently, sensory nerves inside bone were identified as mechanical regulators of bone homeostasis. H...

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study ass...

Leveraging the salivary microbiome profile to stratify REM sleep behavior disorder and synucleinopathies

Abstract Few studies have explored noninvasive biomarkers of synucleinopathies, including Parkinson’s disease (PD), and rapid-eye-movement behavior disorder (RBD), a prodromal stage for these conditions. Human oral/salivary microbiomes are altered in PD, highlighting their potent...

Comparison of response criteria in palliative radiotherapy for bleeding gastric cancer: A secondary analysis of the JROSG 17-3 multicenter prospective observational study

PURPOSE: In radiotherapy for bleeding gastric cancer, no standard response definition exists; studies have used transfusion-only or transfusion-plus-hemoglobin criteria. After inter-facility transfer or during home care-sometimes following palliative radiotherapy-laboratory resul...

Cryo-EM structure of the bicarbonate receptor GPR30

G-protein-coupled receptor 30 (GPR30) is a bicarbonate receptor that plays a vital role in cellular responses to extracellular pH and ion homeostasis. Despite its significance, the mechanisms by which GPR30 interacts with bicarbonate ions remain elusive. There is no consensus on...

p62/ SQSTM1 : From an autophagy receptor to a condensate organizer of selective autophagy and stress signaling

Upon exposure to stress, cells activate a variety of stress-response and quality-control mechanisms to maintain homeostasis. Dysregulation of these processes is implicated in numerous diseases, including cancer, liver disorders, and neurodegenerative diseases. p62/Sequestosome 1...

Non-RA screening for systemic autoimmune rheumatic diseases using a machine learning model based on physical findings and blood test data

Abstract Background In patients with systemic autoimmune rheumatic diseases (SARDs), particularly patients with non-rheumatoid arthritis (non-RA), the incidence of severe conditions such as interstitial pneumonia and pulmonary arterial hypertension is high. Therefore, early refer...

Molecular genetics of skeletal muscle diseases associated with abnormal excitation–contraction coupling

Skeletal muscle excitation-contraction coupling (ECC) is a highly specialized process that converts membrane depolarization into contraction through tightly regulated intracellular Ca²⁺ dynamics. Recent advances in molecular genetics have expanded the spectrum of skeletal muscle...

Running Performance Decline in IRONMAN-Distance Triathlon: A Scoping Review of Existing Evidence and Research Gaps

In an IRONMAN-distance triathlon, run performance is a particularly strong correlate of overall race outcome, alongside cycling. Although individual research areas such as pacing, performance prediction, and laboratory physiology have been reviewed separately, they have not been...

Development of an interprofessional education program for aspiration pneumonia care: an action research study

INTRODUCTION/AIM: Aspiration pneumonia has evolved, with demographics shifting to predominantly frail older adults. However, despite the high healthcare impact, there is no established guideline or curriculum for the education and training of healthcare professionals in managing...

Muscle mechanical properties during voluntary contraction with motor-threshold neuromuscular electrical stimulation

Abstract Neuromuscular electrical stimulation (NMES) is often superimposed on voluntary contraction, but its effects on muscle mechanical properties remain unclear. We used shear wave elastography to assess the tibialis anterior at rest and during isometric ankle dorsiflexion wit...

Gut microbial and metabolic biomarkers for early-onset colorectal cancer

Early-onset colorectal cancer (EO-CRC) is a growing global health challenge with poorly understood etiology. While gut microbiota and metabolites are implicated in colorectal carcinogenesis, EO-CRC-associated signatures remain poorly characterized. This study presents the first l...

Hepatoprotective Effects of Imeglimin Are Associated With Preserved Mitochondrial Bioenergetics and Reduced Oxidative Stress in a Murine Cholestasis Model

PURPOSE: Biliary atresia is a cholestatic liver disease that causes persistent inflammation and reduces the hepatic reserve. New therapeutic concepts are crucial to improve native liver survival. We investigated whether imeglimin, a mitochondria-targeting agent, has hepatoprotect...

TREM2-LRP1 axis in Alzheimer's disease: pharmacological trade-offs of receptor shedding and functional restoration

Abstract The interplay between triggering receptor expressed on myeloid cells 2 (TREM2) and low-density lipoprotein receptor-related protein 1 (LRP1) is critical for amyloid-beta (Aβ) clearance in Alzheimer’s disease (AD). Current therapeutic strategies targeting this axis can be...

Serial ultrafine endoscopic assessment of fibrin deposition and neomembrane formation in peritoneal dialysis patients using low glucose degradation product fluid

Preservation of the peritoneum is essential for the safe continuation of peritoneal dialysis (PD). Although PD fluid with low glucose degradation products (low GDP) are widely used, objective macroscopic assessment of the peritoneum during ongoing PD remains limited. We therefore...

The association of corporate measures and health management initiatives with employee engagement in Japanese companies

Using data from 2,502 companies in Japan’s Health and Productivity Management Survey, this study examined determinants of employee engagement and corporate success. Regression analysis showed that hourly paid leave (adjusted odds ratio [aOR]: 1.29, 95% CI: 1.07–1.56) and communic...

An elementary form of agency at planetary-scale

Abstract The claim that climate homeorhesis—non-equilibrium steady-state dynamics that underlie Earth’s long-term habitability—depends on an integrated biosphere–climate system capable of acting on its own is central to debates surrounding the Gaia hypothesis. This paper presents...

Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress

Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce lethal oxidative stress and ferroptosis...