Jiangsu University

Firsekibart for gouty arthritis: a review of clinical efficacy, safety, and therapeutic positioning

Abstract Introduction Gout is the most prevalent inflammatory arthritis worldwide, yet conventional treatments—non-steroidal anti-inflammatory drugs, colchicine, and glucocorticoids—are limited by efficacy ceilings, safety concerns, and contraindications in patients with renal im...

A Randomized Placebo-Controlled Trial of HTD1801 Monotherapy in Participants With Type 2 Diabetes

OBJECTIVE: The safety and efficacy of HTD1801 versus placebo were evaluated in participants with type 2 diabetes inadequately controlled with diet and exercise. RESEARCH DESIGN AND METHODS: Key entry criteria of this phase 3, randomized, placebo-controlled trial included type 2 d...

How can carbon quota pledge financing contribute to the two-stage production and carbon abatement of emission-dependent remanufacturing firms?

Due to the severe environmental pollution problem and the guidance of carbon emission reduction (CER) policies by the government, firms conduct carbon abatement investment (CAI) through different CER paths to realize low carbon production, in which capital constraint may be a sig...

Research on Material Conveying and Collection Technology During Crop Harvesting

Material conveying and collection are critical to harvesting efficiency, crop quality, energy consumption, and operational continuity in combine harvesters. However, existing studies mainly focus on individual technologies, while systematic criteria for technology comparison and...

Recent Advances of Metal–Organic Frameworks‐Based Sensors for Food Safety and Environmental Monitoring

Metal‐organic frameworks (MOFs) are versatile porous materials increasingly used in sensing for food safety and environmental monitoring, where on‐site detection is critical. Compared to traditional methods, MOF‐based sensors offer higher surface areas, tunable pores, abundant ac...

In situ synthesis of microbial Ca-alginate coated nZVI for Cr(VI) remediation in soil

Nano zero-valent iron (nZVI) is highly effective in removing a wide range of pollutants, including halogenated compounds, nitrates, phosphates, polycyclic aromatic hydrocarbons, and heavy metals, establishing it as a leading nanomaterial for soil and groundwater remediation. Its...

Surface and structural characteristics of cast NiTi alloy impacted by submerged cavitating waterjet

The NiTi alloy has great application potential in the engineering fields involving cavitation. The present study aims to reveal variations in surface and structure characteristics of the NiTi alloy subjected to submerged waterjet. Effects of the standoff distance and cavitation t...

Stepwise stabilization of low-melting constituents enables grain refinement and overburning suppression in highly alloyed Al–Zn–Mg–Cu alloys

High-strength Al–Zn–Mg–Cu alloys require high-temperature solution treatment to increase solute supersaturation, but severe Zn/Mg/Cu segregation and low-melting eutectic constituents make them highly vulnerable to overburning. Here, a multi-stage solution treatment (MST: 450/2h +...

Enhanced Selective Oxidation of 5-Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid over Pt–Au/XC Bimetallic Catalysts

The catalytic valorization of biomass-derived 5-hydroxymethylfurfural (HMF) provides an important route toward sustainable chemical production. Herein, we report a bimetallic Pt1Au1 catalyst supported on Vulcan XC-72R carbon (Pt1Au1/XC) that enables efficient aerobic oxidation of...

Deciphering the landscape of human pathogenome in non-typhoidal Salmonella through multidimensional genomics

Non-typhoidal Salmonella (NTS) is a leading foodborne pathogen causing severe gastrointestinal and systemic infections, posing a significant global health burden. This study employed a genomic approach to investigate the functional and distribution characteristics of human pathog...

A Comprehensive Assessment Framework for the Sustainable Ecological Carrying Capacity of Chinese Cities Based on Time-Series Uncertainty and Interval-Valued Fermatean Fuzzy Sets

The assessment of sustainable ecological carrying capacity (SECC) serves as a crucial scientific foundation for supporting high-quality urbanization, advancing ecological civilization, and achieving the strategic goals of the “Dual Carbon” initiative. However, existing assessment...

CM-YOLO: an improved YOLOv8 for defect detection and classification of CFRP composites using infrared thermography

Driven by the pursuit of higher operating efficiency and better structural safety, carbon-fibre-reinforced polymer (CFRP) composites are widely adopted in critical aerospace structural components. Infrared thermography has emerged as a powerful non-destructive technique for subsu...

Three-DimensionalNickel Cobalt Molybdenum SelenideNetwork Construction for High-Performance Supercapacitors

Abstract Supercapacitors are valued for high power density and long cycle life, yet their low energy density remains a key challenge. Multi-metallic selenides, which are characterized by their extensive redox chemistry and high electrical conductivity, have been identified as a p...

Association of D-dimer/Lymphocyte ratio with severity in acute pancreatitis: a cross-sectional study

The D-dimer/lymphocyte ratio (DLR) reflects coagulation activation and immune status, but its association with the severity of acute pancreatitis (AP) remains unclear. This study aimed to investigate the relationship between DLR and AP severity. This cross-sectional study include...

Ferroelectric domain engineering for tunable catalysis

Ferroelectric materials, distinguished by their unique spontaneous and electrically switchable polarization, have emerged as a transformative platform for dynamically regulating various catalytic processes. The rational design and engineering of ferroelectric domain configuration...

Sex differences in neurogenic hypertension: estrogen modulation of NADPH oxidase signaling in the rostral ventrolateral medulla

Abstract Neurogenic hypertension is characterized by sustained sympathetic activation arising from dysregulation within the central autonomic network. The rostral ventrolateral medulla (RVLM) is a major sympathetic premotor region that integrates reflex, neurohumoral, inflammator...

Financial inclusion and multidimensional poverty alleviation: the moderating role of governance efficiency in Asian countries

<title>Abstract</title> Persistent multidimensional poverty across Asia reflects systemic inequalities in economic participation, where financial exclusion exacerbates deprivation in health, education, and living standards. While financial inclusion is widely advocated for povert...

Development of Machine Learning Models for Predicting the Fertilizer Suction Characteristics of an Asymmetric Venturi Injector

The fertilizer suction performance of Venturi injectors is jointly governed by fertilizer-solution properties and hydraulic boundary conditions, resulting in multivariable and potentially nonlinear responses that may be difficult to characterize using simplified empirical relatio...

Strategies for the Integration of Multifunctional Thermal Management Materials: A Review

Abstract The rapid development of high-power electronics, flexible devices, and advanced energy systems has created a growing demand for thermal management materials that combine heat dissipation with additional functions such as electrical insulation, electromagnetic interferenc...

A hybrid time-weighted dynamic time warping and TKNN classifier for paddy rice mapping using time-series Sentinel-1 SAR data

Accurate rice extraction is essential for agricultural monitoring. However, traditional methods using Euclidean Distance (ED) or Dynamic Time Warping (DTW) are limited by noise sensitivity and ignoring temporal order. This paper proposes a new method combining Time-Weighted Dynam...