Johns Hopkins University Applied Physics Laboratory

A Hybrid Transfer Learning Approach for Ambient PM2.5 Exposure Modeling in LMIC Contexts: A Case Study from Lima, Peru

Abstract Exposure to fine particulate matter (PM2.5) contributes to millions of premature deaths annually worldwide. While epidemiological studies increasingly rely on geospatial technologies, such as satellite remote sensing, low-cost sensors, and chemical transport models, to q...

2-arm-PEG-OligocationsTransiently Shield theLiver Sinusoids to Mitigate Off-Target Hepatic Expression of mRNALipid Nanoparticles

ABSTRACT Ionizable lipid nanoparticles (iLNPs) are powerful platforms for mRNA-based vaccines and immunotherapies; however, their intrinsic liver tropism compromises both safety and efficacy. Off-target hepatic protein expression from delivered mRNA raises safety concerns, and he...

Wavelength Requirements for Life Detection via Reflected Light Spectroscopy of Rocky Exoplanets

Searching for signs of life is a primary goal of the Habitable Worlds Observatory (HWO). However, merely detecting oxygen, methane, or other widely discussed biosignatures is insufficient evidence for a biosphere. In parallel with biosignature detection, exoplanet life detection...

A Review ofAmmonia (NH3) Adsorption inPorous Solids

Abstract Ammonia (NH3) plays a crucial role in the agricultural sector as a fertilizer and is a dense hydrogen carrier that offers a potential renewable and carbon-free energy source. These significant advantages necessitate the development of efficient NH3 synthesis and separati...

Adapting in-cell ELISA to investigate the localization of hepatitis C virus envelope glycoproteins

The development of hepatitis C virus (HCV) vaccines remains challenging due to extensive viral genetic diversity and the complex biology of the envelope glycoproteins E1 and E2, which are major targets of broadly neutralizing antibodies and are associated with spontaneous viral c...

Conceptual System Design Case Study for Decision Analysis

As part of organizations pursuing innovation, systems engineering teams include experts in decision-driven data generation, analysis, and synthesis. These experts provide skill in crafting decision support models that show the relationship between decision alternatives and fundam...

Evaluating harvest risk with limited data: A case study on polar bears ( Ursus maritimus ) in East Greenland

Abstract Evaluating the impact of human‐caused removals on wildlife is challenging, especially when population data are limited, future monitoring is uncertain, and habitat conditions are changing. The East Greenland (EG) polar bear subpopulation contains 2275 animals (95% CI = 1...

Identificationof the Site of the Fe–S Clusterin CPSF30 via Metal-Coupled Oxidation-Mass Spectrometry

Abstract Cleavage and polyadenylation specificity factor 30 (CPSF30) is a zinc finger protein that plays a key role in pre-mRNA processing by recognizing specific AU-rich sequence elements to facilitate polyadenylation. CPSF30 contains five highly conserved domains made up of thr...