Jichi Medical University

Dexmedetomidine attenuates methamphetamine-induced hyperthermia and hyperlocomotion in male rats and modulates monoamine dynamics in the anterior hypothalamus

Methamphetamine (METH) intoxication is associated with serious complications, including hyperthermia and agitation, which are major contributors to morbidity and mortality. Currently, no established pharmacological interventions are available for these conditions. To evaluate the...

Giant esophageal schwannoma mimicking a mediastinal tumor: a case report and review of the literature

Introduction: Esophageal schwannomas are rare, benign tumors arising from Schwann cells in the esophageal wall. Giant forms are particularly rare and can resemble mediastinal tumors, making preoperative diagnosis difficult. Case presentation: Herein, we present the case of a 55-y...

Impact of the modified Frailty Index-5 on treatment selection and prognosis in octogenarians with bladder cancer eligible for radical cystectomy: a single-center, retrospective study

<title>Abstract</title> Background Developing treatment strategies for bladder cancer in octogenarians remains challenging owing to concerns regarding surgical invasiveness and the risk of undertreatment. We aimed to evaluate the effect of the modified Frailty Index-5 score on tr...

Evaluation of lens parameters using anterior segment optical coherence tomography for zonular weakness risk in cataract surgery

<title>Abstract</title> Zonular weakness leads to deviation or dislocation of the crystalline lens; however, studies on this topic remain limited. We aimed to evaluate crystalline-lens parameters for risk stratification of zonular weakness in patients undergoing cataract surgery....

Effects of Dapagliflozin on the Bone of Patients with CKD on Dialysis

The effects of gliflozins on bones of CKD patients on dialysis are unknown. Recently, SGLT2 expression in bone tissue of patients with CKD has been reported. We hypothesized that dapagliflozin may act in bone cells and modulate the Klotho-FGF23 axis. This study analyzed the effec...

A novel method of manipulation and immobilization with the wrist dorsiflexed for distal radius fractures: short-term outcomes

Distal radius fractures (DRFs) are the most common fractures in adults. For displaced DRFs, casting after successful closed reduction remains a standard treatment. The optimal wrist position during casting has been discussed extensively, with dorsiflexion shown to help prevent re...

Post-obligation physician retention among Jichi Medical University graduates in Okinawa prefecture, Japan: a descriptive comparative study of the Kyushu region

Abstract Background Global strategies to address physician maldistribution include recruiting students with rural backgrounds, community-based training, bonded service, financial incentives, and personal and professional support. However, retention after obligatory service remain...

Artificial hibernation reveals synaptic engram architecture associated with memory retention

Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal representations after memory formation suggest alternative possibilities. To elucidate t...

Meta‐Analysis: Prevalence of Non‐ Helicobacter pylori , Non‐ NSAID Peptic Ulcer Disease

BACKGROUND: Non-Helicobacter pylori (H. pylori), non-nonsteroidal anti-inflammatory drug (NSAID) peptic ulcer disease (PUD) is increasingly recognized as a distinct subgroup, but its proportion across clinical presentations remains unclear. AIM: We aimed to estimate this proporti...

Urethral Metastasis of Therapy‐Induced Neuroendocrine Prostate Cancer Successfully Managed With Chemoradiotherapy: A Case Report

ABSTRACT Introduction Urethral metastasis of prostate cancer is exceptionally rare, particularly in castration‐resistant disease. Therapy‐induced neuroendocrine prostate cancer (t‐NEPC) is an aggressive variant with limited treatment options. Case Presentation A 72‐year‐old man,...

Epidemiology of Kawasaki Disease After the COVID-19 Pandemic in Japan 2023-2024

Importance: The COVID-19 pandemic may serve as a natural experiment, with pandemic-associated changes in the epidemiology of Kawasaki disease (KD) potentially informing understanding of KD pathogenesis. Objectives: To assess long-term KD incidence across 50 years and to examine p...