Jilin Medical University

An Integrated Strategy for Decoding Bioactive Components and Mechanism of Jingtong Granules: Chemical Characterization, Network Analysis, Pharmacokinetic and Pharmacodynamic Studies

This study aimed to identify bioactive constituents of Jingtong Granules (JTG), a traditional Chinese medicine for cervical spondylotic radiculopathy (CSR), characterize their in vivo exposure, and explore pharmacological targets and pathways. Chemical constituents were character...

Antioxidant and Anti-Inflammatory Effects of Inhaled Ginkgo biloba Leaf Essential Oil in a Chronic Stress Mouse Model: Insights from Neuroimmune, Metabolic, and Gut Microbiota Remodeling

Chronic stress induces behavioral abnormalities through coordinated neuroendocrine, inflammatory, oxidative, metabolic, and gut microbial disturbances. Plant-derived volatile fractions may modulate stress-related neurobehavioral responses, yet their antioxidant and anti-inflammat...

Hedging without landing: domestic regulatory friction in Japan and South Korea caught between U.S. and EU digital mandates

Through a comparative institutional analysis of Japan and South Korea, this article examines whether middle powers can engage in hedging behaviour by simultaneously accommodating competing U.S. and EU digital mandates within their domestic legal orders. The article argues that du...

Unveiling the Synergistic Mechanism of Hardness and Toughness Enhancement in HPHT-Synthesized WAlB

Abstract Balancing hardness and toughness in ceramics to ensure reliable performance under extreme conditions remains a central and actively pursued research challenge. Recently, layered boride MAB phases have attracted increasing attention due to their excellent combination of m...

Reversible Information Encryption Based on Ag/TiO2 Hierarchical Plasmonic Structures

Abstract The escalating threat of information leakage necessitates the development of advanced, dynamic, and reversible encryption technologies beyond static optical encoding. Herein, we report a reversible information encryption platform based on Ag/TiO2 hierarchical plasmonic s...

Through-Space-Conjugated Viologen Cyclophanes for Single-Molecule Junctions

Abstract Molecular electronics offers a promising route toward device miniaturization beyond the limits of silicon-based technologies, but the rational design of molecular components with stable and tunable charge transport remains challenging. Through-space-conjugated (TSC) viol...

Rational Quantification of Deep Sodium Reversibility with a Utilization-Corrected N/P Descriptor toward Low-N/P-Ratio Solid-State Na–S Batteries

Abstract Solid-state Na–S batteries offer high energy density, yet their practicality deteriorates at low N/P ratios because limited Na inventory cannot compensate for irreversible loss. Under lean-Na conditions, the key issue is whether the restricted Na reservoir remains revers...

Self-Assembling Hole-Transport Molecules Enable Photomultiplication-Type Organic Photodetectors with High Detectivity and Enhanced Environmental Stability

Photomultiplication-type organic photodetectors (PM-OPDs) have attracted significant attention for their high gain and simplified device architecture. However, their practical application is severely constrained by the high dark current density inherent to charge injection-type m...

Zinc-Group Element-Stabilized Boron Analogues of Cyclopropenyl Cation Featuring π Aromaticity

Abstract Planar boron clusters often display π-bonding patterns analogous to those found in aromatic hydrocarbons, making them intriguing inorganic counterparts of classical hydrocarbon systems. Herein, we report zinc-group element-stabilized boron analogues of the cyclopropenyl...

A Bioinspired Random Nanosheet Film for Broadband Spectral Modulation and Switchable Infrared Stealth

Efficient spectral modulation and photothermal management can significantly enhance the multifunctional integration of intelligent optical devices. However, the selective modulation ability of materials to the spectrum hinders their application in different scenarios or needs. He...

Heteroepitaxial Growth of Single-Crystal Diamond on Amorphous Carbon under High Pressure and High Temperature

Abstract High-pressure and high-temperature (HPHT) heteroepitaxy enables diamond growth with dislocation densities approaching those of homoepitaxial crystals, yet the role of the amorphous carbon interlayer at the heterointerface remains poorly understood. Here, we investigate t...

Mechanochemical AlCl3-Catalyzed Cracking of Waste Polyolefins and Synthetic Rubbers into Liquid Fuel

Abstract Conventional recycling of polyolefins and rubbers is hindered by high energy consumption, complex processing, and limited substrate compatibility—fundamental barriers that have long impeded practical waste valorization. Here, we overcome these limitations with a mechanoc...

The enzyme inhibitory activity of helminth-derived serine protease inhibitor rapidly establishes immune tolerance to ameliorate allergic diseases

Allergic diseases are a class of important immune imbalance diseases that lack effective cures. Helminth-derived serine protease inhibitors (serpins) exert immunoregulatory effects similar to those of helminth, are controllable, have few side effects, and have great application p...

Enhanced Fog Harvesting via Synergistic Regulation of the Entire Process on a Multi-Bioinspired Patterned Surface

Freshwater scarcity has become an urgent global issue. Bioinspired fog harvesting is a promising route to freshwater supply, whereas conventional bioinspired surfaces merely optimize partial procedures independently, severely restricting fog harvesting efficiency. Herein, inspire...

A Charge Supplement Strategy Enhanced Non-contact Triboelectric Sensor for In Situ Blade Lift Monitoring of Unmanned Aerial Vehicles

Real-time monitoring of blade lift is critical for the flight stability and safety of unmanned aerial vehicles (UAVs); however, conventional electronic speed controller estimation methods exhibit limited accuracy, high hardware costs, and susceptibility to signal drift. To addres...

Hepatic toxicological and multi-omics alterations associated with short- and long-term nonylphenol exposure in mice

Nonylphenol (NP) is an alkylphenol environmental contaminant with endocrine-disrupting activity and potential hepatotoxicity. However, the molecular responses associated with different NP exposure durations remain insufficiently characterized. In this study, male Kunming mice wer...

Estimated glucose disposal rate and incident cardiovascular disease across ageing cohorts in China, England, and the United States: cross-national consistency and transportability

The estimated glucose disposal rate (eGDR), an insulin-resistance surrogate derived from routine clinical variables, has been associated with cardiovascular disease (CVD). We examined its association with incident CVD, cross-national transportability, and incremental discriminati...

Research on image fusion noise reduction method based on AFM scanned cell image in tapping

Abstract Scanning cells with Tapping-Mode Atomic Force Microscopy (TM-AFM) often introduces significant noise in the central region of the topography image, whereas the corresponding amplitude image remains relatively clear. Leveraging the strong correlation between these two ima...

Apigenin Alleviates Ligamentum Flavum Ossification by Dual-Targeting CA9 and CDK6 and Modulating Calcium/PI3K–Akt Signaling

While apigenin shows therapeutic potential for bone-related disorders like osteoporosis and osteoarthritis, its mechanisms in regulating ligamentum flavum ossification (OLF) are unclear. An integrated computational strategy combining network pharmacology, machine learning, and mo...

Accelerating theDiscovery of Deep-Ultraviolet NonlinearOptical Materials by Combining Machine Learning Interatomic Potentialswith First-Principles Calculations: A Case of LiB2O3F

Abstract Discovering deep-ultraviolet (deep-UV) nonlinear optical (NLO) crystals is hampered by the vast structural search space and the cost of first-principles screening. Here, we establish an integrated framework coupling machine learning interatomic potential (MLIP) construct...