Jilin Medical University

Apigenin Alleviates Ligamentum Flavum Ossification by Dual-Targeting CA9 and CDK6 and Modulating Calcium/PI3K–Akt Signaling

While apigenin shows therapeutic potential for bone-related disorders like osteoporosis and osteoarthritis, its mechanisms in regulating ligamentum flavum ossification (OLF) are unclear. An integrated computational strategy combining network pharmacology, machine learning, and mo...

Accelerating theDiscovery of Deep-Ultraviolet NonlinearOptical Materials by Combining Machine Learning Interatomic Potentialswith First-Principles Calculations: A Case of LiB2O3F

Abstract Discovering deep-ultraviolet (deep-UV) nonlinear optical (NLO) crystals is hampered by the vast structural search space and the cost of first-principles screening. Here, we establish an integrated framework coupling machine learning interatomic potential (MLIP) construct...

Postsynthetic Zn(II)Species Modification Regulatesthe Surface States of TiO2 Nanoparticles for Resonance-AssistedSERS

Abstract Engineering interfacial electronic states at the nanoscale is a powerful yet underdeveloped strategy for improving the selectivity of semiconductor-based molecular sensing. Here, we report a simple postsynthetic surface-associated Zn(II) species modification approach to...

Spatiotemporal prediction of two-dimensional surface deformation in gas field incorporating MSBAS-InSAR and deep learning

Continuous extraction-induced deformation from oil and gas fields can trigger destructive geological hazards, significantly threatening underground infrastructure safety. Therefore, reliable surface deformation prediction is crucial for early warning of potential risks in oil and...

Ultra Broad Range Pressure Tunable CaZrO3:Ce3+ Luminescence for Multiparametric Manometry

Optical manometry is essential in diamond anvil cell experiments, motivating pressure-sensitive phosphors that provide robust broadband readouts over a wide pressure range. Here we report a Ce3+-activated CaZrO3 perovskite phosphor with a low dopant level of about 0.40 atom % Ce...

Bioinspired MXene-BasedFlexible and Degradable Membranesfor High-Performance Electromagnetic Shielding

Abstract Wearable shielding electronic skin is highly desirable for protecting humans from electromagnetic radiation. However, conventional wearable electromagnetic interference (EMI) shielding materials still encounter major challenges in simultaneously achieving high shielding...

Effect ofFracture Aperture and Water Saturation onthe In Situ Conversion of Tar-Rich Coal

Abstract With abundant coal resources globally, in situ conversion technology, an emerging unconventional energy development method, is a crucial pathway for achieving efficient and clean utilization of tar-rich coal. However, its application is challenged by the heterogeneity of...

Integrative network toxicology and computational modeling uncover the mechanism of aflatoxin B1-induced nephrotoxicity

Aflatoxin B1 (AFB1) is a highly toxic mycotoxin that causes severe renal injury, yet the molecular basis of its nephrotoxicity remains poorly defined. Here, we integrated multi-omics data with computational modeling to elucidate the mechanisms of AFB1-induced kidney damage. Three...

A configurational perspective of digital transformation: uncovering the multiple pathways to digital success in an emerging economy

Purpose Digital transformation (DT) research remains fragmented as prior studies adopt linear and factor-based approaches that overlook causal complexity. Drawing on the configurational theory and critical realism, this study addresses whether and how multiple organizational cond...

Targeting ARF6-SUCNR1 Axis: Antisense Oligonucleotide Adjuvants for Neutrophil Immunometabolism

Conventional vaccine adjuvants often lack cell-type specificity and readily trigger excessive systemic inflammation, limiting their clinical application. Immunometabolic signaling centered on the ARF6 (ADP-ribosylation factor 6)-SUCNR1 (Succinate receptor 1) axis governs neutroph...